Brett N. Adey
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View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease
Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease Open
Depression is a risk factor for the later development of Alzheimer’s disease (AD), but evidence for the genetic relationship is mixed. Assessing depression symptom-specific genetic associations may better clarify this relationship. To addr…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairme…
View article: The genetic overlap between functional impairment and severity of depression and anxiety symptoms
The genetic overlap between functional impairment and severity of depression and anxiety symptoms Open
Background Impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence suggesting that symptom severity and functional im…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: The United Kingdom Eating Disorders Genetics Initiative
The United Kingdom Eating Disorders Genetics Initiative Open
Objective The United Kingdom Eating Disorders Genetics Initiative (EDGI UK), part of the National Institute for Health and Care Research (NIHR) Mental Health BioResource, aims to deepen our understanding of the environmental and genetic et…
View article: Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study
Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study Open
View article: The network structure of mania symptoms differs between people with and without binge eating
The network structure of mania symptoms differs between people with and without binge eating Open
Objectives People with bipolar disorder who also report binge eating have increased psychopathology and greater impairment than those without binge eating. Whether this co‐occurrence is related to binge eating as a symptom or presents diff…
View article: Investigating the genetic relationship between depression symptoms and Alzheimer’s Disease in clinically diagnosed and proxy cases
Investigating the genetic relationship between depression symptoms and Alzheimer’s Disease in clinically diagnosed and proxy cases Open
Depression is a risk factor for Alzheimer’s disease (AD), but evidence for their genetic relationship is mixed. Assessing depression symptom specific genetic associations may better clarify this relationship. Using data from the UK Biobank…
View article: Genetic examination of the Mood Disorder Questionnaire and its relationship with bipolar disorder
Genetic examination of the Mood Disorder Questionnaire and its relationship with bipolar disorder Open
The Mood Disorder Questionnaire (MDQ) is a common screening tool for bipolar disorder that assesses manic symptoms. Its utility for genetic studies of mania or bipolar traits has not been fully examined. We psychometrically compared the MD…
View article: Transcriptomics Analyses of ALS Post-mortem Motor Cortex highlight alteration and potential biomarkers in the Neuropeptide Signalling pathway
Transcriptomics Analyses of ALS Post-mortem Motor Cortex highlight alteration and potential biomarkers in the Neuropeptide Signalling pathway Open
Background Amyotrophic lateral sclerosis (ALS) is a fatal heterogeneous neurodegenerative disease that typically leads to death from respiratory failure within two to five years. Despite the identification of several genetic risk factors, …
View article: Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival
Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival Open
Introduction: Caveolin-1 and Caveolin-2 (CAV1 and CAV2) are proteins associated with intercellular neurotrophic signalling. There is converging evidence that CAV1 and CAV2 (CAV1/2) genes have a role in amyotrophic lateral sclerosis (ALS). …
View article: Additional file 2 of Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study
Additional file 2 of Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study Open
Additional file 2. Output from the statistical models.
View article: Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study
Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study Open
Background: The Genetic Links to Anxiety and Depression (GLAD) Study is a large cohort of individuals with lifetime anxiety and/or depression, designed to facilitate re-contact of participants for mental health research. At the start of th…
View article: Factors associated with anxiety disorder comorbidity
Factors associated with anxiety disorder comorbidity Open
View article: The Eating Disorders Genetics Initiative (EDGI) United Kingdom
The Eating Disorders Genetics Initiative (EDGI) United Kingdom Open
Objective The Eating Disorders Genetics Initiative United Kingdom (EDGI UK), part of the National Institute for Health and Care Research (NIHR) Mental Health BioResource, aims to deepen our understanding of the environmental and genetic ae…
View article: Large-scale Analyses of CAV1 and CAV2 Suggest Their Expression is Higher in Post-mortem ALS Brain Tissue and Affects Survival
Large-scale Analyses of CAV1 and CAV2 Suggest Their Expression is Higher in Post-mortem ALS Brain Tissue and Affects Survival Open
Caveolin-1 and Caveolin-2 (CAV1 and CAV2) are proteins associated with intercellular neurotrophic signalling. There is converging evidence that CAV1 and CAV2 (CAV1/2) genes have a role in ALS. Disease-associated variants have been identifi…
View article: Author Correction: A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex
Author Correction: A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex Open
View article: Depression, anxiety and PTSD symptoms before and during the COVID-19 pandemic in the UK
Depression, anxiety and PTSD symptoms before and during the COVID-19 pandemic in the UK Open
Background The impact of the coronavirus disease 2019 (COVID-19) pandemic on mental health is still being unravelled. It is important to identify which individuals are at greatest risk of worsening symptoms. This study aimed to examine cha…
View article: Comparison of symptom-based versus self-reported diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts
Comparison of symptom-based versus self-reported diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts Open
View article: Age and sex‐related variability in the presentation of generalized anxiety and depression symptoms
Age and sex‐related variability in the presentation of generalized anxiety and depression symptoms Open
Significant age and sex variability suggest that classic diagnostic criteria reflect the presentation most commonly seen in younger males. This study provides avenues for diagnostic adaptation and factor-specific interventions.
View article: A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex
A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex Open
View article: Depression, anxiety and PTSD symptoms before and during the COVID-19 pandemic in the UK
Depression, anxiety and PTSD symptoms before and during the COVID-19 pandemic in the UK Open
Background: The COVID-19 pandemic is a novel population-level stressor. As such, it is important to examine pandemic-related changes in mental health and to identify which individuals are at greatest risk of worsening symptoms.Methods: Onl…
View article: Comparison of algorithm-based versus single-item diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts
Comparison of algorithm-based versus single-item diagnostic measures of anxiety and depression disorders in the GLAD and COPING cohorts Open
Background Understanding and improving outcomes for people with anxiety or depression often requires large studies. To increase participation and reduce costs, such research is typically unable to utilise “gold-standard” methods to ascerta…