Brian C.‐S. Liu
YOU?
Author Swipe
View article: Antibody profiling with protein antigen microarrays in early stage cancer
Antibody profiling with protein antigen microarrays in early stage cancer Open
The nature of protein microarray platforms is conducive to multiplexing, which amplifies the potential for uncovering effective biomarkers for many significant diseases. However, the major challenge will be in integrating microarray platfo…
View article: CA125 Immune Complexes in Ovarian Cancer Patients with Low CA125 Concentrations
CA125 Immune Complexes in Ovarian Cancer Patients with Low CA125 Concentrations Open
BACKGROUND About 20% of women with ovarian cancer have low concentrations of serum cancer antigen 125 (CA125), and this important tumor marker cannot be used to monitor their disease. The measured concentration for mucin 1 (MUC1), or CA15-…
View article: A Comprehensive Approach Toward Novel Serum Biomarkers for Benign Prostatic Hyperplasia: The MPSA Consortium
A Comprehensive Approach Toward Novel Serum Biomarkers for Benign Prostatic Hyperplasia: The MPSA Consortium Open
These findings and ongoing Consortium discovery efforts have the potential to provide a greater understanding of the defects underlying disease pathology, and may lead to the development of early and more effective pharmacological treatmen…
View article: The “Reverse Capture” Autoantibody Microarray:
The “Reverse Capture” Autoantibody Microarray: Open
Recently, we reported the development and use of a "reverse capture" antibody microarray for the purpose of investigating antigen-autoantibody profiling. This platform was developed to allow researchers to characterize and compare the auto…
View article: The Zinc Finger Protein Ras-Responsive Element Binding Protein-1 Is a Coregulator of the Androgen Receptor: Implications for the Role of the Ras Pathway in Enhancing Androgenic Signaling in Prostate Cancer
The Zinc Finger Protein Ras-Responsive Element Binding Protein-1 Is a Coregulator of the Androgen Receptor: Implications for the Role of the Ras Pathway in Enhancing Androgenic Signaling in Prostate Cancer Open
Androgen receptor (AR) plays an important role in normal prostate function as well as in the etiology of prostate cancer. Activation of AR is dictated by hormone binding and by interactions with coregulators. Several of these coregulators …
View article: A native antigen “reverse capture” microarray platform for autoantibody profiling of prostate cancer sera
A native antigen “reverse capture” microarray platform for autoantibody profiling of prostate cancer sera Open
Cancer sera contain antibodies that react with autologous cellular antigens. Here, we report the use of a novel native antigen‐based platform, the “reverse capture” autoantibody microarray, for identification of autoantigens against which …
View article: Histone deacetylation is directly involved in desilencing the expression of the catalytic subunit of telomerase in normal lung fibroblast
Histone deacetylation is directly involved in desilencing the expression of the catalytic subunit of telomerase in normal lung fibroblast Open
The regulation of telomerase expression in normal cells is poorly understood. Moreover, the molecular mechanism underlying tumor-specific expression of telomerase remains unclear. We investigated the link between histone deacetylation and …
View article: Expression of telomerase subunits in normal and neoplastic prostate epithelial cells isolated by laser capture microdissection
Expression of telomerase subunits in normal and neoplastic prostate epithelial cells isolated by laser capture microdissection Open
Molecular analyses of LCM cells from prostate carcinoma patient samples demonstrated transcriptional up-regulation of all telomerase subunits in the prostatic epithelium. However, only the catalytic subunit of telomerase, hTERT, was found …