Brian Alejandro
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View article: Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B
Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B Open
1. ABSTRACT Zika virus (ZIKV), a member of the Flaviviridae family, causes significant public health concerns through congenital Zika syndrome and Guillain-Barré syndrome, yet no effective anti-ZIKV drugs or vaccines are available. To addr…
View article: Live-attenuated CHIKV vaccine with rearranged genome replicates in vitro and induces immune response in mice
Live-attenuated CHIKV vaccine with rearranged genome replicates in vitro and induces immune response in mice Open
Chikungunya fever virus (CHIKV) is a mosquito-borne alphavirus that causes wide-spread human infections and epidemics in Asia, Africa and recently, in the Americas. CHIKV is considered a priority pathogen by CEPI and WHO. Despite recent ap…
View article: Live-Attenuated CHIKV Vaccine with Rearranged Genome Replicates<i>in vitro</i>and Induces Immune Response in Mice
Live-Attenuated CHIKV Vaccine with Rearranged Genome Replicates<i>in vitro</i>and Induces Immune Response in Mice Open
Chikungunya fever virus (CHIKV) is a mosquito-borne alphavirus that causes wide-spread human infections and epidemics in Asia, Africa and recently, in the Americas. There is no approved vaccine and CHIKV is considered a priority pathogen b…
View article: Non-catastrophic collapse of VEEV by lethal mutagenesis
Non-catastrophic collapse of VEEV by lethal mutagenesis Open
RNA viruses replicate at a high mutation rate, providing a highly adaptive capacity to the population as well as vulnerability to an extinction due to additional mutations, which is the conceptual basis for lethal mutagenesis. However, the…
View article: Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier
Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier Open
Zika virus (ZIKV) can infect and cause microcephaly and Zika-associated neurological complications in the developing fetal and adult brains. In terms of pathogenesis, a critical question is how ZIKV overcomes the barriers separating the br…
View article: Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier
Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier Open
Zika virus (ZIKV) can infect and cause microcephaly and Zika-associated neurological complications in the developing fetal and adult brains. In terms of pathogenesis, a critical question is how ZIKV overcomes the barriers separating the br…