Brian J. Day
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View article: Pro-inflammatory and oxidative responses to burn pit relevant desert particulate matter in macrophages: A role for TLR2 signaling
Pro-inflammatory and oxidative responses to burn pit relevant desert particulate matter in macrophages: A role for TLR2 signaling Open
Particulate matter (PM) exposure is linked to many respiratory diseases such as asthma, yet the underlying mechanisms remain unclear. A large number of warfighters deployed to Afghanistan and Iraqi have developed deployment related respira…
View article: Pharmacological elevation of glutathione inhibits status epilepticus-induced neuroinflammation and oxidative injury
Pharmacological elevation of glutathione inhibits status epilepticus-induced neuroinflammation and oxidative injury Open
Glutathione (GSH) is a major endogenous antioxidant, and its depletion has been observed in several brain diseases including epilepsy. Previous studies in our laboratory have shown that dimercaprol (DMP) can elevate GSH via post-translatio…
Oxidative Stress: An Intersection Between Radiation and Sulfur Mustard Lung Injury Open
Nuclear and chemical weapons of mass destruction share both a tragic and beneficial legacy in mankind’s history and health. The horrific health effects of ionizing radiation and mustard gas exposures unleashed during disasters, wars, and c…
Selenocyanate (SeCN−) acts as an efficient competitive substrate for myeloperoxidase and decreases biological damage induced by hypochlorous acid Open
The leukocyte-derived enzyme myeloperoxidase (MPO) is a key component of the innate immune response and mediates the killing of pathogens via the generation of the powerful oxidant hypochlorous acid (HOCl). Unintended or excessive formatio…
View article: Desert particulate matter from Afghanistan increases airway obstruction in human distal lungs exposed to type 2 cytokine IL-13
Desert particulate matter from Afghanistan increases airway obstruction in human distal lungs exposed to type 2 cytokine IL-13 Open
Introduction Deployment related asthma-like symptoms including distal airway obstruction have been described in U.S. military personnel who served in Iraq and Afghanistan. The mechanisms responsible for the development of distal airway obs…
View article: Single cell RNA-sequencing of human precision-cut lung slices: A novel approach to study the effect of vaping and viral infection on lung health
Single cell RNA-sequencing of human precision-cut lung slices: A novel approach to study the effect of vaping and viral infection on lung health Open
Vaping is an increasing health threat in the US and worldwide. The damaging impact of vaping on the human distal lung has been highlighted by the recent epidemic of electronic cigarette or vaping use-associated lung injury (EVALI). The pat…
Lunar Mission Planning and Exploration using NASA’s Moon Trek Portal Open
NASA’s Moon Trek (https://trek.nasa.gov/moon/) is one of a growing number of interactive, browser-based, online portals for planetary data visualization and analysis produced by NASA’s Solar System Treks Project (SSTP). Moon Trek continues…
Higher Education Teaching and Research using NASA’s Solar System Treks Open
NASA's Solar System Treks Project (SSTP) online portals provide web-based suites of interactive visualization and analysis tools to enable mission planners, planetary scientists, students, and the general public to access mapped data produ…
View article: Electronic Cigarette Exposure Increases the Severity of Influenza a Virus Infection via TRAIL Dysregulation in Human Precision-Cut Lung Slices
Electronic Cigarette Exposure Increases the Severity of Influenza a Virus Infection via TRAIL Dysregulation in Human Precision-Cut Lung Slices Open
The use of electronic nicotine dispensing systems (ENDS), also known as electronic cigarettes (ECs), is common among adolescents and young adults with limited knowledge about the detrimental effects on lung health such as respiratory viral…
Celebrate Lunar Science and Exploration with NASA's International #ObserveTheMoon Night Open
Introduction: International Observe the Moon Night is a worldwide public engagement program that has been held annually since 2010. Every autumn, we ask people to observe the Moon and learn about lunar science and exploration. The event oc…
NASA Moon Trek’s New Visualization and Analysis Tools  Open
NASAs Moon Trek (https://trek.nasa.gov/moon/) is one of a growing number of interactive, browser-based, online portals for planetary data visualization and analysis produced by NASAs Solar System Treks Project (SSTP). Moon Trek continues t…
The Use of Thiocyanate Formulations to Create Manganese Porphyrin Antioxidants That Supplement Innate Immunity Open
The innate immune response to infection results in inflammation and oxidative damage, creating a paradox where most anti-inflammatory and antioxidant therapies can further suppress an already inadequate immune response. We have previously …
View article: Single-Cell RNA Sequencing Reveals a Unique Monocyte Population in Bronchoalveolar Lavage Cells of Mice Challenged With Afghanistan Particulate Matter and Allergen
Single-Cell RNA Sequencing Reveals a Unique Monocyte Population in Bronchoalveolar Lavage Cells of Mice Challenged With Afghanistan Particulate Matter and Allergen Open
Upon returning from deployment to Afghanistan, a substantial number of U.S. military personnel report deployment-related lung disease (DRLD) symptoms, including those consistent with an asthma-like airways disease. DRLD is thought to be ca…
View article: Southwest Asia Desert Particulate Matter Exposure Induces Basal Cell Dysfunction and Inflammatory Remodeling of the Mucociliary Airway Epithelium
Southwest Asia Desert Particulate Matter Exposure Induces Basal Cell Dysfunction and Inflammatory Remodeling of the Mucociliary Airway Epithelium Open
RATIONALE Nearly 3 million United States military service members have deployed to Southwest Asia since 2001, and returning personnel have increased rates of new-onset respiratory symptoms and asthma.Frequent dust storms expose deployers t…
Visualization and Analysis of Data from Small-Body Missions with NASA’s Solar System Treks Portals Open
This presentation provides an overview of portals within NASA’s Solar System Treks Project (SSTP) that specifically target small bodies within our Solar System. These, and all of the portals in the suite of Solar System Trek portals, are a…
Nicotine-Free e-Cigarette Vapor Exposure Stimulates IL6 and Mucin Production in Human Primary Small Airway Epithelial Cells Open
Our results suggest that human small airway epithelial cells exposed to nicotine-free e-vapor increase the inflammatory response and mucin production, which may contribute to distal lung airflow limitation and airway obstruction.
Afghanistan Particulate Matter Enhances Pro-Inflammatory Responses in IL-13-Exposed Human Airway Epithelium via TLR2 Signaling Open
Since the start of Afghanistan combat operations in 2001, there has been an increase in complaints of respiratory illnesses in deployed soldiers with no previous history of lung disorders. It is postulated that deployment-related respirato…
View article: A Pilot Study Assessing the Ability of 5-Aminosalicylic Acid to Modulate the Immune Response in Chronic Beryllium Disease
A Pilot Study Assessing the Ability of 5-Aminosalicylic Acid to Modulate the Immune Response in Chronic Beryllium Disease Open
Chronic beryllium disease is a granulomatous lung disease, characterized by the accumulation of macrophages and beryllium-specific CD4+ T-cells that proliferate and produce T-helper cell type 1 cytokines. Previous studies indicate that ber…
Neuroprotective Effects of AEOL10150 in a Rat Organophosphate Model Open
Prolonged seizure activity or status epilepticus (SE) is one of the most critical manifestations of organophosphate exposure. Previous studies in our laboratory have demonstrated that oxidative stress is a critical mediator of SE-induced n…