Brian Charlesworth
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View article: A gene-based model of fitness and its implications for genetic variation: Genetic and inbreeding loads
A gene-based model of fitness and its implications for genetic variation: Genetic and inbreeding loads Open
In the companion paper to this, we examined the consequences for patterns of linkage disequilibrium of the “gene” model of fitness, which postulates that the effects of recessive or partially recessive deleterious mutations located at diff…
View article: A gene-based model of fitness and its implications for genetic variation: Linkage disequilibrium
A gene-based model of fitness and its implications for genetic variation: Linkage disequilibrium Open
A widely used model of the effects of mutations on fitness (the “sites” model) assumes that heterozygous recessive or partially recessive deleterious mutations at different sites in a gene complement each other, similarly to mutations in d…
View article: HJ Muller and the Relationship Between Sex Chromosome Degeneration and the Evolution of Dosage Compensation
HJ Muller and the Relationship Between Sex Chromosome Degeneration and the Evolution of Dosage Compensation Open
A lack of recombination in the heterogametic sex between parts or all of newly evolving sex chromosomes results in the gradual accumulation of deleterious mutations on proto-Y or proto-W chromosomes. This “genetic degeneration” is caused b…
View article: A gene-based model of fitness and its implications for genetic variation: genetic and inbreeding loads
A gene-based model of fitness and its implications for genetic variation: genetic and inbreeding loads Open
In the companion paper to this, we examined the consequences for patterns of linkage disequilibrium of the “gene” model of fitness, which postulates that the effects of recessive or partially recessive deleterious mutations located at diff…
View article: A gene-based model of fitness and its implications for genetic variation: linkage disequilibrium
A gene-based model of fitness and its implications for genetic variation: linkage disequilibrium Open
A widely used model of the effects of mutations on fitness (the “sites” model) assumes that heterozygous recessive or partially recessive deleterious mutations at different sites in a gene complement each other, similarly to mutations in d…
View article: Beyond recombination: Exploring the impact of meiotic frequency on genome-wide genetic diversity
Beyond recombination: Exploring the impact of meiotic frequency on genome-wide genetic diversity Open
An important aim of population genetics is to elucidate the processes affecting genetic diversity across regions of the genome and across species. Canonical population genetic models of sexually reproducing species define the rate of meiot…
View article: A model of Hill-Robertson interference caused by purifying selection in a nonrecombining genome
A model of Hill-Robertson interference caused by purifying selection in a nonrecombining genome Open
A new approach to modeling the effects of Hill-Robertson interference on levels of adaptation and patterns of variability in a nonrecombining genome or genomic region is described. The model assumes a set of L diallelic sites subject to re…
View article: Beyond Recombination: Exploring the Impact of Meiotic Frequency on Genome-wide Genetic Diversity
Beyond Recombination: Exploring the Impact of Meiotic Frequency on Genome-wide Genetic Diversity Open
An important aim of population genetics is to elucidate the processes affecting genetic diversity across regions of the genome and across species. Canonical population genetic models of sexually reproducing species define the rate of meiot…
View article: A gene-based model of fitness and its implications for genetic variation: Genetic and inbreeding loads
A gene-based model of fitness and its implications for genetic variation: Genetic and inbreeding loads Open
In the companion paper to this, we examined the consequences for patterns of linkage disequilibrium of the “gene” model of fitness, which postulates that the effects of recessive or partially recessive deleterious mutations located at diff…
View article: Mendelian genetics and eugenics
Mendelian genetics and eugenics Open
View article: A model of Hill-Robertson interference caused by purifying selection in a non-recombining genome
A model of Hill-Robertson interference caused by purifying selection in a non-recombining genome Open
A new approach to modeling the effects of Hill-Robertson interference on levels of adaptation and patterns of variability in a non-recombining genome or genomic region is described. The model assumes a set of L diallelic sites subject to r…
View article: Making sense of recent models of the “sheltering” hypothesis for recombination arrest between sex chromosomes
Making sense of recent models of the “sheltering” hypothesis for recombination arrest between sex chromosomes Open
In their most extreme form, sex chromosomes exhibit a complete lack of genetic recombination along much of their length in the heterogametic sex. Some recent models explain the evolution of such suppressed recombination by the “sheltering”…
View article: A gene-based model of fitness and its implications for genetic variation: Linkage disequilibrium
A gene-based model of fitness and its implications for genetic variation: Linkage disequilibrium Open
A widely used model of the effects of mutations on fitness (the “sites” model) assumes that heterozygous recessive or partially recessive deleterious mutations at different sites in a gene complement each other, similarly to mutations in d…
View article: The fitness consequences of genetic divergence between polymorphic gene arrangements
The fitness consequences of genetic divergence between polymorphic gene arrangements Open
Inversions restrict recombination when heterozygous with standard arrangements, but often have few noticeable phenotypic effects. Nevertheless, there are several examples of inversions that can be maintained polymorphic by strong selection…
View article: Do deleterious mutations promote the evolution of recombination suppression between X and Y chromosomes?
Do deleterious mutations promote the evolution of recombination suppression between X and Y chromosomes? Open
An interesting new model has recently been proposed for the evolution of suppressed recombination between newly evolving X and Y chromosomes, where males are heterozygous for a locus determining sex and females are homozygous (the same pri…
View article: How chromosomal inversions reorient the evolutionary process
How chromosomal inversions reorient the evolutionary process Open
Inversions are structural mutations that reverse the sequence of a chromosome segment and reduce the effective rate of recombination in the heterozygous state. They play a major role in adaptation, as well as in other evolutionary processe…
View article: The fitness consequences of genetic divergence between polymorphic gene arrangements
The fitness consequences of genetic divergence between polymorphic gene arrangements Open
Inversions restrict recombination when heterozygous with standard arrangements, but often have few noticeable phenotypic effects. Nevertheless, there are several examples of inversions that can be maintained polymorphic by strong selection…
View article: The effects of inversion polymorphisms on patterns of neutral genetic diversity
The effects of inversion polymorphisms on patterns of neutral genetic diversity Open
The strong reduction in the frequency of recombination in heterozygotes for an inversion and a standard gene arrangement causes the arrangements to become partially isolated genetically, resulting in sequence divergence between them and ch…
View article: The effects of inversion polymorphisms on patterns of neutral genetic diversity
The effects of inversion polymorphisms on patterns of neutral genetic diversity Open
The strong reduction in the frequency of recombination in heterozygotes for an inversion and a standard gene arrangement causes the arrangements to become partially isolated genetically, resulting in sequence divergence between them and ch…
View article: Population Genetic Considerations Regarding Evidence for Biased Mutation Rates in<i>Arabidopsis thaliana</i>
Population Genetic Considerations Regarding Evidence for Biased Mutation Rates in<i>Arabidopsis thaliana</i> Open
It has recently been proposed that lower mutation rates in gene bodies compared with upstream and downstream sequences in Arabidopsis thaliana are the result of an “adaptive” modification of the rate of beneficial and deleterious mutations…
View article: Author Correction: From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill
Author Correction: From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill Open
View article: Some complexities in interpreting apparent effects of hitchhiking: A commentary on Gompert et al. (2022)
Some complexities in interpreting apparent effects of hitchhiking: A commentary on Gompert et al. (2022) Open
We write to address recent claims by regarding the potentially important and underappreciated phenomena of “indirect selection,” the observation that neutral regions may be affected by natural selection. We argue both that this phenomenon—…
View article: How Can We Resolve Lewontin’s Paradox?
How Can We Resolve Lewontin’s Paradox? Open
We discuss the genetic, demographic, and selective forces that are likely to be at play in restricting observed levels of DNA sequence variation in natural populations to a much smaller range of values than would be expected from the distr…
View article: Recommendations for improving statistical inference in population genomics
Recommendations for improving statistical inference in population genomics Open
The field of population genomics has grown rapidly in response to the recent advent of affordable, large-scale sequencing technologies. As opposed to the situation during the majority of the 20th century, in which the development of theore…
View article: Fisher’s historic 1922 paper <i>On the dominance ratio</i>
Fisher’s historic 1922 paper <i>On the dominance ratio</i> Open
R.A. Fisher’s 1922 paper On the dominance ratio has a strong claim to be the foundation paper for modern population genetics. It greatly influenced subsequent work by Haldane and Wright, and contributed 3 major innovations to the study of …
View article: The effects of weak selection on neutral diversity at linked sites
The effects of weak selection on neutral diversity at linked sites Open
The effects of selection on variability at linked sites have an important influence on levels and patterns of within-population variation across the genome. Most theoretical models of these effects have assumed that selection is sufficient…
View article: The effects of weak selection on neutral diversity at linked sites
The effects of weak selection on neutral diversity at linked sites Open
The effects of selection on variability at linked sites have an important influence on levels and patterns of within-population variation across the genome. Most theoretical models of these effects have assumed that selection is sufficient…
View article: Effects of Selection at Linked Sites on Patterns of Genetic Variability
Effects of Selection at Linked Sites on Patterns of Genetic Variability Open
Patterns of variation and evolution at a given site in a genome can be strongly influenced by the effects of selection at genetically linked sites. In particular, the recombination rates of genomic regions correlate with their amount of wi…
View article: Recommendations for improving statistical inference in population genomics
Recommendations for improving statistical inference in population genomics Open
The field of population genomics has grown rapidly in response to the recent advent of affordable, large-scale sequencing technologies. As opposed to the situation during the majority of the 20th century, in which the development of theore…
View article: Richard C. Lewontin (1929–2021)
Richard C. Lewontin (1929–2021) Open