Brian Coughlin
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View article: Clinical translation of ultrasoft Fleuron™ probes for stable, high-density, and bidirectional brain interfaces
Clinical translation of ultrasoft Fleuron™ probes for stable, high-density, and bidirectional brain interfaces Open
Building brain foundation models to capture the underpinning neural dynamics of human behavior requires large functional neural datasets for training, which current implantable Brain-Computer Interfaces (iBCIs) cannot obtain due to the ins…
View article: Electrocorticography microdisplay for high precision intraoperative brain mapping
Electrocorticography microdisplay for high precision intraoperative brain mapping Open
View article: An electroencephalogram microdisplay to visualize neuronal activity on the brain surface
An electroencephalogram microdisplay to visualize neuronal activity on the brain surface Open
Functional mapping during brain surgery is applied to define brain areas that control critical functions and cannot be removed. Currently, these procedures rely on verbal interactions between the neurosurgeon and electrophysiologist, which…
View article: CNSC-22. CANCER NEUROSCIENCE IN THE OR: ELECTROPHYSIOLOGIC INSIGHTS AT THE TIME OF BRAIN TUMOR RESECTION
CNSC-22. CANCER NEUROSCIENCE IN THE OR: ELECTROPHYSIOLOGIC INSIGHTS AT THE TIME OF BRAIN TUMOR RESECTION Open
Pioneering works by Venkatesh and Venkataramani demonstrated that formation of functional neural-glial synapses fosters development and growth of glial neoplasms. Resultant peritumoral neural hyperexcitability associates with tumor progres…
View article: DREDge: robust motion correction for high-density extracellular recordings across species
DREDge: robust motion correction for high-density extracellular recordings across species Open
High-density microelectrode arrays (MEAs) have opened new possibilities for systems neuroscience in human and non-human animals, but brain tissue motion relative to the array poses a challenge for downstream analyses, particularly in human…
View article: The Brain Electroencephalogram Microdisplay for Precision Neurosurgery
The Brain Electroencephalogram Microdisplay for Precision Neurosurgery Open
Brain surgeries are among the most delicate clinical procedures and must be performed with the most technologically robust and advanced tools. When such surgical procedures are performed in functionally critical regions of the brain, funct…
View article: Sound and light levels in intensive care units in a large urban hospital in the United States
Sound and light levels in intensive care units in a large urban hospital in the United States Open
Intensive care units (ICUs) may disrupt sleep. Quantitative ICU studies of concurrent and continuous sound and light levels and timings remain sparse in part due to the lack of ICU equipment that monitors sound and light. Here, we describe…
View article: Sleep staging in the ICU with heart rate variability and breathing signals. An exploratory cross-sectional study using deep neural networks
Sleep staging in the ICU with heart rate variability and breathing signals. An exploratory cross-sectional study using deep neural networks Open
Introduction: To measure sleep in the intensive care unit (ICU), full polysomnography is impractical, while activity monitoring and subjective assessments are severely confounded. However, sleep is an intensely networked state, and reflect…
View article: High prevalence of sleep-disordered breathing in the intensive care unit — a cross-sectional study
High prevalence of sleep-disordered breathing in the intensive care unit — a cross-sectional study Open
View article: Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep
Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep Open
Consolidation of memory is believed to involve offline replay of neural activity. While amply demonstrated in rodents, evidence for replay in humans, particularly regarding motor memory, is less compelling. To determine whether replay occu…
View article: Magnetic Temporal Interference for Noninvasive Focal Brain Stimulation
Magnetic Temporal Interference for Noninvasive Focal Brain Stimulation Open
Non-invasive stimulation of deep brain regions has been a major goal for neuroscience and neuromodulation in the past three decades. Transcranial magnetic stimulation (TMS), for instance, cannot target deep regions in the brain without act…
View article: Sleep in the Intensive Care Unit through the Lens of Breathing and Heart Rate Variability: A Cross-Sectional Study
Sleep in the Intensive Care Unit through the Lens of Breathing and Heart Rate Variability: A Cross-Sectional Study Open
Background Full polysomnography, the gold standard of sleep measurement, is impractical for widespread use in the intensive care unit (ICU). Wrist-worn actigraphy and subjective sleep assessments do not measure sleep physiology adequately.…
View article: OpBox: Open Source Tools for Simultaneous EEG and EMG Acquisition from Multiple Subjects
OpBox: Open Source Tools for Simultaneous EEG and EMG Acquisition from Multiple Subjects Open
In vivo electrophysiology experiments require the collection of data from multiple subjects, often for extended periods. Studying multiple subjects for extended periods can be made more efficient through simultaneous recordings, but scalin…
View article: Accurate detection of spontaneous seizures using a generalized linear model with external validation
Accurate detection of spontaneous seizures using a generalized linear model with external validation Open
Objective Seizure detection is a major facet of electroencephalography (EEG) analysis in neurocritical care, epilepsy diagnosis and management, and the instantiation of novel therapies such as closed‐loop stimulation or optogenetic control…