Brett D. Dufour
YOU?
Author Swipe
View article: Hypothalamic volume is associated with dysregulated sleep in autistic and non-autistic young children
Hypothalamic volume is associated with dysregulated sleep in autistic and non-autistic young children Open
Difficulty initiating or maintaining sleep is common among autistic individuals and co-occurs with internalizing and externalizing symptoms. This study tested associations between subcortical regions implicated in sleep processes and measu…
View article: Fragile X cortex is characterized by decreased parvalbumin-expressing interneurons
Fragile X cortex is characterized by decreased parvalbumin-expressing interneurons Open
Fragile X syndrome is a genetic neurodevelopmental disorder caused by a mutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene in the X chromosome. Many fragile X syndrome cases present with autism spectrum disorder and fragil…
View article: <scp>FXTAS</scp> Neuropathology Includes Widespread Reactive Astrogliosis and White Matter Specific Astrocyte Degeneration
<span>FXTAS</span> Neuropathology Includes Widespread Reactive Astrogliosis and White Matter Specific Astrocyte Degeneration Open
Objective Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a late‐onset progressive genetic neurodegenerative disorder that occurs in FMR1 premutation carriers. The temporal, spatial, and cell‐type specific patterns of neurodegenerat…
View article: Insight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on FMR1 Premutation
Insight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on FMR1 Premutation Open
The premutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene is characterized by an expansion of the CGG trinucleotide repeats (55 to 200 CGGs) in the 5’ untranslated region and increased levels of FMR1 mRNA. Molecular mechan…
View article: Insight and Recommendations for Fragile X Premutation Associated Conditions from the 5th International Conference on <em>FMR1</em> Premutation
Insight and Recommendations for Fragile X Premutation Associated Conditions from the 5th International Conference on <em>FMR1</em> Premutation Open
The premutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene is characterized by an expansion of the CGG trinucleotide repeats (55 to 200 CGGs) in the 5' untranslated region, and increased levels of FMR1 mRNA. Molecular …
View article: Synaptic boutons are smaller in chandelier cell cartridges in autism
Synaptic boutons are smaller in chandelier cell cartridges in autism Open
Chandelier (Ch) cells are cortical interneurons with axon terminal structures known as cartridges that synapse on the axon initial segment of excitatory pyramidal neurons. Previous studies indicate that the number of Ch cells is decreased …
View article: Distinct patterns of GABAergic interneuron pathology in autism are associated with intellectual impairment and stereotypic behaviors
Distinct patterns of GABAergic interneuron pathology in autism are associated with intellectual impairment and stereotypic behaviors Open
Autism spectrum disorder is a neurodevelopmental condition characterized by deficits in social communication and repetitive behaviors. How specific anatomical alterations contribute to the clinical profile of autism spectrum disorder remai…
View article: Decreased number and increased activation state of astrocytes in gray and white matter of the prefrontal cortex in autism
Decreased number and increased activation state of astrocytes in gray and white matter of the prefrontal cortex in autism Open
The cerebral cortex presents with alterations in the number of specific cell types in autism spectrum disorder (ASD). Astrocytes have many functions in the brain including a role in higher cognitive functions and in inflammatory brain proc…
View article: Hispano‐American Brain Bank on Neurodevelopmental Disorders: An initiative to promote brain banking, research, education, and outreach in the field of neurodevelopmental disorders
Hispano‐American Brain Bank on Neurodevelopmental Disorders: An initiative to promote brain banking, research, education, and outreach in the field of neurodevelopmental disorders Open
Neurodevelopmental disorders (NDDs) are conditions that present with brain dysfunction due to alterations in the processes of brain development. They present with neuropsychiatric, cognitive, and motor symptoms. Autism spectrum disorder (A…
View article: Neuronal and glial cell number is altered in a cortical layer-specific manner in autism
Neuronal and glial cell number is altered in a cortical layer-specific manner in autism Open
Autism spectrum disorder is a neurodevelopmental condition characterized by impaired social communication and repetitive behaviors. Changes in the number of specific cell types in the cerebral cortex could produce a dramatic alteration in …
View article: Chronic Intermittent Ethanol Activates CHOP in Striatal Microglia and Exacerbates Ethanol Withdrawal
Chronic Intermittent Ethanol Activates CHOP in Striatal Microglia and Exacerbates Ethanol Withdrawal Open
Repeated cycles of alcohol intoxication and withdrawal induce profound changes in gene expression that can contribute to the physiological and behavioral consequences of ethanol. Since neuroinflammation is an important consequence of these…
View article: Fragile X syndrome and associated disorders: Clinical aspects and pathology
Fragile X syndrome and associated disorders: Clinical aspects and pathology Open
This review aims to assemble many years of research and clinical experience in the fields of neurodevelopment and neuroscience to present an up-to-date understanding of the clinical presentation, molecular and brain pathology associated wi…
View article: AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice
AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice Open
The ability of recombinant adeno-associated virus (AAV) to deliver transgenes to the CNS has allowed for several advancements in the field of gene therapy to treat brain disorders. Although most AAVs do not readily cross the blood-brain ba…