Brian D. Kent
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View article: Counselling and Service Utilization Needs Among Grade 12 Senior High School Students in Davao City, Philippines
Counselling and Service Utilization Needs Among Grade 12 Senior High School Students in Davao City, Philippines Open
Aims: The study aimed to determine the counseling needs of Grade 12 Senior High School students from medical school in Davao City, and the extent to which they utilize the school's counseling services. It also examined the relationship bet…
View article: Spinal myelopathies and their contribution to enteric dysfunction
Spinal myelopathies and their contribution to enteric dysfunction Open
Spinal myelopathies, characterized by neurological deficits due to spinal compression in the spinal column, are increasingly common in the aging population. Although spinal myelopathies commonly present with sensory and motor deficits, the…
View article: Venous thromboembolism prophylaxis in patients with intracranial hemorrhage: a systematic review of considerations for neurosurgical management
Venous thromboembolism prophylaxis in patients with intracranial hemorrhage: a systematic review of considerations for neurosurgical management Open
Background: Patients with intracranial hemorrhage (ICH), whether traumatic brain injury (TBI)-induced or spontaneous, present a significant challenge for neurosurgeons, who must carefully balance the risks of both venous thromboembolism (V…
View article: Plain language summary of the SHAMAL study in patients with severe eosinophilic asthma treated with benralizumab
Plain language summary of the SHAMAL study in patients with severe eosinophilic asthma treated with benralizumab Open
What is this summary about? This is a plain language summary of an article originally published in The Lancet, presenting results of the SHAMAL study. SHAMAL was the first study to investigate whether it is safe to lower the dose of inhale…
View article: Does inhaler adherence really matter in severe asthma?
Does inhaler adherence really matter in severe asthma? Open
Inhaled therapies, primarily the inhaled corticosteroid (ICS), have been the cornerstone of asthma treatment since the 1960s. They have been shown to reduce symptom burden, morbidity and mortality, and potentially avoid unnecessary and uns…
View article: Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study
Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study Open
AstraZeneca.
View article: Diagnosing and managing pleural disease
Diagnosing and managing pleural disease Open
This issue of Breathe focuses on the management of pleural disease https://bit.ly/4a7dh1S.
View article: Outcomes of a Fatigue Management Intervention for People With Post COVID-19 Condition
Outcomes of a Fatigue Management Intervention for People With Post COVID-19 Condition Open
Objective Fatigue is identified as one of the most prevalent and persistent problems reported by people with post COVID-19 condition that negatively impacts on everyday living and resumption of pre–COVID-19 lifestyle. A pilot occupational …
View article: P56 Clinical accuracy and risk of harm in asthma related content on TikTok
P56 Clinical accuracy and risk of harm in asthma related content on TikTok Open
Introduction Social media has dramatically changed the way in which the world accesses information. One potential adverse consequences of social media is the risk of disinformation. This is due to the high volume of generated content which…
View article: P2 Intravenous ferric carboxymaltose for the treatment of refractory restless leg syndrome
P2 Intravenous ferric carboxymaltose for the treatment of refractory restless leg syndrome Open
Introduction Restless legs syndrome (RLS) is a common debilitating neurological disorder. Midbrain iron deficiency has been implicated in the pathophysiology of RLS. There is evidence that supports the use of ferric carboxymaltose (FCM) in…
View article: Climate change, the environment and respiratory disease
Climate change, the environment and respiratory disease Open
Respiratory clinicians are no strangers to the concept of both occupational and recreational exposures affecting the lung, but evolving factors like climate change and air quality can also play a critical role in respiratory health.…
View article: Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial
Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial Open
View article: Pulmonary vascular disease for the general respiratory clinician
Pulmonary vascular disease for the general respiratory clinician Open
Pulmonary vascular disease is relevant to many practising respiratory clinicians: ∼1% of the world's population is estimated to have PH, and it is an important consequence of many other respiratory diseases (e.g. COPD, ILD, sleep…
View article: What we do and do not know about managing respiratory disease in pregnancy
What we do and do not know about managing respiratory disease in pregnancy Open
Respiratory disorders are common in pregnant women, but their exclusion from clinical trials makes decisions around pharmacotherapy challenging. Developing programmes designed to improve evidence in pregnancy should be a priority for re…
View article: 1-year quality of life and health-outcomes in patients hospitalised with COVID-19: a longitudinal cohort study
1-year quality of life and health-outcomes in patients hospitalised with COVID-19: a longitudinal cohort study Open
View article: Infectious disease in respiratory medicine
Infectious disease in respiratory medicine Open
COVID-19 has brought respiratory infections into the spotlight, but other infectious diseases remain important causes of respiratory illness and death https://bit.ly/36t6Rhf.
View article: Targeted therapy in respiratory disease
Targeted therapy in respiratory disease Open
Advances in understanding of respiratory diseases have allowed the development of targeted therapies tailored to the individual patient https://bit.ly/3CEhokk.
View article: Emergency medical admissions and COVID-19: impact on 30-day mortality and hospital length of stay
Emergency medical admissions and COVID-19: impact on 30-day mortality and hospital length of stay Open
View article: Non-dipping nocturnal blood pressure correlates with obstructive sleep apnoea severity in normotensive subjects and may reverse with therapy
Non-dipping nocturnal blood pressure correlates with obstructive sleep apnoea severity in normotensive subjects and may reverse with therapy Open
Background Obstructive sleep apnoea (OSA) is strongly associated with systemic hypertension, but there are limited data on the relationship with blood pressure (BP) in normotensive subjects. Here, we examined the relationship of OSA with n…
View article: Practical Applications of FeNO Measurement and Inhaler Monitoring Technologies in the Management of Difficult Asthma
Practical Applications of FeNO Measurement and Inhaler Monitoring Technologies in the Management of Difficult Asthma Open
View article: Real world effectiveness of anti-IL-5/5R therapies is independent of co-eligibility for anti-IgE therapy
Real world effectiveness of anti-IL-5/5R therapies is independent of co-eligibility for anti-IgE therapy Open
In a real-world setting, the clinical response to the anti-IL-5/5R mAbs mepolizumab and benralizumab in patients with severe eosinophilic asthma is independent of co-eligibility with the anti-IgE mAb omalizumabhttps://bit.ly/2NfAitP
View article: Benralizumab after sub‐optimal response to mepolizumab in severe eosinophilic asthma
Benralizumab after sub‐optimal response to mepolizumab in severe eosinophilic asthma Open
Mepolizumab and benralizumab are monoclonal antibodies (mAb) directed against anti-IL-5 and anti-IL5R, respectively, and their use reduces exacerbation rate and maintenance oral corticosteroid (mOCS) requirements in severe eosinophilic ast…
View article: Steroid-sparing effects of benralizumab in patients with eosinophilic granulomatosis with polyangiitis
Steroid-sparing effects of benralizumab in patients with eosinophilic granulomatosis with polyangiitis Open
Benralizumab reduces oral corticosteroid requirements in patients with EGPA and leads to improved patient-reported outcome measures https://bit.ly/2GI0vhf.
View article: Effects of sleep apnea and kidney dysfunction on objective sleep quality in nondialyzed patients with chronic kidney disease: an ESADA study
Effects of sleep apnea and kidney dysfunction on objective sleep quality in nondialyzed patients with chronic kidney disease: an ESADA study Open
View article: Differential Effects of Unscheduled ICS Withdrawal Between Patients Receiving Benralizumab and Mepolizumab
Differential Effects of Unscheduled ICS Withdrawal Between Patients Receiving Benralizumab and Mepolizumab Open
View article: Sleep Characteristics in Patients with Fibrotic Interstitial Lung Disease
Sleep Characteristics in Patients with Fibrotic Interstitial Lung Disease Open
View article: Co-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome
Co-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome Open
Background Exploding head syndrome is a rarely reported benign sensory parasomnia that may nonetheless have significant impact on patients’ quality of life and their perceived well-being. To date, the mechanisms underlying attacks, charact…
View article: Prevalence and recovery of adrenal insufficiency in steroid-dependent asthma patients receiving biologic therapy
Prevalence and recovery of adrenal insufficiency in steroid-dependent asthma patients receiving biologic therapy Open
Adrenal insufficiency is common in previously steroid-dependent asthma patients. Morning serum cortisol is a valid and important first line test which can indicate adrenal insufficiency and can guide who might need dynamic testing.h…
View article: Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)
Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA) Open
View article: Adherence to inhaled corticosteroids and clinical outcomes in mepolizumab therapy for severe asthma
Adherence to inhaled corticosteroids and clinical outcomes in mepolizumab therapy for severe asthma Open
Introduction Inhaled corticosteroids (ICS) achieve disease control in the majority of asthmatic patients, although adherence to prescribed ICS is often poor. Patients with severe eosinophilic asthma may require treatment with oral corticos…