Brian D. Zoltowski
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View article: Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception
Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception Open
Cryptochromes (CRYs) play critical roles in regulating diverse physiological functions, including circadian rhythms and neuronal firing in light-dependent or -independent fashions. Structural studies of CRYs have highlighted common feature…
View article: Electron spin dynamics guide cell motility
Electron spin dynamics guide cell motility Open
Diverse organisms exploit the geomagnetic field (GMF) for migration. Migrating birds employ an intrinsically quantum mechanical mechanism for detecting the geomagnetic field: absorption of a blue photon generates a radical pair whose two e…
Disrupting FKF1 homodimerization increases FT transcript levels in the evening by enhancing CO stabilization Open
Key message FKF1 dimerization is crucial for proper FT levels to fine-tune flowering time. Attenuating FKF1 homodimerization increased CO abundance by enhancing its COP1 binding, thereby accelerating flowering under long days. Abstract In …
<i>β</i>‐sheets mediate the conformational change and allosteric signal transmission between the <span><i>As</i>LOV2</span> termini Open
Avena sativa phototropin 1 light‐oxygen‐voltage 2 domain ( As LOV2) is a model protein of Per‐Arnt‐Sim (PAS) superfamily, characterized by conformational changes in response to external environmental stimuli. This conformational change beg…
Microsecond Molecular Dynamics Simulations and Markov State Models of Mutation-Induced Allosteric Mechanisms for the Light-Oxygen-Voltage 2 Protein : Revealing Structural Basis of Signal Transmission Induced by Photoactivation of the Light Protein State Open
Avena Sativa phototropin 1 Light-oxygen-voltage 2 domain (AsLOV2) is the model protein of Per-Arnt-Sim (PAS) superfamily, characterized by conformational changes in response to external environmental stimuli. This conformational change is …
Allosteric regulation in STAT3 interdomains is mediated by a rigid core: SH2 domain regulation by CCD in D170A variant Open
Signal Transducer and Activator of Transcription 3 (STAT3) plays a crucial role in cancer development and thus is a viable target for cancer treatment. STAT3 functions as a dimer mediated by phosphorylation of the SRC-homology 2 (SH2) doma…
Allostery in STAT3 Variant D170A is Mediated by a Rigid Core Open
Signal Transducer and Activator of Transcription 3 (STAT3) plays a crucial role in cancer development and thus is a viable target for cancer treatment. STAT3 functions as a dimer mediated by phosphorylation of the SRC-homology 2 (SH2) doma…
Allosteric control of ACE2 peptidase domain dynamics Open
The analysis of molecular dynamics simulation of the angiotensin-converting enzyme 2 peptidase domain via targeted machine learning and REDAN model revealed how the functional motions of this protein can be allosterically controlled.
Dimeric allostery mechanism of the plant circadian clock photoreceptor ZEITLUPE Open
In Arabidopsis thaliana , the Light-Oxygen-Voltage (LOV) domain containing protein ZEITLUPE (ZTL) integrates light quality, intensity, and duration into regulation of the circadian clock. Recent structural and biochemical studies of ZTL in…
Cryptochromes: Photochemical and structural insight into magnetoreception Open
Cryptochromes (CRYs) function as blue light photoreceptors in diverse physiological processes in nearly all kingdoms of life. Over the past several decades, they have emerged as the most likely candidates for light‐dependent magnetorecepti…
Predicting Potential SARS-COV-2 Drugs—In Depth Drug Database Screening Using Deep Neural Network Framework SSnet, Classical Virtual Screening and Docking Open
Severe Acute Respiratory Syndrome Corona Virus 2 has altered life on a global scale. A concerted effort from research labs around the world resulted in the identification of potential pharmaceutical treatments for CoVID-19 using existing d…
SSnet: A Deep Learning Approach for Protein-Ligand Interaction Prediction Open
Computational prediction of Protein-Ligand Interaction (PLI) is an important step in the modern drug discovery pipeline as it mitigates the cost, time, and resources required to screen novel therapeutics. Deep Neural Networks (DNN) have re…
Steric and Electronic Interactions at Gln154 in ZEITLUPE Induce Reorganization of the LOV Domain Dimer Interface Open
Plants measure light quality, intensity, and duration to coordinate growth and development with daily and seasonal changes in environmental conditions; however, the molecular details linking photochemistry to signal transduction remain inc…
Steric Interactions at Gln154 in ZEITLUPE Induce Reorganization of the LOV Domain Dimer Interface Open
Plants measure light, quality, intensity, and duration to coordinate growth and development with daily and seasonal changes in environmental conditions, however, the molecular details linking photochemistry to signal transduction remain in…
Deciphering the Allosteric Process of the <i>Phaeodactylum tricornutum</i> Aureochrome 1a LOV Domain Open
The conformational-driven allosteric protein diatom Phaeodactylum tricornutum aureochrome 1a (PtAu1a) differs from other light-oxygen-voltage (LOV) proteins for its uncommon structural topology. The mechanism of signaling transduction in t…
Deciphering the Allosteric Process of Phaeodactylum tricornutum Aureochrome 1a LOV Domain Open
The conformational-driven allosteric protein diatom Phaeodactylum tricornutum aureochrome 1a (PtAu1a) di ers from other light-oxygen-voltage (LOV) proteins for its uncommon structural topology. The mechanism of signaling transduction in Pt…
Deciphering the Allosteric Process of Phaeodactylum tricornutum Aureochrome 1a LOV Domain Open
The conformational-driven allosteric protein diatom Phaeodactylum tricornutum aureochrome 1a (PtAu1a) di ers from other light-oxygen-voltage (LOV) proteins for its uncommon structural topology. The mechanism of signaling transduction in Pt…
Predicting Potential SARS-COV-2 Drugs - In Depth Drug Database Screening Using Deep Neural Network Framework SSnet, Classical Virtual Screening and Docking Open
Severe Acute Respiratory Syndrome Corona Virus 2 has altered life on a global scale. Currently, research labs around the world are looking for new pharmaceutical treatments by repurposing existing drugs, identifying potential antibody-base…
Predicting Potential SARS-COV-2 Drugs - In Depth Drug Database Screening Using Deep Neural Network Framework SSnet, Classical Virtual Screening and Docking Open
Severe Acute Respiratory Syndrome Corona Virus 2 has altered life on a global scale. A concerted effort from research labs around the world resulted in the identification of potential pharmaceutical treatments for CoVID-19 using existing d…
SSnet: A Deep Learning Approach for Protein-Ligand Interaction Prediction Open
Computational prediction of Protein-Ligand Interaction (PLI) is an important step in the modern drug discovery pipeline as it mitigates the cost, time, and resources required to screen novel therapeutics. Deep Neural Networks (DNN) have re…
Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon Open
Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory birds to navigate using the Earth’s magnetic field. Validation of such a mechanism h…
Allosteric mechanism of the circadian protein Vivid resolved through Markov state model and machine learning analysis Open
The fungal circadian clock photoreceptor Vivid (VVD) contains a photosensitive allosteric light, oxygen, voltage (LOV) domain that undergoes a large N-terminal conformational change. The mechanism by which a blue-light driven covalent bond…
Revealing Hidden Conformational Space of LOV Protein VIVID Through Rigid Residue Scan Simulations Open
VIVID(VVD) protein is a Light-Oxygen-Voltage(LOV) domain in circadian clock system. Upon blue light activation, a covalent bond is formed between VVD residue Cys108 and its cofactor flavin adenine dinucleotide(FAD), and prompts VVD switchi…
Kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis Open
A LOV (Light, Oxygen, or Voltage) domain containing blue-light photoreceptor ZEITLUPE (ZTL) directs circadian timing by degrading clock proteins in plants. Functions hinge upon allosteric differences coupled to the ZTL photocycle; however,…
Author response: Kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract A LOV (Light, Oxygen, or Volt…