Explanipedia

Population pharmacokinetics of cefazolin administered as prophylaxis in paediatric patients undergoing cardiac surgery Open

Vesa Cheng, Jessica Suna, Xin Liu, Gregory Moloney, Supreet P Marathe , et al. · 2025

Postoperative cefazolin concentrations in paediatric patients undergoing cardiopulmonary bypass are often inadequate to maintain optimal antimicrobial prophylaxis. More frequent postoperative dosing or the use of extended and continuous in…

Associations Between Uraemic Toxins and Gut Microbiota in Adults Initiating Peritoneal Dialysis Open

Philippa James, Jordan Stanford, Ojas V. A. Dixit, Mary Ann Nicdao, Brett McWhinney , et al. · 2025

Declining kidney function contributes to the accumulation of uraemic toxins produced by gut microbiota, leading to the uraemic syndrome. This study aimed to identify associations between uraemic toxins, diet quality, symptoms and the gut m…

Drain fluid iodine as a biomarker of anastomotic leak after low anterior resection in patients undergoing Gastrografin rectal tube flushes and omission of a diverting ileostomy: The GUSH study Open

David A. Clark, Karen Dobeli, Darren R Allen, Brett McWhinney, Michael Lonne , et al. · 2025

Aim Anastomotic leak (AL) is the anathema of colorectal surgery and its occurrence constitutes a serious risk to patients and places a substantial burden on the health system. The analysis of extravasated intraluminal substances in drain f…

The complexities of elexacaftor/tezacaftor/ivacaftor therapeutic drug monitoring in a person with cystic fibrosis and <i>Mycobacterium abscessus</i> pulmonary disease Open

Claire Y Mou, Daniel Henderson, Angela Matson, K. Herd, David W. Reid , et al. · 2025

Therapeutic drug monitoring (TDM) of elexacaftor/tezacaftor/ivacaftor (ETI) remains challenging due to a lack of clarity around the parameters that govern ETI plasma concentrations, whilst the use of concomitant CYP3A inducers rifabutin an…

A glucocorticoid spike derails muscle repair to heterotopic ossification after spinal cord injury Open

Kylie A. Alexander, Hsu‐Wen Tseng, Hong Wa Lao, Dorothée Girard, Valérie Barbier , et al. · 2024

Why severe injury to the central nervous system (CNS) triggers the development of large neurogenic heterotopic ossifications (NHOs) within periarticular muscles remains unknown. We report that spinal cord injury (SCI) triggers a rapid cort…

Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study Open

Jason A. Roberts, Aaron J. Heffernan, Min Chai, Patrick N. A. Harris, Alex Legg , et al. · 2024

Serum ganciclovir drug exposure in children receiving standard ganciclovir dosing Open

Wenyu Yang, Adam Irwin, Heather Weerdenburg, Brett McWhinney, Theresa Cole , et al. · 2024

Intravenous ganciclovir (GCV) is used for the treatment of cytomegalovirus (CMV) infection in immunocompromised children. Although the therapeutic target for treatment is unclear, studies have shown a serum area under the concentration–tim…

Does Age Influence Immunosuppressant Drug Pharmacokinetics in Kidney Transplant Recipients? Open

Amelia R. Cossart, Nicole M. Isbel, Scott B. Campbell, Brett McWhinney, Christine E. Staatz · 2024

Differences in MPA were found with advancing age and may be due to altered kidney function, haematocrit, plasma protein binding and/or drug absorption. Future research should explore specific covariate contributions to this further.

Ivermectin therapy for young children with scabies infection: a multicentre phase 2 non-randomized trial Open

Amanda Gwee, Andrew C. Steer, Khampheng Phongluxa, Chanthaly Luangphaxay, Khanpaseuth Senggnam , et al. · 2024

Project funding provided by a Thrasher Foundation Early Career Research Award.

Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis Open

Ming G. Chai, Quyen Tu, Menino Osbert Cotta, Michelle J. Bauer, Ross Balch , et al. · 2024

Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis Open

Ming G Chai, Quyen Tu, Menino Osbert Cotta, Michelle J. Bauer, Ross Balch , et al. · 2024

Serum Levels of Vitamin C and Thiamin in Children With Suspected Sepsis: A Prospective Observational Cohort Study Open

Brett McWhinney, Jacobus Ungerer, Renate LeMarsey, Natalie Phillips, Sainath Raman , et al. · 2024

OBJECTIVES: Vitamin C and thiamin have been trialed as adjunctive therapies in adults with septic shock but their role in critically ill children is unclear. We assessed serum levels of vitamin C and thiamin in children evaluated for sepsi…

Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis Open

Gene M Chai, Quyen Tu, Menino Osbert Cotta, Michelle J. Bauer, Ross Balch , et al. · 2023

Purpose Early recognition and effective treatment of sepsis improves outcomes in critically ill patients. However, antibiotic exposures are frequently suboptimal in the Intensive Care Unit (ICU) setting. We describe the feasibility of the …

2533. Cerebrospinal Fluid Penetration of Cefazolin and Flucloxacillin in Children Open

Alison Boast, Alice Lei, Kiera Harwood, Gena Gonis, Amanda Di Carlo , et al. · 2023

Background Effective treatment of methicillin-susceptible Staphylococcus aureus meningitis requires antimicrobial penetration into the CSF. Anti-staphylococcal penicillins, including flucloxacillin, are generally recommended as first-line …

Factors associated with higher alcohol concentrations in emergency department presentations: <span>PACE</span> study Open

Cate M Cameron, Kim Vuong, Brett McWhinney, Anna Zournazi, Silvia Manzanero , et al. · 2023

Introduction The health impact from alcohol is of recognised concern, from acute intoxication as well as increased risk of chronic health issues over time. Identifying factors associated with higher alcohol consumption when presenting to t…

Pre-extensively Drug-Resistant Congenital Tuberculosis in an Extremely Premature Baby Open

Alison Boast, Jeu Ann How, Charis Lau, Arun Sett, Damien Gilby , et al. · 2023

We describe a case of congenital tuberculosis in an extremely premature baby, with rapid molecular detection of a pre-extensively drug-resistant (XDR) pattern of drug resistance. The baby was treated successfully with a regimen including b…

Efficiency of dosing software using Bayesian forecasting in achieving target antibiotic exposures in critically ill patients, a prospective cohort study Open

Ming G. Chai, Jason A. Roberts, Christina F. Kelly, Jacobus Ungerer, Brett McWhinney , et al. · 2023

The use of TDM combined with Bayesian forecasting dosing software increases the efficiency for achieving target antibiotic exposures in the ICU. Clinical trials comparing this approach with other dosing strategies are required to further v…

Population Pharmacokinetics of Ganciclovir in Allogeneic Hematopoietic Stem Cell Transplant Patients Open

Philip Selby, Aaron J. Heffernan, David T Yeung, Morgyn S. Warner, Sandra Peake , et al. · 2023

Treatment of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplantation (alloHCT) patients with ganciclovir is complicated by toxicity and resistance. This study aimed to develop an intravenous ganciclovir popula…

Serum Creatinine and Tacrolimus Assessment With VAMS Finger-Prick Microsampling: A Diagnostic Test Study Open

Carla Scuderi, Suzanne L. Parker, Margaret Jacks, George John, Brett McWhinney , et al. · 2023

In this study, VAMS was used to reliably measured tacrolimus and creatinine. This represents a clear opportunity for more frequent and less invasive sampling for patients.

Prevalence of alcohol consumption in emergency presentations: Novel approach using two biomarkers, ethanol and phosphatidylethanol Open

Cate M Cameron, Kim Vuong, Brett McWhinney, Anna Zournazi, Silvia Manzanero , et al. · 2022

Introduction The aim was to determine the prevalence of alcohol‐related presentations to an emergency department (ED) in a major Australian hospital, through a novel surveillance approach using two biomarkers, blood ethanol and phosphatidy…

N‐acetylglutamate synthase deficiency with associated 3‐methylglutaconic aciduria: A case report Open

Arthavan Selvanathan, Kalliope Demetriou, Matthew Lynch, Michelle Lipke, Carolyn Bursle , et al. · 2022

N‐acetylglutamate synthase (NAGS) deficiency is a rare autosomal recessive disorder, which results in the inability to activate the key urea cycle enzyme, carbamoylphosphate synthetase 1 (CPS1). Patients often suffer life‐threatening episo…

Multicenter Population Pharmacokinetic Study of Unbound Ceftriaxone in Critically Ill Patients Open

Aaron J. Heffernan, Fekade B. Sime, Nilesh Kumta, Steven C. Wallis, Brett McWhinney , et al. · 2022

The objective of this study was to describe the total and unbound population pharmacokinetics of ceftriaxone in critically ill adult patients and to define optimized dosing regimens. Total and unbound ceftriaxone concentrations were obtain…

Prevalence of Alcohol Consumption in Emergency department presentations (PACE) in Queensland, Australia, using alcohol biomarkers ethanol and phosphatidylethanol: an observational study protocol Open

Kim Vuong, Silvia Manzanero, Jacobus Ungerer, Gary Mitchell, Brett McWhinney , et al. · 2021

Introduction Alcohol use in patients presenting to the emergency department (ED) is a significant problem in many countries. There is a need for valid and reliable surveillance of the prevalence of alcohol use in patients presenting to the…

Harmonization of LC-MS/MS Measurements of Plasma Free Normetanephrine, Metanephrine, and 3-Methoxytyramine Open

Mirko Peitzsch, Talia Novos, Denise Kaden, Max Kurlbaum, Antonius E. van Herwaarden , et al. · 2021

Background Plasma-free normetanephrine and metanephrine (metanephrines) are the recommended biomarkers for testing of pheochromocytoma and paraganglioma (PPGL). This study evaluated the status of harmonization of liquid chromatography-tand…

Semimechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria Open

Thanaporn Wattanakul, Mark Baker, J. Möhrle, Brett McWhinney, Richard M. Hoglund , et al. · 2021

Dihydroartemisinin-piperaquine is a recommended first-line artemisinin combination therapy for Plasmodium falciparum malaria. Piperaquine is also under consideration for other antimalarial combination therapies.

Population pharmacokinetics of ivermectin for the treatment of scabies in Indigenous Australian children Open

Amanda Gwee, Stephen B. Duffull, Xiao Zhu, Steven Y. C. Tong, Noel Cranswick , et al. · 2020

Ivermectin is a broad-spectrum antiparasitic agent used for the treatment and control of neglected tropical diseases. In Australia, ivermectin is primarily used for scabies and is licensed in children aged ≥5 years weighing >15 kg. However…

Effect of Sodium Benzoate vs Placebo Among Individuals With Early Psychosis Open

James G. Scott, Andrea Baker, Carmen Lim, Sharon Foley, Frances Dark , et al. · 2020

anzctr.org.au Identifier: ACTRN12615000187549.

Population Pharmacokinetics of Unbound and Total Teicoplanin in Critically Ill Pediatric Patients Open

Linda B. S. Aulin, Peter De Paepe, Evelyn Dhont, Annick De Jaeger, Johan Vande Walle , et al. · 2020

Pharmacokinetics of Amoxicillin and Cefepime During Prolonged Intermittent Renal Replacement Therapy: A Case Report Open

Jessica H Xu, Vesa Cheng, Matthew Rawlins, J J Lennon, David Morgan , et al. · 2020

Prolonged intermittent renal replacement therapy (PIRRT) is an emerging form of renal replacement therapy in critically ill patients, but dosing data for antibiotics such as amoxicillin and cefepime are scarce and limited. This case report…

Total pathway to method validation Open

Gerald Woollard, Brett McWhinney, Ronda F. Greaves, Wilson Punyalack · 2020

Brett McWhinney YOU? Author Swipe