Brian E. Carlson
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View article: Deep learning-based phenotyping and assessment of treatment responses in heart failure with preserved ejection fraction
Deep learning-based phenotyping and assessment of treatment responses in heart failure with preserved ejection fraction Open
Background Heart failure with preserved ejection fraction (HFpEF) accounts for over half of heart failure cases, yet effective treatments remain limited due to the syndrome’s clinical heterogeneity. Purpose This study aimed to identify dis…
View article: Artificial intelligence for manuscript writing: policies and implementation in cardiovascular journals
Artificial intelligence for manuscript writing: policies and implementation in cardiovascular journals Open
Artificial intelligence (AI) has emerged as a widely used tool for writing, including in scientific research and publications. While its application to cardiovascular research is the focus of numerous studies, the policies related to its u…
View article: Machine learning-based phenotyping and assessment of treatment responses in heart failure with preserved ejection fraction
Machine learning-based phenotyping and assessment of treatment responses in heart failure with preserved ejection fraction Open
View article: Tension-Induced Stiffening of Cytoskeletal Components Regulates Cardiomyocyte Contractility
Tension-Induced Stiffening of Cytoskeletal Components Regulates Cardiomyocyte Contractility Open
Cardiomyocytes continuously experience mechanical stimuli that regulate their contractile behavior and contribute to overall heart function. Despite the importance of mechanotransduction in cardiac physiology, the mechanisms by which cardi…
View article: Identification of digital twins to guide interpretable AI for diagnosis and prognosis in heart failure
Identification of digital twins to guide interpretable AI for diagnosis and prognosis in heart failure Open
View article: Identification of Digital Twins to Guide Interpretable AI for Diagnosis and Prognosis in Heart Failure
Identification of Digital Twins to Guide Interpretable AI for Diagnosis and Prognosis in Heart Failure Open
Summary Background Heart failure (HF) is a highly heterogeneous and complex condition. Although patient care generates vast amounts of clinical data, robust methods to synthesize available data for individualized management are lacking. Me…
View article: Investing in the Bottom Line: The Value Case for Improving Human Experience in Healthcare
Investing in the Bottom Line: The Value Case for Improving Human Experience in Healthcare Open
Investment in human experience is imperative for healthcare organizations. It is a strategic focus that can lead to great benefits. Those that overlook experience, seeing it as “simply” about satisfaction or survey data, do so at great cos…
View article: In Vitro and in Silico Models of Fibrotic Cardiomyopathy Reveal Ion Channels Controlling Fibroblasts/Cardiomyocyte Crosstalk
In Vitro and in Silico Models of Fibrotic Cardiomyopathy Reveal Ion Channels Controlling Fibroblasts/Cardiomyocyte Crosstalk Open
View article: The Importance of Incorporating Ventricular-Ventricular Interaction (VVI) in the Study of Pulmonary Hypertension
The Importance of Incorporating Ventricular-Ventricular Interaction (VVI) in the Study of Pulmonary Hypertension Open
View article: Integrated Modeling and Simulation of Recruitment of Myocardial Perfusion and Oxygen Delivery in Exercise
Integrated Modeling and Simulation of Recruitment of Myocardial Perfusion and Oxygen Delivery in Exercise Open
View article: Mischief, Malevolence, or Indifference? How Competitors and Adversaries Could Exploit Climate-Related Conflict in the U.S. Central Command Area of Responsibility
Mischief, Malevolence, or Indifference? How Competitors and Adversaries Could Exploit Climate-Related Conflict in the U.S. Central Command Area of Responsibility Open
A variety of potential conflicts in the U.S. Central Command area of responsibility, ranging from civil unrest to intrastate wars and even to interstate wars, could be related to climate change. Climate change could also exacerbate existin…
View article: Teamwork that affects outcomes: A method to enhance team ownership
Teamwork that affects outcomes: A method to enhance team ownership Open
Healthcare is the ultimate team sport, and this case study explores how to build teamwork across teams. The ability for nursing, environmental services and food and nutrition services to work collaboratively to benefit patients is paramoun…
View article: Phenotyping heart failure using model‐based analysis and physiology‐informed machine learning
Phenotyping heart failure using model‐based analysis and physiology‐informed machine learning Open
To phenotype mechanistic differences between heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction, a closed‐loop model of the cardiovascular system coupled with patient‐specific transthoracic echocardiography (TTE) an…
View article: Phenotyping heart failure using model-based analysis and physiology-informed machine learning
Phenotyping heart failure using model-based analysis and physiology-informed machine learning Open
To determine the underlying mechanistic differences between diagnoses of Heart Failure (HF) and specifically heart failure with reduced and preserved ejection fraction (HFrEF & HFpEF), a closed loop model of the cardiovascular system coupl…
View article: Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats
Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats Open
The spontaneously hypertensive rat (SHR) is a genetic model of primary hypertension with an etiology that includes sympathetic overdrive. To elucidate the neurogenic mechanisms underlying the pathophysiology of this model, we analyzed the …
View article: Deep phenotyping of cardiac function in heart transplant patients using cardiovascular system models
Deep phenotyping of cardiac function in heart transplant patients using cardiovascular system models Open
Key points Right heart catheterization data from clinical records of heart transplant patients are used to identify patient‐specific models of the cardiovascular system. These patient‐specific cardiovascular models represent a snapshot of …
View article: Repeating Crossbow Optimization
Repeating Crossbow Optimization Open
The geometry and other properties of a repeating crossbow was optimized in order to maximize the output power. This article focuses mostly on the geometry of the 3-bar mechanism that distinguishes repeating crossbows from tradition…
View article: Seven steps to successful change: How a large academic medical center prepared patients for organizational change
Seven steps to successful change: How a large academic medical center prepared patients for organizational change Open
Vanderbilt University Medical Center (VUMC) launched a new electronic health record (EHR) in a “big bang” implementation that saw the new software go live across multiple hospitals, clinics and geographic locations in a single morning. The…
View article: Model annotation and discovery with the Physiome Model Repository
Model annotation and discovery with the Physiome Model Repository Open
View article: A simulation study of left ventricular decompression using a double lumen arterial cannula prototype during a veno-arterial extracorporeal membrane oxygenation
A simulation study of left ventricular decompression using a double lumen arterial cannula prototype during a veno-arterial extracorporeal membrane oxygenation Open
Background: Veno-arterial extracorporeal membrane oxygenation can be vital to support patients in severe or rapidly progressing cardiogenic shock. In cases of left ventricular distension, left ventricular decompression during veno-arterial…
View article: Deep phenotyping of cardiac function in heart transplant patients using cardiovascular systems models
Deep phenotyping of cardiac function in heart transplant patients using cardiovascular systems models Open
Heart transplant patients are followed with periodic right heart catheterizations (RHCs) to identify post-transplant complications and guide treatment. Post-transplant positive outcomes are associated with a steady reduction of right ventr…
View article: Deep phenotyping of cardiac function in heart transplant patients using\n cardiovascular systems models
Deep phenotyping of cardiac function in heart transplant patients using\n cardiovascular systems models Open
Heart transplant patients are followed with periodic right heart\ncatheterizations (RHCs) to identify post-transplant complications and guide\ntreatment. Post-transplant positive outcomes are associated with a steady\nreduction of right ve…
View article: Model Annotation and Discovery with the Physiome Model Repository
Model Annotation and Discovery with the Physiome Model Repository Open
Motivation: Mathematics and physics based computational models have the potential to help interpret and encapsulate biological phenomena in a computable and reproducible form. Similarly, comprehensive descriptions of such models encoded in…
View article: High salt diet impairs cerebral blood flow regulation via salt‐induced angiotensin <scp>II</scp> suppression
High salt diet impairs cerebral blood flow regulation via salt‐induced angiotensin <span>II</span> suppression Open
Objectives This study sought to determine whether salt‐induced ANG II suppression contributes to impaired CBF autoregulation. Methods Cerebral autoregulation was evaluated with LDF during graded reductions of blood pressure. Autoregulatory…
View article: SemGen: a tool for semantics-based annotation and composition of biosimulation models
SemGen: a tool for semantics-based annotation and composition of biosimulation models Open
Summary As the number and complexity of biosimulation models grows, so do demands for tools that can help users understand models and compose more comprehensive and accurate systems from existing models. SemGen is a tool for semantics-base…
View article: Practical identifiability and uncertainty quantification of a pulsatile cardiovascular model
Practical identifiability and uncertainty quantification of a pulsatile cardiovascular model Open
View article: Investigating Hypotheses through Discovery of Relevant Models of Epithelial Transport
Investigating Hypotheses through Discovery of Relevant Models of Epithelial Transport Open
Scientists often utilize computational models to help understand experimental observations or to investigate hypotheses in ways that are not practically achievable experimentally. The first step in constructing such models is to discover e…
View article: Simulating Drug-Induced Arrhythmia Sensitivity using an Expression-Based Theoretical Model of Human IPSC-Derived Cardiomyocytes
Simulating Drug-Induced Arrhythmia Sensitivity using an Expression-Based Theoretical Model of Human IPSC-Derived Cardiomyocytes Open
View article: Computational Model for Simulating Drug-Induced Arrhythmia Sensitivity of Human iPSC-derived Cardiomyocytes
Computational Model for Simulating Drug-Induced Arrhythmia Sensitivity of Human iPSC-derived Cardiomyocytes Open
A mathematical model describing the electrophysiology and ion handling of cardiomyocytes is a complement to experimental analysis predicting drug-induced proarrhythmic potential in humans as proposed by Comprehensive in vitro Proarrhythmia…
View article: Computational modeling for cardiac safety pharmacology analysis: Contribution of fibroblasts
Computational modeling for cardiac safety pharmacology analysis: Contribution of fibroblasts Open