Explanipedia

Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease Open

David Zhang, Ayodeji Adegunsoye, Justin M. Oldham, Julia Kozlitina, Nicole Garcia , et al. · 2023

Background Studies suggest a harmful pharmacogenomic interaction exists between short leukocyte telomere length (LTL) and immunosuppressants in idiopathic pulmonary fibrosis (IPF). It remains unknown if a similar interaction exists in non-…

Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts Open

Ayodeji Adegunsoye, Chad A. Newton, Justin M. Oldham, Brett Ley, Cathryn T. Lee , et al. · 2023

Pulmonary fibrosis (PF) is characterized by profound scarring and poor survival. We investigated the association of leukocyte telomere length (LTL) with chronological age and mortality across racially diverse PF cohorts. LTL measurements a…

A low-cost, highly functional, emergency use ventilator for the COVID-19 crisis Open

Samuel Raymond, Sam W. Baker, Yuzhe Liu, Mauricio J. Bustamante, Brett Ley , et al. · 2022

Respiratory failure complicates most critically ill patients with COVID-19 and is characterized by heterogeneous pulmonary parenchymal involvement, profound hypoxemia and pulmonary vascular injury. The high incidence of COVID-19 related re…

Peripheral blood leucocyte telomere length is associated with progression of interstitial lung disease in systemic sclerosis Open

Shuo Liu, Melody P. Chung, Brett Ley, Sarah French, Brett M. Elicker , et al. · 2021

Background Peripheral blood leucocyte telomere length (PBL-TL) is associated with outcomes in patients with idiopathic pulmonary fibrosis. Whether PBL-TL is associated with progression of systemic sclerosis-associated interstitial lung dis…

Leukocyte telomere length and mycophenolate therapy in chronic hypersensitivity pneumonitis Open

Ayodeji Adegunsoye, Julie Morisset, Chad A. Newton, Justin M. Oldham, Eric Vittinghoff , et al. · 2020

Recent prospective clinical trials have shown antifibrotic therapies slow lung function decline in patients with idiopathic pulmonary fibrosis (IPF) [1, 2] and progressive fibrosing interstitial lung disease (ILD). Similar findings were de…

A low-cost, rapidly scalable, emergency use ventilator for the COVID-19 crisis Open

Samuel Raymond, Trevor Wesolowski, Sam W. Baker, Yuzhe Liu, Jordan Edmunds , et al. · 2020

For the past 50 years, positive pressure ventilation has been a cornerstone of treatment for respiratory failure. Consensus surrounding the epidemiology of respiratory failure has permitted a relatively good fit between the supply of venti…

Prognostic value of transbronchial lung cryobiopsy for the multidisciplinary diagnosis of idiopathic pulmonary fibrosis: a retrospective validation study Open

Sara Tomassetti, Claudia Ravaglia, Athol U. Wells, Alberto Cavazza, Thomas V. Colby , et al. · 2020

Impact of Idiopathic Pulmonary Fibrosis on Longitudinal Health-care Utilization in a Community-Based Cohort of Patients Open

Erica Farrand, Carlos Iribarren, Eric Vittinghoff, Tory Levine‐Hall, Brett Ley , et al. · 2020

This study defines a marked increase in HRU in patients with IPF compared with control subjects, with accelerated use beginning at least 1 year prediagnosis and elevated use sustained over the following 5 years. To our knowledge, this is t…

Peripheral Blood Leukocyte Telomere Length Predicts Progression of Interstitial Lung Disease Associated with Systemic Sclerosis: Longitudinal Analysis of an Observational Cohort Study with Independent Validation Open

S. Liu, Brett Ley, Sarah French, Brett M. Elicker, Melody P. Chung , et al. · 2020

Telomere length in patients with unclassifiable interstitial lung disease: a cohort study Open

Brett Ley, Shuo Liu, Brett M. Elicker, Travis S. Henry, Eric Vittinghoff , et al. · 2020

Up to 15% of patients with chronic interstitial lung disease (cILD) will remain clinically unclassifiable ( i.e. unclassifiable ILD, uILD) despite thorough clinical evaluation and multidisciplinary team discussion (MDT) [1, 2]. This diagno…

Bronchoalveolar lavage fluid lymphocytosis in chronic hypersensitivity pneumonitis: a systematic review and meta-analysis Open

N.A. Adderley, Christopher Humphreys, Hayley Barnes, Brett Ley, Zahra Premji , et al. · 2020

Background The role of bronchoalveolar lavage fluid (BALF) lymphocyte percentage in diagnosing chronic hypersensitivity pneumonitis (CHP) is unclear. We conducted a systematic review and meta-analysis of bronchoalveolar lavage (BAL) lympho…

Corticosteroid use is not associated with improved outcomes in acute exacerbation of IPF Open

Erica Farrand, Eric Vittinghoff, Brett Ley, Atul J. Butte, Harold R. Collard · 2019

Background and objective AE‐IPF has profound prognostic implications, preceding approximately half of all IPF‐related deaths. Despite this clinical significance, there are limited data to guide management decisions. Corticosteroids remain …

Risk factors for disease progression in idiopathic pulmonary fibrosis Open

Ganesh Raghu, Brett Ley, Kevin M. Brown, Vincent Cottin, Kevin F. Gibson , et al. · 2019

In this retrospective study of a randomised trial of simtuzumab in idiopathic pulmonary fibrosis (IPF), prodromal decline in forced vital capacity (FVC) was significantly associated with increased risk of mortality, respiratory and all-cau…

Concomitant medications and clinical outcomes in idiopathic pulmonary fibrosis Open

Michael Kreuter, David J. Lederer, Vincent Cottin, Nicolas Kahn, Brett Ley , et al. · 2019

Patients with idiopathic pulmonary fibrosis (IPF) frequently have a substantial burden of comorbidities [1]. Antifibrotic therapy is recommended to slow the progression of IPF [2]. Patients receiving antifibrotic therapy frequently receive…

Rebuttal From Dr Ley Open

Brett Ley · 2019

COUNTERPOINT: Should Molecular and Genetic Biomarkers Be Used in the Initial Evaluation of Patients With Fibrotic ILD? No Open

Brett Ley · 2019

Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis Open

Brett Ley, Dara G. Torgerson, Justin M. Oldham, Ayodeji Adegunsoye, Shuo Liu , et al. · 2019

Rationale: Rare genetic variants in telomere-related genes have been identified in familial, idiopathic, and rheumatoid arthritis-associated pulmonary fibrosis. Short peripheral blood leukocyte (PBL) telomere length predicts poor ou…

Pulmonary physiology is poorly associated with radiological extent of disease in systemic sclerosis-associated interstitial lung disease Open

Amrit Jhajj, Harinder Pal Gill, Cameron Hague, Darra Murphy, Brett M. Elicker , et al. · 2019

Trials in systemic sclerosis-associated interstitial lung disease (SSc-ILD) typically use forced vital capacity (FVC) as the primary end-point [1, 2]; however, pulmonary function tests have limitations in SSc-ILD, notably being influenced …

3541 The association of corticosteroid use with inpatient mortality in acute exacerbation of idiopathic pulmonary fibrosis Open

Erica Farrand, Eric Vittinghoff, Brett Ley, Harold R. Collard · 2019

OBJECTIVES/SPECIFIC AIMS: Objective: To assess the impact of corticosteroid therapy on in-hospital mortality in IPF patients admitted with acute respiratory failure. METHODS/STUDY POPULATION: Methods: Patients with IPF were retrospectively…

Significance of bronchiolocentric fibrosis in patients with histopathological usual interstitial pneumonia Open

Kiminobu Tanizawa, Brett Ley, Eric Vittinghoff, Brett M. Elicker, Travis S. Henry , et al. · 2019

Aims To evaluate the clinical significance of bronchiolocentric fibrosis (BCF) in patients with a histopathological pattern of usual interstitial pneumonia (UIP). Methods and results Two hundred and fifty‐two patients with pathological UIP…

Telomere length and genetic variant associations with interstitial lung disease progression and survival Open

Chad A. Newton, Justin M. Oldham, Brett Ley, Vikram Anand, Ayodeji Adegunsoye , et al. · 2019

Leukocyte telomere length (LTL), MUC5B rs35705950 and TOLLIP rs5743890 have been associated with idiopathic pulmonary fibrosis (IPF). In this observational cohort study, we assessed the associations between these genomic markers and outcom…

The added value of comorbidities in predicting survival in idiopathic pulmonary fibrosis: a multicentre observational study Open

Sebastiano Emanuele Torrisi, Brett Ley, Michael Kreuter, Marlies Wijsenbeek, Eric Vittinghoff , et al. · 2018

Background The gender–age–physiology (GAP) model was developed to predict the risk of death. Comorbidities are common in idiopathic pulmonary fibrosis (IPF) and may impact on survival. We evaluated the ability of comorbidities to improve p…

Analysis of pulmonary features and treatment approaches in the COPA syndrome Open

Jessica Tsui, Oscar Estrada, Zimu Deng, Kristin M. Wang, Christopher S. Law , et al. · 2018

The COPA syndrome is a monogenic, autoimmune lung and joint disorder first identified in 2015. This study sought to define the main pulmonary features of the COPA syndrome in an international cohort of patients, analyse patient responses t…

Identification of Diagnostic Criteria for Chronic Hypersensitivity Pneumonitis. An International Modified Delphi Survey Open

Julie Morisset, Kerri A. Johannson, Kirk D. Jones, Paul J. Wolters, Harold R. Collard , et al. · 2017

This consensus-based approach for the diagnosis of cHP represents a first step towards the development of international guidelines for the diagnosis of cHP.

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case–cohort study Open

Simon Walsh, Toby M. Maher, Martin Kolb, Venerino Poletti, Richard Nusser , et al. · 2017

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF e…

The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohort-control study Open

Brett Ley, Chad A. Newton, Isabel Arnould, Brett M. Elicker, Travis S. Henry , et al. · 2017

Mortality Risk Prediction in Scleroderma-Related Interstitial Lung Disease Open

Julie Morisset, Eric Vittinghoff, Brett M. Elicker, Xiaowen Hu, Stephanie T. Le , et al. · 2017

Pirfenidone Reduces Respiratory-related Hospitalizations in Idiopathic Pulmonary Fibrosis Open

Brett Ley, Jeffrey J. Swigris, Bann-mo Day, John L. Stauffer, Karina Raimundo , et al. · 2017

In a pooled analysis of three phase III IPF clinical trials, patients receiving pirfenidone had a lower risk of nonelective respiratory-related hospitalization over the course of 1 year. The effect of pirfenidone on death after hospitaliza…

The performance of the GAP model in patients with rheumatoid arthritis associated interstitial lung disease Open

Julie Morisset, Eric Vittinghoff, Bo Young Lee, Roberto Tonelli, Xiaowen Hu , et al. · 2017

Code-based Diagnostic Algorithms for Idiopathic Pulmonary Fibrosis. Case Validation and Improvement Open

Brett Ley, Thomas H. Urbania, Gail Husson, Eric Vittinghoff, David R. Brush , et al. · 2017

A well-accepted International Classification of Diseases, Ninth Revision, code-based IPF algorithm performs poorly, falsely classifying many non-IPF cases as IPF and missing a substantial proportion of IPF cases. A modification of the IPF …

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