Brian C. Samuels
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View article: Early Peripapillary Choroidal Thinning during Myopia Development: A Potential Biomarker for Progressive Myopia Identified in Tree Shrews
Early Peripapillary Choroidal Thinning during Myopia Development: A Potential Biomarker for Progressive Myopia Identified in Tree Shrews Open
Sustained negative lens wear can induce progressive myopia in tree shrews. Profound choroidal thinning during early myopia development is a potential biomarker for future chorioscleral thinning, axial elongation, and myopia progression. Th…
View article: Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia
Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia Open
During experimental high myopia development, progressive relative deformations of ASCO and BMO occur simultaneously with changes in border tissue configuration from internally to externally oblique in sectors that are close to the posterio…
View article: Ocular Pulse Amplitude Correlates With Ocular Rigidity at Native IOP Despite the Variability in Intraocular Pulse Volume With Each Heartbeat
Ocular Pulse Amplitude Correlates With Ocular Rigidity at Native IOP Despite the Variability in Intraocular Pulse Volume With Each Heartbeat Open
Importantly, OPA at native IOP is correlated with ocular rigidity despite the significant variability in PV between heartbeats.
View article: A Potential Role of Acute Choroidal Expansion in Nonarteritic Anterior Ischemic Optic Neuropathy
A Potential Role of Acute Choroidal Expansion in Nonarteritic Anterior Ischemic Optic Neuropathy Open
Acute choroidal expansion caused large deformations of the ONH and these deformations were impacted by choroid geometry. These results are consistent with the concept that compartment syndrome due to the choroid geometry and/or expansion a…
View article: A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest
A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest Open
View article: Dual Orexin Receptor Antagonist Attenuates Increases in IOP, ICP, and Translaminar Pressure Difference After Stimulation of the Hypothalamus in Rats
Dual Orexin Receptor Antagonist Attenuates Increases in IOP, ICP, and Translaminar Pressure Difference After Stimulation of the Hypothalamus in Rats Open
DORAs have the potential to attenuate asynchronous changes in IOP and in ICP and to lessen the extent of TLPDs that may result from central nervous system (CNS) activation.
View article: Anterior Segment Anatomy and Conventional Outflow Physiology of the Tree Shrew (<i>Tupaia belangeri</i>)
Anterior Segment Anatomy and Conventional Outflow Physiology of the Tree Shrew (<i>Tupaia belangeri</i>) Open
These studies lend support to the usefulness of the tree shrew as a novel animal model in anterior segment glaucoma and pharmacology research. The tree shrew's cost, load-bearing collagenous lamina cribrosa, and lack of washout or anterior…
View article: A Novel Tree Shrew Model of Diabetic Retinopathy
A Novel Tree Shrew Model of Diabetic Retinopathy Open
Existing animal models with rod-dominant retinas have shown that hyperglycemia injures neurons, but it is not yet clearly understood how blue cone photoreceptors and retinal ganglion cells (RGCs) deteriorate in patients because of compromi…
View article: IOP regulation in the suprachiasmatic nucleus through glutamatergic and GABAergic neuronal pathways
IOP regulation in the suprachiasmatic nucleus through glutamatergic and GABAergic neuronal pathways Open
View article: Differentiation of tree shrew iPSC-derived retinal ganglion cells using 3D organoid approach
Differentiation of tree shrew iPSC-derived retinal ganglion cells using 3D organoid approach Open
View article: Effects of Multiple Pathological Stimuli on Optic Nerve Head Deformation
Effects of Multiple Pathological Stimuli on Optic Nerve Head Deformation Open
View article: Effects of high myopia on in vivo compliance of anterior scleral canal opening and lamina cribrosa depth in juvenile tree shrews
Effects of high myopia on in vivo compliance of anterior scleral canal opening and lamina cribrosa depth in juvenile tree shrews Open
View article: Longitudinal positional changes of anterior scleral canal opening versus Bruch's membrane opening during high myopia development in juvenile tree shrews
Longitudinal positional changes of anterior scleral canal opening versus Bruch's membrane opening during high myopia development in juvenile tree shrews Open
View article: Effect of Scleral Crosslinking Using Multiple Doses of Genipin on Experimental Progressive Myopia in Tree Shrews
Effect of Scleral Crosslinking Using Multiple Doses of Genipin on Experimental Progressive Myopia in Tree Shrews Open
The results of this preclinical study suggest that scleral crosslinking using genipin can slow myopia progression.
View article: Changes in the Optic Nerve Head and Choroid Over 1 Year of Spaceflight
Changes in the Optic Nerve Head and Choroid Over 1 Year of Spaceflight Open
This report documents the late development of mild optic disc edema in 1 crew member and the progressive development of choroidal folds and optic disc edema in another crew member over the duration of 1 year in low Earth orbit aboard the I…
View article: Electrocardiograms Revealing Epsilon Waves Following Use of Hormone Supplements in Young Cardiac Arrest Patient
Electrocardiograms Revealing Epsilon Waves Following Use of Hormone Supplements in Young Cardiac Arrest Patient Open
View article: Quantification of Translaminar Pressure Gradient (TLPG) With Continuous Wireless Telemetry in Nonhuman Primates (NHPs)
Quantification of Translaminar Pressure Gradient (TLPG) With Continuous Wireless Telemetry in Nonhuman Primates (NHPs) Open
Future studies should consider including CSFP, TLP, and TLPG in addition to IOP as potential risk factors when assessing eye-specific glaucoma susceptibility.
View article: Effect of Body Position on Intraocular Pressure (IOP), Intracranial Pressure (ICP), and Translaminar Pressure (TLP) Via Continuous Wireless Telemetry in Nonhuman Primates (NHPs)
Effect of Body Position on Intraocular Pressure (IOP), Intracranial Pressure (ICP), and Translaminar Pressure (TLP) Via Continuous Wireless Telemetry in Nonhuman Primates (NHPs) Open
TLP change due to body position change is driven more by ICP/CSFP than IOP. IOP, ICP, and TLP variability, coupled with telemetry, should allow us to test the hypotheses that IOP, ICP, or TLP fluctuations contribute independently to glauco…
View article: Longitudinal thickness changes of sclera, choroid, RPE, and retina during high myopia development in juvenile tree shrews
Longitudinal thickness changes of sclera, choroid, RPE, and retina during high myopia development in juvenile tree shrews Open
View article: Microinjection of orexin neuropeptide into the brainstem raphe pallidus elevates intraocular pressure.
Microinjection of orexin neuropeptide into the brainstem raphe pallidus elevates intraocular pressure. Open
View article: Tree shrew retina as a model to study allogenic retinal ganglion cell replacement
Tree shrew retina as a model to study allogenic retinal ganglion cell replacement Open
View article: IOP, Intracranial Pressure, Translaminar Pressure and Translaminar Pressure Gradient Quantified with Continuous Wireless Telemetry in Nonhuman Primates
IOP, Intracranial Pressure, Translaminar Pressure and Translaminar Pressure Gradient Quantified with Continuous Wireless Telemetry in Nonhuman Primates Open
View article: High Myopia Increases IOP-dependent Lamina Cribrosa Beam and Peripapillary Scleral Strains in Tree Shrews
High Myopia Increases IOP-dependent Lamina Cribrosa Beam and Peripapillary Scleral Strains in Tree Shrews Open
View article: Intra-Subject Variability and Diurnal Cycle of Ocular Perfusion Pressure as Characterized by Continuous Telemetry in Nonhuman Primates
Intra-Subject Variability and Diurnal Cycle of Ocular Perfusion Pressure as Characterized by Continuous Telemetry in Nonhuman Primates Open
Average OPP varied widely and exhibited differing diurnal cycles in NHPs, a finding that matches those of prior patient studies and indicates that OPP studies in the NHP model are appropriate. Infrequent snapshot measurements of either IOP…
View article: Association of Long-Duration Spaceflight With Anterior and Posterior Ocular Structure Changes in Astronauts and Their Recovery
Association of Long-Duration Spaceflight With Anterior and Posterior Ocular Structure Changes in Astronauts and Their Recovery Open
This study found that spaceflight-associated peripapillary optic disc edema and choroid thickening were observed bilaterally and occurred in both sexes. In addition, this study documented substantial peripapillary choroid thickening during…
View article: Diurnal Cycle of Translaminar Pressure in Nonhuman Primates Quantified With Continuous Wireless Telemetry
Diurnal Cycle of Translaminar Pressure in Nonhuman Primates Quantified With Continuous Wireless Telemetry Open
The 56% increase in TLP during waking hours in NHPs matches the increase in TLP due to postural change from supine to upright reported previously in humans.
View article: Connective tissue remodeling in myopia and its potential role in increasing risk of glaucoma
Connective tissue remodeling in myopia and its potential role in increasing risk of glaucoma Open
View article: Life Cycle and Lensing of a Macular Microcyst
Life Cycle and Lensing of a Macular Microcyst Open
Introduction: Microscopic details about retinal conditions can provide insight into pathological mechanisms, but these are ordinarily difficult to obtain in situ. We demonstrate how high-resolution imaging and optical modelin…
View article: Scleral crosslinking using genipin can effect normal eye development in tree shrews
Scleral crosslinking using genipin can effect normal eye development in tree shrews Open
View article: Effect of Body Position on IOP, Intracranial Pressure and the Translaminar Pressure Difference Measured with Continuous Wireless Telemetry in Nonhuman Primates
Effect of Body Position on IOP, Intracranial Pressure and the Translaminar Pressure Difference Measured with Continuous Wireless Telemetry in Nonhuman Primates Open