Brett Colbert
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View article: Bridging Care and Cost: Evaluating the Clinical and Financial Benefits of Remote Monitoring and Chronic Care Strategies (Preprint)
Bridging Care and Cost: Evaluating the Clinical and Financial Benefits of Remote Monitoring and Chronic Care Strategies (Preprint) Open
UNSTRUCTURED Chronic disease poses a significant global health challenge, with remote patient monitoring (RPM) offering a promising solution for chronic care management (CCM). By leveraging wearable devices and sensor-based systems to con…
View article: Prevalence of Molecular Diagnoses for Usher Syndrome and the Need for Coordinated Care
Prevalence of Molecular Diagnoses for Usher Syndrome and the Need for Coordinated Care Open
Introduction Usher syndrome (USH) is a rare, autosomal‐recessive genetic disorder and a leading cause of early onset deaf‐blindness. A clinical diagnosis is made by the presence of retinitis pigmentosa (RP) with sensorineural hearing loss …
View article: Post-stroke hippocampal neurogenesis is impaired by microvascular dysfunction and PI3K signaling in cerebral amyloid angiopathy
Post-stroke hippocampal neurogenesis is impaired by microvascular dysfunction and PI3K signaling in cerebral amyloid angiopathy Open
Ischemic stroke and cerebral amyloid angiopathy (CAA) pose significant challenges in an aging population, particularly in post-stroke recovery. Using the 5xFAD mouse model, we explore the relationship between CAA, ischemic stroke, and tiss…
View article: Remote Patient Monitoring Is Associated with Improved Outcomes in Hypertension: A Large, Retrospective, Cohort Analysis
Remote Patient Monitoring Is Associated with Improved Outcomes in Hypertension: A Large, Retrospective, Cohort Analysis Open
Hypertension (HTN) is a chronic condition that requires careful monitoring and management. Blood pressure readings in the clinic and self-reported blood pressure readings are often too intermittent to allow for careful management. Remote p…
View article: Beyond the M.D.: Transdisciplinary Approaches of High-Volume Dual Degree M.D./Masters Programs at U.S. Medical Schools
Beyond the M.D.: Transdisciplinary Approaches of High-Volume Dual Degree M.D./Masters Programs at U.S. Medical Schools Open
Purpose: Transdisciplinarity been described as a fusing of theories, methods, and expertise across disciplinary boundaries to address complex, global problems. This approach has coincided with an increase in US medical schools offering Mas…
View article: Brain endothelium-derived extracellular vesicles containing amyloid-beta induce mitochondrial alterations in neural progenitor cells
Brain endothelium-derived extracellular vesicles containing amyloid-beta induce mitochondrial alterations in neural progenitor cells Open
Aim: Elevated brain deposits of amyloid beta (Aβ40) contribute to neuropathology and cognitive dysfunction in Alzheimer’s disease (AD). However, the role of the blood-brain barrier (BBB) as an interface for the transfer of Aβ40 from the pe…
View article: Precision Medicine Shows Promise to Advance the Care of Individuals with Hearing Loss
Precision Medicine Shows Promise to Advance the Care of Individuals with Hearing Loss Open
Hearing loss (HL) is the most common sensory disorder worldwide and arises from a heterogeneous set of genetic and environmental etiologies. Currently, therapy for sensorineural HL is non-specific and limited to amplification devices and i…
View article: Generation of hiPSC line UMi030-A from an individual with the hearing loss-related GJB2 mutation c.109G > A
Generation of hiPSC line UMi030-A from an individual with the hearing loss-related GJB2 mutation c.109G > A Open
Genetic variants in the GJB2 gene which encodes for the Connexin 26 protein account for ∼ 60% of cases of genetic hearing loss. A novel hiPSC line was generated from an individual with the hearing loss-related variant c.109G > A in GJB2 le…
View article: Peripheral vestibular system: Age-related vestibular loss and associated deficits
Peripheral vestibular system: Age-related vestibular loss and associated deficits Open
Given the interdependence of multiple factors in age-related vestibular loss (e.g., balance, vision, cognition), it is important to examine the individual contributions of these factors with ARVL. While the relationship between the vestibu…
View article: Effect of metronidazole on vaginal microbiota associated with asymptomatic bacterial vaginosis
Effect of metronidazole on vaginal microbiota associated with asymptomatic bacterial vaginosis Open
Vaginal dysbiosis-induced by an overgrowth of anaerobic bacteria is referred to as bacterial vaginosis (BV). The dysbiosis is associated with an increased risk for acquisition of sexually transmitted infections. Women with symptomatic BV a…
View article: Usher Syndrome in the Inner Ear: Etiologies and Advances in Gene Therapy
Usher Syndrome in the Inner Ear: Etiologies and Advances in Gene Therapy Open
Hearing loss is the most common sensory disorder with ~466 million people worldwide affected, representing about 5% of the population. A substantial portion of hearing loss is genetic. Hearing loss can either be non-syndromic, if hearing l…
View article: Stem Cells and Gene Therapy in Progressive Hearing Loss: the State of the Art
Stem Cells and Gene Therapy in Progressive Hearing Loss: the State of the Art Open
Progressive non-syndromic sensorineural hearing loss (PNSHL) is the most common cause of sensory impairment, affecting more than a third of individuals over the age of 65. PNSHL includes noise-induced hearing loss (NIHL) and inherited form…
View article: Long-range cis-regulatory elements controlling GDF6 expression are essential for ear development
Long-range cis-regulatory elements controlling GDF6 expression are essential for ear development Open
Molecular mechanisms governing the development of the mammalian cochlea, the hearing organ, remain largely unknown. Through genome sequencing in 3 subjects from 2 families with nonsyndromic cochlear aplasia, we identified homozygous 221-kb…
View article: P372 Bacterial vaginosis and high-risk human papillomavirus coinfection among african american women in the united states
P372 Bacterial vaginosis and high-risk human papillomavirus coinfection among african american women in the united states Open
Background Bacterial vaginosis (BV) increases the risk of many sexually transmitted infections. The co-occurrence of persistent BV and high-risk HPV (HrHPV) increases the risk of developing cervical cancer. This study aims to investigate t…
View article: P371 Effect of metronidazole treatment on recurrent and persistent bacterial vaginosis: a pilot study
P371 Effect of metronidazole treatment on recurrent and persistent bacterial vaginosis: a pilot study Open
Background This study aims to investigate the effect of metronidazole for the treatment of recurrent and persistent bacterial vaginosis (BV). Methods Stored vaginal swabs of 80 African American (AA) women were randomly selected from a prev…
View article: P373 Co-occurrence of bacterial vaginosis and<i>Trichomonas vaginalis</i>among young african american women
P373 Co-occurrence of bacterial vaginosis and<i>Trichomonas vaginalis</i>among young african american women Open
Background While the etiology of bacterial vaginosis (BV) is still not known, it is described as a polymicrobial condition that lacks lactic-acid producing Lactobacillus species with an overgrowth of anaerobic bacteria and elevated vaginal…
View article: Effect of metronidazole on microbiomes associated with asymptomatic bacterial vaginosis
Effect of metronidazole on microbiomes associated with asymptomatic bacterial vaginosis Open
Asymptomatic Bacterial Vaginosis (BV) damages vaginal epithelium increasing risk of sexually-transmitted infections. Gardnerella vaginalis , Atopobium vaginae , Prevotella amnii , P. bivia and Candida albicans are associated with BV. Prese…
View article: Alginate-regulating genes are identified in the clinical cystic fibrosis isolate of<i>Pseudomonas aeruginosa</i>PA2192
Alginate-regulating genes are identified in the clinical cystic fibrosis isolate of<i>Pseudomonas aeruginosa</i>PA2192 Open
Cystic fibrosis (CF) is a genetic disorder that leads to a buildup of mucus in the lungs ideal for bacterial colonization. When Pseudomonas aeruginosa enters the CF lung, it undergoes a conversion from nonmucoid to mucoid; colonization by …