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View article: Pair‐Feeding Study Designs Can Create Biases and Inflate Type I Error Rates: A Simulation Study
Pair‐Feeding Study Designs Can Create Biases and Inflate Type I Error Rates: A Simulation Study Open
Objective Pair‐feeding is a study design element where one group's food intake is provided to another group to assess whether a treatment effect is independent of food intake. Investigators often assume equivalent food intake across experi…
View article: Inulin Increases Lean Mass and Improves HOMA-IR in Mice Fed Standard AIN93 Diet but Not in High Fat Diets
Inulin Increases Lean Mass and Improves HOMA-IR in Mice Fed Standard AIN93 Diet but Not in High Fat Diets Open
View article: Dietary Intake of Chromista Oil Alters Hepatic Metabolomic Profile of Mice With Excess Fat Mass
Dietary Intake of Chromista Oil Alters Hepatic Metabolomic Profile of Mice With Excess Fat Mass Open
Increasing dietary intake of fish oil is frequently recommended for decreasing the risk for cardiovascular diseases and improving metabolic health. We hypothesised that dietary intake of chromista oil (a marine food product and a rich sour…
View article: Initial implicit association between whole grains and taste does not predict consumption of whole grains in low-whole grain consumers: a pilot randomized controlled trial
Initial implicit association between whole grains and taste does not predict consumption of whole grains in low-whole grain consumers: a pilot randomized controlled trial Open
Background Health benefits of whole grain (WG) consumption are well documented. Current Dietary Guidelines for Americans recommend at least half of total grains consumed be WG; however, Americans consume less than one serving of WG per day…
View article: Time-restricted feeding restores metabolic flexibility in adult mice with excess adiposity
Time-restricted feeding restores metabolic flexibility in adult mice with excess adiposity Open
Introduction Obesity is prevalent with the adult population in the United States. Energy-dense diets and erratic eating behavior contribute to obesity. Time-restricted eating is a dietary strategy in humans that has been advanced to reduce…
View article: Metabolomic Alteration in Adipose Monocyte Chemotactic Protein-1 Deficient Mice Fed a High-Fat Diet
Metabolomic Alteration in Adipose Monocyte Chemotactic Protein-1 Deficient Mice Fed a High-Fat Diet Open
Monocyte chemotactic protein-1 (MCP-1), a small inducible cytokine, is involved in obesity-related chronic disorders. Adipocytes produce MCP-1 that is elevated in obese humans and in rodent models of obesity. This study examined the hepati…
View article: P03-075-23 One-Week Elderberry Juice Treatment Increases Carbohydrate Oxidation After a Meal Tolerance Test and Is Well Tolerated in Adults: A Controlled Pilot Study
P03-075-23 One-Week Elderberry Juice Treatment Increases Carbohydrate Oxidation After a Meal Tolerance Test and Is Well Tolerated in Adults: A Controlled Pilot Study Open
View article: One-Week Elderberry Juice Treatment Increases Carbohydrate Oxidation after a Meal Tolerance Test and Is Well Tolerated in Adults: A Randomized Controlled Pilot Study
One-Week Elderberry Juice Treatment Increases Carbohydrate Oxidation after a Meal Tolerance Test and Is Well Tolerated in Adults: A Randomized Controlled Pilot Study Open
Obesity in the United States continues to worsen. Anthocyanin-rich fruits and vegetables provide a pragmatic dietary approach to slow its metabolic complications. Given American diet patterns, foods with high anthocyanin content could addr…
View article: Time-Restricted Feeding Modifies the Fecal Lipidome and the Gut Microbiota
Time-Restricted Feeding Modifies the Fecal Lipidome and the Gut Microbiota Open
Time-restricted feeding (TRF) has been identified as an approach to reduce the risk of obesity-related metabolic diseases. We hypothesize that TRF triggers a change in nutrient (e.g., dietary fat) absorption due to shortened feeding times,…
View article: One-Week Elderberry Juice Treatment Increases Carbohydrate Oxidation After a Meal Tolerance Test and is Well Tolerated in Adults: A Randomized Controlled Pilot Study
One-Week Elderberry Juice Treatment Increases Carbohydrate Oxidation After a Meal Tolerance Test and is Well Tolerated in Adults: A Randomized Controlled Pilot Study Open
Obesity in the United States continues to worsen. Anthocyanin-rich fruits and vegetables provide a pragmatic dietary approach to slow its metabolic complications. Given American diet patterns, foods with high anthocyanin content could addr…
View article: Consumption of a high-fat diet alters transcriptional rhythmicity in liver from pubertal mice
Consumption of a high-fat diet alters transcriptional rhythmicity in liver from pubertal mice Open
Introduction Childhood obesity is associated with adult obesity, which is a risk factor for chronic diseases. Obesity, as an environmental cue, alters circadian rhythms. The hypothesis of this study was that consumption of a high-fat diet …
View article: Metabolomic Alterations in Mammary Glands from Pubertal Mice Fed a High-Fat Diet
Metabolomic Alterations in Mammary Glands from Pubertal Mice Fed a High-Fat Diet Open
Dietary malpractice is a risk factor for obesity. This study tested the hypothesis that consumption of a high-fat diet alters mammary metabolome in pubertal mice. We performed untargeted metabolomic analysis of primary metabolism on mammar…
View article: Metabolomes of Lewis lung carcinoma metastases and normal lung tissue from mice fed different diets
Metabolomes of Lewis lung carcinoma metastases and normal lung tissue from mice fed different diets Open
Metastasis is a devastating aspect of cancer. This study tested the hypothesis that metabolome of metastases differs from that of host organs by using the spontaneous metastasis model of Lewis lung carcinoma (LLC). In a 2 × 2 design, male …
View article: Alteration in Plasma Metabolome in High-Fat Diet-Fed Monocyte Chemotactic Protein-1 Knockout Mice Bearing Pulmonary Metastases of Lewis Lung Carcinoma
Alteration in Plasma Metabolome in High-Fat Diet-Fed Monocyte Chemotactic Protein-1 Knockout Mice Bearing Pulmonary Metastases of Lewis Lung Carcinoma Open
Both clinical and laboratory studies have shown that monocyte chemotactic protein-1 (MCP-1) is involved in cancer spread. To understand the role of MCP-1 in metabolism in the presence of metastasis, we conducted an untargeted metabolomic a…
View article: Resistant starch wheat increases PYY and decreases GIP but has no effect on self-reported perceptions of satiety
Resistant starch wheat increases PYY and decreases GIP but has no effect on self-reported perceptions of satiety Open
Dietary fiber has numerous health benefits, such as increasing satiety, and is regularly included in healthy dietary recommendations. However, different types and sources of fiber vary in their chemical properties and biological effects. T…
View article: Mammary Tumorigenesis and Metabolome in Male Adipose Specific Monocyte Chemotactic Protein-1 Deficient MMTV-PyMT Mice Fed a High-Fat Diet
Mammary Tumorigenesis and Metabolome in Male Adipose Specific Monocyte Chemotactic Protein-1 Deficient MMTV-PyMT Mice Fed a High-Fat Diet Open
Male breast cancer, while uncommon, is a highly malignant disease. Monocyte chemotactic protein-1 (MCP-1) is an adipokine; its concentration in adipose tissue is elevated in obesity. This study tested the hypothesis that adipose-derived MC…
View article: Dietary Fat Chain Length, Saturation, and PUFA Source Acutely Affect Diet-Induced Thermogenesis but Not Satiety in Adults in a Randomized, Crossover Trial
Dietary Fat Chain Length, Saturation, and PUFA Source Acutely Affect Diet-Induced Thermogenesis but Not Satiety in Adults in a Randomized, Crossover Trial Open
Structural differences in dietary fatty acids modify their rate of oxidation and effect on satiety, endpoints that may influence the development of obesity. This study tests the hypothesis that meals containing fat sources with elevated un…
View article: Intake of a Mediterranean Diet Reduces Atherogenic Lipid Profiles but the Effect Is Diminished by Daily Egg Intake
Intake of a Mediterranean Diet Reduces Atherogenic Lipid Profiles but the Effect Is Diminished by Daily Egg Intake Open
View article: Identification of Phenotypic Lipidomic Signatures in Response to Long Chain n‐3 Polyunsaturated Fatty Acid Supplementation in Humans
Identification of Phenotypic Lipidomic Signatures in Response to Long Chain n‐3 Polyunsaturated Fatty Acid Supplementation in Humans Open
Background Supplementation with long chain n‐3 polyunsaturated fatty acids is used to reduce total circulating triacylglycerol (TAG) concentrations. However, in about 30% of people, supplementation with long chain n‐3 polyunsaturated fatty…
View article: Metabolome of Mammary Tumors Differs from Normal Mammary Glands But Is Not Altered by Time-restricted Feeding Under Obesogenic Conditions
Metabolome of Mammary Tumors Differs from Normal Mammary Glands But Is Not Altered by Time-restricted Feeding Under Obesogenic Conditions Open
The null effect of TRF on the metabolomic profile does not rule out changes in more refined intracellular signaling pathways. It suggests that the protection of TRF against mammary tumorigenesis may rely upon its action on the host rather …
View article: Inulin Improves Insulin Sensitivity, Changes Cecal Bile Acids, but Does Not Mitigate Hepatic Steatosis from an Obesogenic, High Fat Diet
Inulin Improves Insulin Sensitivity, Changes Cecal Bile Acids, but Does Not Mitigate Hepatic Steatosis from an Obesogenic, High Fat Diet Open
View article: Plasma Metabolomic Changes in Mice With Time-restricted Feeding-attenuated Spontaneous Metastasis of Lewis Lung Carcinoma
Plasma Metabolomic Changes in Mice With Time-restricted Feeding-attenuated Spontaneous Metastasis of Lewis Lung Carcinoma Open
Time-restricted feeding improves metabolic profile of LLC-bearing mice.
View article: Liking and Acceptability of Whole Grains Increases with a 6-Week Exposure but Preferences for Foods Varying in Taste and Fat Content Are Not Altered: A Randomized Controlled Trial
Liking and Acceptability of Whole Grains Increases with a 6-Week Exposure but Preferences for Foods Varying in Taste and Fat Content Are Not Altered: A Randomized Controlled Trial Open
Mere exposure to WG foods represents a feasible and easily applied behavioral strategy for increasing consumption of WGs. Encouraging consumers to focus on enjoyment of the taste may be more effective than emphasizing the health benefits o…
View article: Time-Restricted Feeding a High-fat Diet in Mice Elevates Plasma Concentration of Saturated Fatty Acids but Reduces Concentrations of Multiple Amino Acids (OR27-02-19)
Time-Restricted Feeding a High-fat Diet in Mice Elevates Plasma Concentration of Saturated Fatty Acids but Reduces Concentrations of Multiple Amino Acids (OR27-02-19) Open
OBJECTIVES: Obesity and obesity-related disease contribute to health care costs and pose serious health risks. Rodent studies indicate that time-restricted feeding (TRF) may be effective in reducing adiposity and metabolic disease associat…
View article: Saturated Fatty Acids from Dairy Increase Energy Expenditure Following an Acute Meal Challenge (P08-015-19)
Saturated Fatty Acids from Dairy Increase Energy Expenditure Following an Acute Meal Challenge (P08-015-19) Open
OBJECTIVES: Evidence suggests that the amount of fatty acid saturation and chain length affect fatty acid oxidation. Metabolism of unsaturated fatty acids may increase energy expenditure and shorter chain fatty acids may be selectively oxi…
View article: Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer
Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer Open
Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial metabolites in the colon, cause opposing effects on colonic inflammation at chronically high physiological levels. Primary BAs play critical roles…
View article: Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability, and microbial dysbiosis in high fat-fed mice
Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability, and microbial dysbiosis in high fat-fed mice Open
Microbial dysbiosis and increased intestinal permeability are targets for prevention or reversal of weight gain in high-fat (HF) diet-induced obesity (DIO). Prebiotic milk oligosaccharides (MO) have been shown to benefit the host intestine…
View article: The Effects of Moderate Whole Grain Consumption on Fasting Glucose and Lipids, Gastrointestinal Symptoms, and Microbiota
The Effects of Moderate Whole Grain Consumption on Fasting Glucose and Lipids, Gastrointestinal Symptoms, and Microbiota Open
This study was designed to determine if providing wheat, corn, and rice as whole (WG) or refined grains (RG) under free-living conditions will change parameters of health over a six-week intervention in healthy, habitual non-WG consumers. …
View article: Mutations in Durum Wheat <i>SBEII</i> Genes affect Grain Yield Components, Quality, and Fermentation Responses in Rats
Mutations in Durum Wheat <i>SBEII</i> Genes affect Grain Yield Components, Quality, and Fermentation Responses in Rats Open
Increased amylose in wheat ( Triticum ssp.) starch is associated with increased resistant starch, a fermentable dietary fiber. Fermentation of resistant starch in the large intestine produces short‐chain fatty acids that are associated wit…