Brian C. Haynes
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View article: Extracellular Vesicle Gene Expression Enables Sensitive Detection of Colorectal Neoplasia
Extracellular Vesicle Gene Expression Enables Sensitive Detection of Colorectal Neoplasia Open
BACKGROUND & AIMS Extracellular vesicles (EVs), including exosomes, are emerging as promising carriers of disease-specific biomarkers due to their molecular cargo reflective of cellular origin. While cell-free DNA (cfDNA) methylation assay…
View article: An Exosomal mRNA Urine Test for Detection and Risk Stratification of Human Kidney Transplant Rejection
An Exosomal mRNA Urine Test for Detection and Risk Stratification of Human Kidney Transplant Rejection Open
View article: Supplementary Table 1 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Table 1 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
XLS file - 131K
View article: Supplementary Figure 4 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Figure 4 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 81K
View article: Supplementary Figure 5 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Figure 5 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 79K
View article: Supplementary Table 4 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Table 4 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 106K
View article: Supplementary Figure 5 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Figure 5 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 79K
View article: Supplementary Table 3 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Table 3 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
XLS file - 35K
View article: Supplementary Figure 1 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Figure 1 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 46K
View article: Data from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Data from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
DICER1 is essential for the generation of mature miRNAs and other short noncoding RNAs. Several lines of investigation implicate DICER1 as a tumor suppressor. Reduced DICER1 levels and changes in miRNA abundance have been associated with a…
View article: Supplementary Figure 3 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Figure 3 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 78K
View article: Supplementary Figure 4 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Figure 4 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 81K
View article: Supplementary Table 1 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Table 1 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
XLS file - 131K
View article: Supplementary Figure 3 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Figure 3 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 78K
View article: Supplementary Table 3 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Table 3 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
XLS file - 35K
View article: Supplementary Figure 1 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Figure 1 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 46K
View article: Supplementary Figure 2 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Figure 2 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 62K
View article: Supplementary Table 2 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Table 2 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
XLS file - 3.1K
View article: Supplementary Table 5 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Table 5 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
XLS file - 10K
View article: Supplementary Table 5 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Table 5 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
XLS file - 10K
View article: Supplementary Table 4 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Table 4 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 106K
View article: Supplementary Table 2 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Table 2 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
XLS file - 3.1K
View article: Supplementary Figure 2 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Supplementary Figure 2 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
PDF file - 62K
View article: Data from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Data from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells Open
DICER1 is essential for the generation of mature miRNAs and other short noncoding RNAs. Several lines of investigation implicate DICER1 as a tumor suppressor. Reduced DICER1 levels and changes in miRNA abundance have been associated with a…
View article: Validation of Fragile X Screening in the Newborn Population Using a Fit-for-Purpose FMR1 PCR Assay System
Validation of Fragile X Screening in the Newborn Population Using a Fit-for-Purpose FMR1 PCR Assay System Open
View article: Multilaboratory Assessment of a New Reference Material for Quality Assurance of Cell-Free Tumor DNA Measurements
Multilaboratory Assessment of a New Reference Material for Quality Assurance of Cell-Free Tumor DNA Measurements Open
View article: An Integrated Next-Generation Sequencing System for Analyzing DNA Mutations, Gene Fusions, and RNA Expression in Lung Cancer
An Integrated Next-Generation Sequencing System for Analyzing DNA Mutations, Gene Fusions, and RNA Expression in Lung Cancer Open
We developed and characterized a next-generation sequencing (NGS) technology for streamlined analysis of DNA and RNA using low-input, low-quality cancer specimens. A single-workflow, targeted NGS panel for non-small cell lung cancer (NSCLC…
View article: Design, Optimization, and Multisite Evaluation of a Targeted Next-Generation Sequencing Assay System for Chimeric RNAs from Gene Fusions and Exon-Skipping Events in Non–Small Cell Lung Cancer
Design, Optimization, and Multisite Evaluation of a Targeted Next-Generation Sequencing Assay System for Chimeric RNAs from Gene Fusions and Exon-Skipping Events in Non–Small Cell Lung Cancer Open
Lung cancer accounts for approximately 14% of all newly diagnosed cancers and is the leading cause of cancer-related deaths. Chimeric RNA resulting from gene fusions (RNA fusions) and other RNA splicing errors are driver events and clinica…
View article: Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host Response
Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host Response Open
Cryptococcus neoformans is a ubiquitous, opportunistic fungal pathogen that kills over 600,000 people annually. Here, we report integrated computational and experimental investigations of the role and mechanisms of transcriptional regulati…
View article: Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies Open
All next-generation sequencing (NGS) procedures include assays performed at the laboratory bench ("wet bench") and data analyses conducted using bioinformatics pipelines ("dry bench"). Both elements are essential to produce accurate and re…