Brett Knowles
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View article: Impact of neoadjuvant FOLFIRINOX over upfront resection in borderline resectable pancreatic cancer—an international, multicentre, real-world analysis
Impact of neoadjuvant FOLFIRINOX over upfront resection in borderline resectable pancreatic cancer—an international, multicentre, real-world analysis Open
Background: This study explores the potential benefits of neoadjuvant chemotherapy in borderline resectable (BR) pancreatic adenocarcinoma. Despite neoadjuvant treatment (NAT) increasingly being utilised, uncertainty remains as to the opti…
Liver-specification of human iPSC-derived endothelial cells transplanted into mouse liver Open
Liver sinusoidal endothelial cells (LSECs) play an important role in liver development, regeneration and pathophysiology, but the differentiation process that generates their unique tissue-specific phenotype is poorly understood and diffic…
View article: Telemedicine versus face‐to‐face follow up in general surgery: a randomized controlled trial
Telemedicine versus face‐to‐face follow up in general surgery: a randomized controlled trial Open
Background Telemedicine provides healthcare to patients at a distance from their treating clinician. There is a lack of high‐quality evidence to support the safety and acceptability of telemedicine for postoperative outpatient follow‐up. T…
An algorithm for the management of traumatic abdominal wall hernia based on a <span>9‐year</span> review Open
Background Traumatic abdominal wall hernia (TAWH) is a rare consequence of blunt abdominal trauma, usually in the setting of multitrauma, with little consensus or guidelines for management. We present a case series of patients with traumat…
Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer Open
Patients with colorectal cancer (CRC) frequently develop liver metastases during the course of their disease. A substantial proportion of them receive neoadjuvant FOLFOX (5-Fluorouracil, Oxaliplatin, Leucovorin) prior to surgery in an atte…
The incidence of symptomatic remnant gall bladder: a population study Open
Background Subtotal cholecystectomy is utilized in conditions of high risk to critical structures, like the common bile duct. However, the remnant gall bladder may become symptomatic and require a completion cholecystectomy for treatment. …
Coagulation in liver surgery: an observational haemostatic profile and thromboelastography study Open
Background International normalized ratio (INR) is used as a marker of the haemostatic status following liver resection. However, the impact of liver resection on haemostasis is complex and beyond what can be measured by INR. This study ai…
View article: Duodenal Lipoma Causing Intussusception and Gastric Outlet Obstruction
Duodenal Lipoma Causing Intussusception and Gastric Outlet Obstruction Open
CASE REPORT A 68-year-old woman, with a known history of duodenal lipoma, presented with 1 day of melena and upper abdominal pain without vomiting. A 5.5-cm lipoma in the duodenal bulb (D1) had been confirmed 5 years ago, after incidental …
The Upper Gastrointestinal Cancer Registry (UGICR): a clinical quality registry to monitor and improve care in upper gastrointestinal cancers Open
Purpose The Upper Gastrointestinal Cancer Registry (UGICR) was developed to monitor and improve the quality of care provided to patients with upper gastrointestinal cancers in Australia. Participants It supports four cancer modules: pancre…
View article: Safety, efficacy and compliance of extended thromboprophylaxis in hepatobiliary and upper gastrointestinal surgery
Safety, efficacy and compliance of extended thromboprophylaxis in hepatobiliary and upper gastrointestinal surgery Open
Background Extended venothromboprophylaxis (eVTP) after abdominal surgery for hepatobiliary (HPB) and upper gastrointestinal (UGI) malignancies is recommended. Safety, efficacy and compliance within this group of surgical patients are not …
Management of gallstone pancreatitis in the vagrant liver Open
Management of gallstone pancreatitis in the vagrant liverThe vagrant liver 1 is a rare condition due to laxity or inadequate formation of the coronary and triangular ligaments which normally contribute to its fixation and has been associat…