Explanipedia

Clearance of Hepatitis C Viremia During Direct‐Acting Antiviral Therapy Leads to Rapid Changes in Lipid and Lipoprotein Metabolism Open

Zahra Sarrafan‐Chaharsoughi, Varun Takyar, Sungyoung Auh, Gérald Née, Ahmad S. Alawad , et al. · 2025

Background and Aims Chronic hepatitis C virus (HCV) infection is associated with hypolipidemia. HCV eradication may, therefore, result in hyperlipidemia and increase cardiovascular disease (CVD) risk. We investigated the impact of HCV erad…

5123 Remission of Antibodies Blocking the Insulin Receptor Reduces Atherogenicity of LDL Particles but Increases HDL Particle Atherogenicity Open

Mark C. Hwang, Robert D. Shamburek, Marissa Lightbourne, Maureen Sampson, Alan T. Remaley , et al. · 2024

Disclosure: M. Hwang: None. R. Shamburek: None. M. Lightbourne: None. M. Sampson: None. A. Remaley: None. B. Abel: None. R.J. Brown: None. Background: Type B insulin resistance syndrome (TBIR) is a rare autoimmune disorder defined by the p…

FRI056 Effect Of 48 Hour Of Metreleptin In Humans With Lipodystrophy During Controlled Feeding Open

Khulood Bukhari, Brent S. Abel, Rebecca J. Brown · 2023

Disclosure: K.M. Bukhari: None. B. Abel: None. R.J. Brown: None. Introduction: The lipodystrophy (LD) syndromes are a rare group of disorders characterized by a generalized or partial loss of adipose tissue resulting in a deficiency of the…

THU350 Rapid Decrease Of Glycemic Levels In Three Patients With Severe Insulin Resistance Associated With Bell’s Palsy. Open

Elías Chuki, Marissa Lightbourne, Brent S. Abel, Rebecca J. Brown · 2023

Disclosure: E. Chuki: None. M. Lightbourne: None. B. Abel: None. R.J. Brown: None. Bell’s palsy (BP) is associated with diabetic angiopathy and facial nerve ischemia and may be the first sign of diabetic mononeuropathy. Specific risk facto…

THU267 A Novel In Vitro Assay Correlates Insulin Receptor Autoantibodies To Fasting Insulin In Type B Insulin Resistance Open

Brent S. Abel, Waldemar B. Minich, Christian Schwiebert, Tim Welsink, Petra Seemann , et al. · 2023

Disclosure: B. Abel: None. W. Minich: Stock Owner; Self; ImmunometriX GmbH. C. Schwiebert: Employee; Self; Bruker Corporation. T. Welsink: Employee; Self; Bruker Corporation. P. Seemann: Stock Owner; Self; ImmunometriX GmbH, selenOmed GmbH…

THU268 Hyperuricemia In Insulin Resistance Is Associated With Increased Synthesis And Not Decreased Renal Excretion Of Uric Acid In Humans Open

Romanos Haykal, Alexandra Kinzer, Brent S. Abel, Marissa Lightbourne, Megan Startzell , et al. · 2023

Disclosure: R. Haykal: None. A. Kinzer: None. B. Abel: None. M. Lightbourne: None. M.S. Startzell: None. E. Cochran: None. R.J. Brown: None. Title: Hyperuricemia in insulin resistance is associated with increased synthesis and not decrease…

Insulin Signaling Through the Insulin Receptor Increases Linear Growth Through Effects on Bone and the GH–IGF-1 Axis Open

Marinna Okawa, Rebecca Tuska, Marissa Lightbourne, Brent S. Abel, Mary Walter , et al. · 2023

Context Childhood overnutrition is associated with increased growth and bone mineral density (BMD) vs the opposite for undernutrition. The role of insulin receptor (InsR) signaling in these phenotypes is unclear. Rare disease patients with…

CDK4-E2F3 signals enhance oxidative skeletal muscle fiber numbers and function to affect myogenesis and metabolism Open

Young Jae Bahn, Hariom Yadav, Paolo Piaggi, Brent S. Abel, Oksana Gavrilova , et al. · 2023

Understanding how skeletal muscle fiber proportions are regulated is vital to understanding muscle function. Oxidative and glycolytic skeletal muscle fibers differ in their contractile ability, mitochondrial activity, and metabolic propert…

A Novel In Vitro Assay Correlates Insulin Receptor Autoantibodies With Fasting Insulin in Type B Insulin Resistance Open

Waldemar B. Minich, Brent S. Abel, Christian Schwiebert, Tim Welsink, Petra Seemann , et al. · 2023

Context Severe insulin resistance (IR) in the presence of insulin receptor autoantibodies (InsR-aAb) is known as type B insulin resistance (TBIR). Considerable progress in therapy has been achieved, but diagnosis and monitoring of InsR-aAb…

RF10 | PMON221 11-Oxygenated-Androgens in Females with Severe Insulin Resistance Open

Deborah P. Merke, Dalia Walzer, Adina F. Turcu, Smita Jha, Brent S. Abel , et al. · 2022

Background Female patients with severe insulin resistance (SIR) often have high testosterone (T) and a polycystic ovary syndrome (PCOS)-like phenotype. Causes of SIR include disorders of the insulin receptor (INSR), in which all insulin re…

Characterization and clinical association of autoantibodies against Perilipin 1 in patients with acquired generalized lipodystrophy Open

Fernando Corvillo, Brent S. Abel, Alberto López‐Lera, Giovanni Ceccarini, Silvia Magno , et al. · 2022

Acquired generalized lipodystrophy (AGL) is a rare condition characterized by massive loss of adipose tissue through the body, causing severe metabolic complications. Autoimmune destruction of adipocytes is strongly suspected based on th…

Characterization and Clinical Association of Autoantibodies Against Perilipin 1 in Patients With Acquired Generalized Lipodystrophy Open

Fernando Corvillo, Brent S. Abel, Alberto López‐Lera, Giovanni Ceccarini, Silvia Magno , et al. · 2022

Acquired generalized lipodystrophy (AGL) is a rare condition characterized by massive loss of adipose tissue through the body, causing severe metabolic complications. Autoimmune destruction of adipocytes is strongly suspected based on the …

Characterization and clinical association of autoantibodies against Perilipin 1 in patients with acquired generalized lipodystrophy Open

Fernando Corvillo, Brent S. Abel, Alberto López‐Lera, Giovanni Ceccarini, Silvia Magno , et al. · 2022

Acquired generalized lipodystrophy (AGL) is a rare condition characterized by massive loss of adipose tissue through the body, causing severe metabolic complications. Autoimmune destruction of adipocytes is strongly suspected based on th…

Excess 11-Oxygenated Androgens in Women With Severe Insulin Resistance Are Mediated by Adrenal Insulin Receptor Signaling Open

Dalia Walzer, Adina F. Turcu, Smita Jha, Brent S. Abel, Richard J. Auchus , et al. · 2022

Context Syndromes of severe insulin resistance (SIR) include insulin receptoropathy, in which all signaling downstream of the insulin receptor is lost, and lipodystrophy, in which some signaling pathways are impaired and others preserved. …

Patient and Provider Perspectives on Postsurgical Recovery of Cushing Syndrome Open

Rachel Acree, Caitlin M Miller, Brent S. Abel, Nicola M. Neary, Karen K. Campbell , et al. · 2021

Context Cushing syndrome (CS) is associated with impaired health-related quality of life (HRQOL) even after surgical cure. Objective To characterize patient and provider perspectives on recovery from CS, drivers of decreased HRQOL during r…

Enhanced Insulin Signaling Through Its Receptor Is Needed for the Development of Hyperuricemia in Humans Open

Romanos Haykal, Alexandra Kinzer, Brent S. Abel, Megan Startzell, Elaine Cochran , et al. · 2021

Background: There is an association between insulin resistance (IR) and hyperuricemia but the direction of causalityand mechanisms are unclear. In obesity and lipodystrophy, IR is “selective”, with lack of insulin signalingcausing hypergly…

Racial Disparities Among Clinical Trials for Inherited Forms of Lipodystrophy Open

Brent S. Abel, Elaine Cochran, Megan Startzell, Rebecca J. Brown · 2021

Background: There has been renewed interest in understanding how medical research serves minority communities disproportionally affected by disease. A recent study in a predominantly white population identified 12 subjects with partial lip…

Apolipoprotein CIII and Angiopoietin-like Protein 8 are Elevated in Lipodystrophy and Decrease after Metreleptin Open

Marissa Lightbourne, Anna Wolska, Brent S. Abel, Kristina I. Rother, Mary Walter , et al. · 2020

Context Lipodystrophy syndromes cause hypertriglyceridemia that improves with leptin treatment using metreleptin. Mechanisms causing hypertriglyceridemia and improvements after metreleptin are incompletely understood. Objective Determine r…

Prevalence of Hypothyroidism in Patients With Erdheim-Chester Disease Open

Skand Shekhar, Ninet Sinaii, Jorge A. Irizarry‐Caro, William A. Gahl, Juvianee Estrada‐Veras , et al. · 2020

In this cohort study, a higher prevalence of central and primary hypothyroidism was identified in patients with ECD compared with the community. There should be a low threshold for testing for hypothyroidism in patients with ECD, and treat…

SUN-LB4 Androgenic Profiles of Patients With Severe Insulin Resistance Open

Smita Jha, Adina F. Turcu, Brittany Brookner, Brent S. Abel, Megan Startzell , et al. · 2020

Background Patients with severe insulin resistance have ovarian hyperthecosis, high testosterone (T) and minimal adipose tissue. Recent studies have found elevated levels of 11-oxygenated (11-oxy) androgens in women with polycystic ovary s…

Reduced Insulin Clearance and Insulin-Degrading Enzyme Activity Contribute to Hyperinsulinemia in African Americans Open

Andin Fosam, Shanaz Sikder, Brent S. Abel, Sri Harsha Tella, Mary Walter , et al. · 2020

Background African Americans (AAs) are at a higher risk for developing type 2 diabetes compared with non-Hispanic whites (NHWs). The causal role of β-cell glucose sensitivity (β-GS) and insulin clearance in hyperinsulinemia in AA adults is…

Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis Open

Sai P. Pydi, Shanu Jain, Wesley Tung, Yinghong Cui, Lu Zhu , et al. · 2019

Assessing the predictive accuracy of oral glucose effectiveness index using a calibration model Open

Michael Glicksman, Shivraj Grewal, Shrayus Sortur, Brent S. Abel, Sungyoung Auh , et al. · 2018

Predictive Accuracy of Surrogate Indices for Hepatic and Skeletal Muscle Insulin Sensitivity Open

Ranganath Muniyappa, Sri Harsha Tella, Shrayus Sortur, Reed Mszar, Shivraj Grewal , et al. · 2018

Our findings indicate that the surrogate indices derived from an OGTT are accurate in predicting insulin sensitivity but are not tissue specific.

Effects of growth hormone administration on luteinizing hormone secretion in healthy older men and women Open

Ranganath Muniyappa, Shannon D. Sullivan, Sri Harsha Tella, Brent S. Abel, S. Mitchell Harman , et al. · 2017

The known interactions between the somatotropic and hypothalamic-pituitary-gonadal (HPG) axes have not been well delineated in older individuals. Aging-associated decline in insulin like growth factor-1 (IGF-1) levels has been proposed to …

Plasma serpinB1 is related to insulin sensitivity but not pancreatic <i>β</i>‐Cell function in non‐diabetic adults Open

Michael Glicksman, Asha Asthana, Brent S. Abel, Mary Walter, Monica C. Skarulis , et al. · 2017

Pancreatic β ‐cell dysfunction because of reduced β ‐cell mass and function is a primary determinant in the progression of diabetes. Increase in β ‐cell mass and compensatory hyperinsulinaemia is frequently associated with insulin‐resistan…

Metreleptin therapy lowers plasma angiopoietin-like protein 3 in patients with generalized lipodystrophy Open

Ranganath Muniyappa, Brent S. Abel, Asha Asthana, Mary Walter, Elaine Cochran , et al. · 2017

TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis Open

Christine C. Krieger, Robert F. Place, Carmine Bevilacqua, Bernice Marcus‐Samuels, Brent S. Abel , et al. · 2016

Context: The TSH receptor (TSHR) is considered the main target of stimulatory autoantibodies in the pathogenesis of Graves' ophthalmopathy (GO); however, it has been suggested that stimulatory IGF-1 receptor (IGF-1R) autoantibodies also pl…

Effect of Leptin Administration on Circulating Apolipoprotein CIII levels in Patients With Lipodystrophy Open

Andrea Kassai, Ranganath Muniyappa, Amy E. Levenson, Mary Walter, Brent S. Abel , et al. · 2016

Leptin replacement in lipodystrophy did not alter serum apoCIII levels. Elevated apoCIII may play a role in the hypertriglyceridemia of lipodystrophy independent of leptin deficiency and replacement.

An improved micro-method for the measurement of steroid profiles by APPI-LC–MS/MS and its use in assessing diurnal effects on steroid concentrations and optimizing the diagnosis and treatment of adrenal insufficiency and CAH Open

Brian Stolze, Verena Gounden, Jianghong Gu, Elizabeth Elliott, L Masika , et al. · 2015

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