Michael T. Brennan
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View article: (410) Infection Rates in Penile Prosthesis Surgery Utilizing 0.05% Chlorhexidine Gluconate vs Individualize Antibiotic Dips
(410) Infection Rates in Penile Prosthesis Surgery Utilizing 0.05% Chlorhexidine Gluconate vs Individualize Antibiotic Dips Open
Introduction The most dreaded complication of penile prosthesis surgery is infection, the rates of which have declined to 1-3% for high volume implanters. Historically each implanter utilized their own individualized combination of antibio…
View article: Safety and Efficacy of LP-10 Liposomal Tacrolimus in Oral Lichen Planus: A Multicenter Phase 2 Trial
Safety and Efficacy of LP-10 Liposomal Tacrolimus in Oral Lichen Planus: A Multicenter Phase 2 Trial Open
NCT06233591.
View article: SAT-741 Rapid Resolution Of Transient Hypoparathyroidism Following Total Laryngectomy With Thyroidectomy: A Case Series And Review
SAT-741 Rapid Resolution Of Transient Hypoparathyroidism Following Total Laryngectomy With Thyroidectomy: A Case Series And Review Open
Disclosure: A. Denha: None. M. Kashat: None. M. Brennan: None. Introduction: Extracellular calcium levels are tightly regulated by parathyroid hormone (PTH), vitamin D, and calcitonin, acting on bone, kidneys, and the GI tract. Hypoparathy…
View article: Patient‐Reported Oral Symptoms and Their Impact on Well‐Being After Haematopoietic Cell Transplantation
Patient‐Reported Oral Symptoms and Their Impact on Well‐Being After Haematopoietic Cell Transplantation Open
Objective Oral complications may negatively influence outcomes of haematopoietic cell transplantation (HCT). A comprehensive view of oral symptoms and symptom burden post‐HCT is lacking. This study aimed to determine the prevalence, severi…
View article: Salivary Proteome Profile of Xerostomic Patients Reveals Pathway Dysregulation Related to Neurodegenerative Diseases: A Pilot Study
Salivary Proteome Profile of Xerostomic Patients Reveals Pathway Dysregulation Related to Neurodegenerative Diseases: A Pilot Study Open
Xerostomia, the subjective complaint of a dry mouth, is frequently associated with salivary flow reduction and/or salivary gland hypofunction. This condition significantly impacts an individual’s quality of life and oral health, including …
View article: The impact of medications on salivary flow and oral health-related quality of life in postradiation head and neck cancer patients: results of the OraRad study
The impact of medications on salivary flow and oral health-related quality of life in postradiation head and neck cancer patients: results of the OraRad study Open
Antidepressants were associated with reduced stimulated salivary flow, but no cumulative negative effect on whole stimulated salivary flow was identified. Polypharmacy was associated with worse OH-QOL.
View article: Transcriptomic Profile of Oral Cancer Lesions: A Proof-of-Concept Pilot Study of FFPE Tissue Sections
Transcriptomic Profile of Oral Cancer Lesions: A Proof-of-Concept Pilot Study of FFPE Tissue Sections Open
Oral squamous cell carcinoma (OSCC) is a malignancy that affects the oral mucosa and is characterized by indurated oral lesions. The RNAseq of formalin-fixed, paraffin-embedded (FFPE) samples is readily available in clinical settings. Such…
View article: The effect of conditioning regimen intensity on periodontal health in haematopoietic cell transplantation recipients: a 5-year multicentre prospective cohort study
The effect of conditioning regimen intensity on periodontal health in haematopoietic cell transplantation recipients: a 5-year multicentre prospective cohort study Open
Objectives To evaluate periodontal health and its association with conditioning intensity over five years post-HCT. Materials and methods This multicentre prospective study included 104 patients from two Dutch centres. Probing pocket depth…
View article: Planned Dental Extractions After Radiation Therapy
Planned Dental Extractions After Radiation Therapy Open
Importance Nonrestorable teeth are recommended to be extracted prior to radiation therapy (RT). Occasionally, preradiation extractions introduce unacceptable delays in treatment initiation. Planned dental extractions immediately postradiat…
View article: Females have lower salivary flow than males, before and after radiation therapy for head/neck cancer
Females have lower salivary flow than males, before and after radiation therapy for head/neck cancer Open
Objective To compare salivary flow rates between females and males, before and after radiation therapy (RT) for head and neck cancer (HNC). Methods Prospective observational multicenter cohort study (OraRad). Stimulated whole salivary flow…
View article: Regulation of STAT1 and STAT4 Expression by Growth Factor and Interferon Supplementation in Sjögren’s Syndrome Cell Culture Models
Regulation of STAT1 and STAT4 Expression by Growth Factor and Interferon Supplementation in Sjögren’s Syndrome Cell Culture Models Open
Our goal was to investigate the effects of epidermal growth factor (EGF) and interferons (IFNs) on signal transducer and activator of transcription STAT1 and STAT4 mRNA and active phosphorylated protein expression in Sjögren’s syndrome cel…
View article: Variants in the<i>DDX6-CXCR5</i>autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland
Variants in the<i>DDX6-CXCR5</i>autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland Open
Fine mapping and bioinformatic analysis of the DDX6-CXCR5 genetic risk association in Sjögren’s Disease (SjD) and Systemic Lupus Erythematosus (SLE) identified five common SNPs with functional evidence in immune cell types: rs4938573, rs57…
View article: Identification of single nucleotide polymorphisms (SNPs) associated with chronic graft-versus-host disease in patients undergoing allogeneic hematopoietic cell transplantation
Identification of single nucleotide polymorphisms (SNPs) associated with chronic graft-versus-host disease in patients undergoing allogeneic hematopoietic cell transplantation Open
Introduction Chronic graft-versus-host disease (cGVHD) is a debilitating side effect of allogeneic hematopoietic cell transplantation (HCT), affecting the quality of life of patients. We used whole exome sequencing to identify candidate SN…
View article: Human oral mucosa and oral microbiome interactions following supragingival plaque reconstitution in healthy volunteers: a diet-controlled balanced design proof-of-concept model to investigate oral pathologies
Human oral mucosa and oral microbiome interactions following supragingival plaque reconstitution in healthy volunteers: a diet-controlled balanced design proof-of-concept model to investigate oral pathologies Open
Changes in the oral microbiome may contribute to oral pathologies, especially in patients undergoing cancer therapy. Interactions between oral microbiome and oral mucosa may exacerbate inflammation. We determined whether probiotic-controll…
View article: Oral health in patients scheduled for hematopoietic stem cell transplantation in the Orastem study
Oral health in patients scheduled for hematopoietic stem cell transplantation in the Orastem study Open
Despite advances in transplant medicine, prevalence of complications after hematopoietic stem cell transplantation (HSCT) remains high. The impact of pre-HSCT oral health factors on the incidence and severity of complications post-HSCT is …
View article: World Workshop on Oral Medicine VIII: Development of a core outcome set for oral lichen planus: a consensus study
World Workshop on Oral Medicine VIII: Development of a core outcome set for oral lichen planus: a consensus study Open
The COS developed by consensus will help reduce the heterogeneity of outcomes measured in interventional trials. This will allow future pooling of outcomes and data for meta-analyses. This project showed the effectiveness of a methodology …