Brian D. Roy
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View article: Effects of Greek Yogurt Supplementation and Exercise on Markers of Bone Turnover and Inflammation in Older Adult Exercisers: An 8-Week Pilot Intervention Trial
Effects of Greek Yogurt Supplementation and Exercise on Markers of Bone Turnover and Inflammation in Older Adult Exercisers: An 8-Week Pilot Intervention Trial Open
Background/Objectives: This 8-week randomized pilot intervention trial examined the effects of Greek yogurt (GY) supplementation on markers of bone turnover and inflammation in older adult exercisers. Methods: A total of 48 participants ag…
View article: Brain‐derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice
Brain‐derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice Open
This study, in vivo and in vitro, investigated the role of brain‐derived neurotrophic factor (BDNF) in skeletal muscle adaptations to aerobic exercise. BDNF is a contraction‐induced protein that may play a role in muscle adaptations to aer…
View article: GSK3 inhibition improves skeletal muscle function and whole-body metabolism in male mouse models of Duchenne muscular dystrophy
GSK3 inhibition improves skeletal muscle function and whole-body metabolism in male mouse models of Duchenne muscular dystrophy Open
View article: Creatine and low-dose lithium supplementation separately alter energy expenditure, body mass, and adipose metabolism for the promotion of thermogenesis
Creatine and low-dose lithium supplementation separately alter energy expenditure, body mass, and adipose metabolism for the promotion of thermogenesis Open
View article: Demographics and Clinical Characteristics of Patients With Intermediate and High-Risk Pulmonary Embolism: A Single-Centre Experience
Demographics and Clinical Characteristics of Patients With Intermediate and High-Risk Pulmonary Embolism: A Single-Centre Experience Open
View article: Changes in Body Mass, Physical Activity, and Dietary Intake during the COVID-19 Pandemic Lockdowns in Canadian University Students
Changes in Body Mass, Physical Activity, and Dietary Intake during the COVID-19 Pandemic Lockdowns in Canadian University Students Open
This study examined changes in body mass and body mass index (BMI), physical activity, and dietary intake in Canadian university students during the first year of the COVID-19 pandemic. Two self-reported recall surveys were conducted: afte…
View article: Correction: Klentrou et al. Circulating Levels of Bone Markers after Short-Term Intense Training with Increased Dairy Consumption in Adolescent Female Athletes. Children 2021, 8, 961
Correction: Klentrou et al. Circulating Levels of Bone Markers after Short-Term Intense Training with Increased Dairy Consumption in Adolescent Female Athletes. Children 2021, 8, 961 Open
There was an error in the original publication [...]
View article: Correction: McKinlay et al. Effects of Post-Exercise Whey Protein Consumption on Recovery Indices in Adolescent Swimmers. Int. J. Environ. Res. Public Health 2020, 17, 7761
Correction: McKinlay et al. Effects of Post-Exercise Whey Protein Consumption on Recovery Indices in Adolescent Swimmers. Int. J. Environ. Res. Public Health 2020, 17, 7761 Open
The authors of “Effects of Post-Exercise Whey Protein Consumption on Recovery Indices in Adolescent Swimmers” report an error in Table 1 of their article [...]
View article: Low-dose lithium supplementation promotes adipose tissue browning and sarco(endo)plasmic reticulum Ca2+ ATPase uncoupling in muscle
Low-dose lithium supplementation promotes adipose tissue browning and sarco(endo)plasmic reticulum Ca2+ ATPase uncoupling in muscle Open
View article: Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice
Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice Open
View article: Creatine O'Clock: Does Timing of Ingestion Really Influence Muscle Mass and Performance?
Creatine O'Clock: Does Timing of Ingestion Really Influence Muscle Mass and Performance? Open
It is well-established that creatine supplementation augments the gains in muscle mass and performance during periods of resistance training. However, whether the timing of creatine ingestion influences these physical and physiological ada…
View article: Creatine O'Clock: Does Timing of Ingestion Really Influence Muscle Mass and Performance?
Creatine O'Clock: Does Timing of Ingestion Really Influence Muscle Mass and Performance? Open
It is well-established that creatine supplementation augments the gains in muscle mass and performance during periods of resistance training. However, whether the timing of creatine ingestion influences these physical and physiological ada…
View article: Intensified training in adolescent female athletes: a crossover study of Greek yogurt effects on indices of recovery
Intensified training in adolescent female athletes: a crossover study of Greek yogurt effects on indices of recovery Open
Background During a period of intensified exercise (e.g. training/identification camps), often undertaken by competitive youth athletes, the maintenance of muscle function and peak performance can become challenging due to an accumulation …
View article: Effects of Creatine Supplementation on Brain Function and Health
Effects of Creatine Supplementation on Brain Function and Health Open
While the vast majority of research involving creatine supplementation has focused on skeletal muscle, there is a small body of accumulating research that has focused on creatine and the brain. Preliminary studies indicate that creatine su…
View article: SERCA function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice
SERCA function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice Open
Summary The DBA/2J (D2) mdx mouse has emerged as a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mdx mouse. Here, we questioned whether sarco(endo)plasmic reticulum Ca 2+ -ATPase (SERCA) f…
View article: Circulating Levels of Bone Markers after Short-Term Intense Training with Increased Dairy Consumption in Adolescent Female Athletes
Circulating Levels of Bone Markers after Short-Term Intense Training with Increased Dairy Consumption in Adolescent Female Athletes Open
Thirteen female adolescent soccer players (14.3 ± 1.3 years) participated in a cross-over, double-blind trial examining the effects of Greek yogurt (GY) consumption on bone biomarkers during 5 days of intense soccer training. The study too…
View article: Creatine Monohydrate Supplementation Increases White Adipose Tissue Mitochondrial Markers in Male and Female Rats in a Depot Specific Manner
Creatine Monohydrate Supplementation Increases White Adipose Tissue Mitochondrial Markers in Male and Female Rats in a Depot Specific Manner Open
White adipose tissue (WAT) is a dynamic endocrine organ that can play a significant role in thermoregulation. WAT has the capacity to adopt structural and functional characteristics of the more metabolically active brown adipose tissue (BA…
View article: Sex- and tissue-dependent creatine uptake in response to different creatine monohydrate doses in male and female Sprague–Dawley rats
Sex- and tissue-dependent creatine uptake in response to different creatine monohydrate doses in male and female Sprague–Dawley rats Open
Sprague–Dawley rats (n = 32) underwent 8-weeks of creatine monohydrate (CM) supplementation (0, 2.5, 5, and 10 g/L). Total creatine (TCr) concentrations in female white fibre-dominant gastrocnemius (WGAS) and cardiac muscle (HRT) were sign…
View article: Effects of Post-Exercise Whey Protein Consumption on Recovery Indices in Adolescent Swimmers
Effects of Post-Exercise Whey Protein Consumption on Recovery Indices in Adolescent Swimmers Open
Purpose: This study examined the effect of whey protein consumption following high-intensity interval swimming (HIIS) on muscle damage, inflammatory cytokines and performance in adolescent swimmers. Methods: Fifty-four swimmers (11–17 year…
View article: GSK3 inhibition with low dose lithium supplementation augments murine muscle fatigue resistance and specific force production
GSK3 inhibition with low dose lithium supplementation augments murine muscle fatigue resistance and specific force production Open
Calcineurin is a Ca2+ -dependent serine/threonine phosphatase that dephosphorylates nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus. In skeletal muscle, calcineurin signaling and NFAT activat…
View article: Low‐dose lithium feeding increases the SERCA2a‐to‐phospholamban ratio, improving SERCA function in murine left ventricles
Low‐dose lithium feeding increases the SERCA2a‐to‐phospholamban ratio, improving SERCA function in murine left ventricles Open
New Findings What is the central question of this study? Inhibition of glycogen synthase kinase‐3 (GSK3) has been shown to improve cardiac SERCA2a function. Lithium can inhibit GSK3, but therapeutic doses used in treating bipolar disorder …
View article: 283 Alterations in Echocardiographic Parameters in Intermediate and High Risk Acute Pulmonary Embolism with Thrombolytic Therapy
283 Alterations in Echocardiographic Parameters in Intermediate and High Risk Acute Pulmonary Embolism with Thrombolytic Therapy Open
View article: A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells
A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells Open
Glycogen synthase kinase 3 (GSK3) slows myogenic differentiation and myoblast fusion partly by inhibiting the Wnt/β-catenin signaling pathway. Lithium, a common medication for bipolar disorder, inhibits GSK3 via Mg+ competition and increas…
View article: Greek Yogurt and 12 Weeks of Exercise Training on Strength, Muscle Thickness and Body Composition in Lean, Untrained, University-Aged Males
Greek Yogurt and 12 Weeks of Exercise Training on Strength, Muscle Thickness and Body Composition in Lean, Untrained, University-Aged Males Open
Milk and/or whey protein plus resistance exercise (RT) increase strength and muscle size, and optimize body composition in adult males and females. Greek yogurt (GY) contains similar muscle-supporting nutrients as milk yet it is different …
View article: Effects of mild whole body hypothermia on self-paced exercise performance
Effects of mild whole body hypothermia on self-paced exercise performance Open
This study examined self-paced, high-intensity exercise during mild hypothermia and whether hyperoxia might offset any potential impairment. Twelve trained males each completed 15-km time trials in three environmental conditions: Neutral (…
View article: 0142 DECREASED REGIONAL HOMOGENEITY IN THE DEFAULT MODE NETWORK IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
0142 DECREASED REGIONAL HOMOGENEITY IN THE DEFAULT MODE NETWORK IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA Open
Obstructive sleep apnea (OSA) subjects show structural brain injury in a set of interacting cortical sites, the ventral medial prefrontal (vMPF), inferior parietal lobule (IPL), and posterior cingulate cortices (PCC). These areas constitut…
View article: Name and sequences of primers.
Name and sequences of primers. Open
View article: Increases in skeletal muscle ATGL and its inhibitor G0S2 following 8 weeks of endurance training in metabolically different rat skeletal muscles
Increases in skeletal muscle ATGL and its inhibitor G0S2 following 8 weeks of endurance training in metabolically different rat skeletal muscles Open
Adipose triglyceride lipase (ATGL) catalyzes the rate-limiting removal of the first fatty acid from a triglyceride. ATGL is activated by comparative gene identification-58 and inhibited by G(0)/G(1) switch gene-2 protein (G0S2). Research i…
View article: Characterization of Lipolytic Inhibitor G(0)/G(1) Switch Gene-2 Protein (G0S2) Expression in Male Sprague-Dawley Rat Skeletal Muscle Compared to Relative Content of Adipose Triglyceride Lipase (ATGL) and Comparitive Gene Identification-58 (CGI-58)
Characterization of Lipolytic Inhibitor G(0)/G(1) Switch Gene-2 Protein (G0S2) Expression in Male Sprague-Dawley Rat Skeletal Muscle Compared to Relative Content of Adipose Triglyceride Lipase (ATGL) and Comparitive Gene Identification-58 (CGI-58) Open
The rate-limiting enzyme in lipolysis, adipose triglyceride lipase (ATGL), is activated by comparative gene identification-58 (CGI-58) and inhibited by the G(0)/G(1) switch gene-2 (G0S2) protein. It is speculated that inhibition of ATGL is…