Brian J. Smith
YOU?
Author Swipe
View article: Engineering tunable GTP/TPi-responsive liposomes through liposomal membrane modulation using a bis-triphenylphosphonium lipid switch
Engineering tunable GTP/TPi-responsive liposomes through liposomal membrane modulation using a bis-triphenylphosphonium lipid switch Open
Liposomes incorporating a bis-phosphonium lipid switch exhibit tunable cargo release triggered by GTP or TPi. Modulating lipid ratios within the liposome controls metabolite selectivity and release kinetics for responsive cargo delivery.
View article: Cone snail venom-inspired somatostatin receptor 4 (SSTR4) agonists as new drug leads for peripheral pain
Cone snail venom-inspired somatostatin receptor 4 (SSTR4) agonists as new drug leads for peripheral pain Open
Persistent pain affects one in five people worldwide, often with severely debilitating consequences. While current treatments can be effective for mild or acute pain, they are largely inadequate for managing moderate to severe chronic pain…
View article: Cage Amine Superbases: Synthesis and Studies of Nona(ethylene)Hexamine and Dodeka(ethylene)Octamine
Cage Amine Superbases: Synthesis and Studies of Nona(ethylene)Hexamine and Dodeka(ethylene)Octamine Open
The cage‐amine molecules nona(ethylene)hexamine and dodeka(ethylene)octamine, have been prepared by coupling 1,4,7‐triazacyclononane (tacn) or 1,4,7,10‐tetraazacyclododecane (cyclen) to the corresponding α‐chloroacetamide derivatives of th…
View article: Development of a novel therapy for systolic heart failure
Development of a novel therapy for systolic heart failure Open
Heart failure presents a critical health challenge with a 5-year mortality rate of up to 50%. Conventional treatments often lead to bradycardia or hypotension due to their impact on patient hemodynamics. To address this issue, we utilized …
View article: Determination of Protein–Ligand Binding Affinities by Thermal Shift Assay
Determination of Protein–Ligand Binding Affinities by Thermal Shift Assay Open
Quantification of protein-ligand interactions is crucial for understanding the protein's biological function and for drug discovery. In this study, we employed three distinct approaches for determination of protein-ligand binding affinitie…
View article: Bibliometric Analysis of the Composition of Landmark Cerebral Venous Sinus Thrombosis Research
Bibliometric Analysis of the Composition of Landmark Cerebral Venous Sinus Thrombosis Research Open
Our study detailed the 100 most-cited articles on CVST in the past 50 years. Understanding top-contributing countries, authors, and journals may help guide the direction of future research in CVST and encourage collaboration within the fie…
View article: Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis
Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis Open
BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial ch…
View article: Venom-inspired somatostatin receptor 4 (SSTR4) agonists as new drug leads for peripheral pain conditions
Venom-inspired somatostatin receptor 4 (SSTR4) agonists as new drug leads for peripheral pain conditions Open
Persistent pain affects one in five people worldwide, often with severely debilitating consequences. Current treatment options, which can be effective for mild or acute pain, are ill-suited for moderate-to-severe persistent pain, resulting…
View article: Molecular definition of the BAK:VDAC2 interaction as a target to manipulate apoptosis
Molecular definition of the BAK:VDAC2 interaction as a target to manipulate apoptosis Open
BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial po…
View article: CCDC 2277359: Experimental Crystal Structure Determination
CCDC 2277359: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Peeling fingernails in a 5‐year‐old
Peeling fingernails in a 5‐year‐old Open
View article: Data from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Data from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
Purpose: Anti-CD20 mAb therapies, including rituximab and obinutuzumab (GA101), are common treatments for follicular lymphoma. In an effort to better understand the role of complement in mAb action, we recently performed germline SN…
View article: Table S2 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Table S2 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
GAUSS patient demographics
View article: Table S3 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Table S3 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
GAUSS response by genotype
View article: Table S3 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Table S3 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
GAUSS response by genotype
View article: Table S2 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Table S2 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
GAUSS patient demographics
View article: Figure S1 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Figure S1 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
Serum protein expression levels by genotype
View article: Table S4 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Table S4 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
GAUSS protein and PFS
View article: Table S1 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Table S1 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
SPORE study population
View article: Table S4 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Table S4 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
GAUSS protein and PFS
View article: Figure S2 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Figure S2 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
GAUSS progression free survival by genotype
View article: Frigure S3 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Frigure S3 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
Serum protein expression levels by best overall response
View article: Figure S2 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Figure S2 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
GAUSS progression free survival by genotype
View article: Table S1 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Table S1 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
SPORE study population
View article: Frigure S3 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Frigure S3 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
Serum protein expression levels by best overall response
View article: Figure S1 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy
Figure S1 from Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy Open
Serum protein expression levels by genotype
View article: The functional evolution of architecturally different plant geranyl diphosphate synthases from geranylgeranyl diphosphate synthase
The functional evolution of architecturally different plant geranyl diphosphate synthases from geranylgeranyl diphosphate synthase Open
Terpenoids constitute the largest class of plant primary and secondary metabolites with a broad range of biological and ecological functions. They are synthesized from isopentenyl diphosphate and dimethylallyl diphosphate, which in plastid…
View article: Abstract 1259: TRIM33 as a novel reader of metabolically-derived histone lactylation
Abstract 1259: TRIM33 as a novel reader of metabolically-derived histone lactylation Open
View article: Abstract 1294: Cancer-associated missense mutations in the tumor suppressor Polybromo-1 variably affect protein stability and function
Abstract 1294: Cancer-associated missense mutations in the tumor suppressor Polybromo-1 variably affect protein stability and function Open
View article: Single-chain insulin analogs threaded by the insulin receptor αCT domain
Single-chain insulin analogs threaded by the insulin receptor αCT domain Open