Brian Fabella
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View article: Optogenetic interrogation of the zebrafish lateral line reveals brain-wide neural circuits involved in pattern separation
Optogenetic interrogation of the zebrafish lateral line reveals brain-wide neural circuits involved in pattern separation Open
View article: Optogenetic interrogation of the zebrafish lateral line reveals brainwide neural circuits involved in pattern separation
Optogenetic interrogation of the zebrafish lateral line reveals brainwide neural circuits involved in pattern separation Open
View article: Amplification through local critical behavior in the mammalian cochlea
Amplification through local critical behavior in the mammalian cochlea Open
Hearing hinges upon the ear’s ability to enhance its responsiveness by means of an energy-expending active process that amplifies the very mechanical inputs that it detects. This process is defined by four properties that, although seeming…
View article: Toward an ex vivo preparation for studies of the cochlear active process in mammals
Toward an ex vivo preparation for studies of the cochlear active process in mammals Open
The mammalian cochlea benefits from an active process characterized by amplification of mechanical inputs, sharp frequency selectivity, compressive nonlinearity, and spontaneous otoacoustic emission. Similar traits are observed in individu…
View article: Influence of Myosin Regulatory Light Chain and Myosin Light Chain Kinase on the Physiological Function of Inner Ear Hair Cells
Influence of Myosin Regulatory Light Chain and Myosin Light Chain Kinase on the Physiological Function of Inner Ear Hair Cells Open
Purpose In the receptor organs of the inner ear, hair cells detect mechanical stimuli such as sounds and accelerations by deflection of their hair bundles. Myosin regulatory light chain (RLC) and non-muscle myosin II (NM2) are expressed at…
View article: Optogenetic interrogation of the lateral-line sensory system reveals mechanisms of pattern separation in the zebrafish brain
Optogenetic interrogation of the lateral-line sensory system reveals mechanisms of pattern separation in the zebrafish brain Open
The ability of animals to interact with their environment hinges on the brain’s capacity to distinguish between patterns of sensory information and accurately attribute them to specific sensory organs. The mechanisms by which neuronal circ…
View article: Critical Behavior through Local Amplification in the Mammalian Cochlea
Critical Behavior through Local Amplification in the Mammalian Cochlea Open
The mammalian cochlea achieves a remarkable feat: over a frequency range of tens of kilohertz, it can detect oscillations of the eardrum as small as a hydrogen atom as well as thunderclaps a trillion times as loud. These remarkable capabil…
View article: Influence of myosin regulatory light chain and myosin light chain kinase on hair cells of the inner ear
Influence of myosin regulatory light chain and myosin light chain kinase on hair cells of the inner ear Open
In the receptor organs of the inner ear and lateral line, sensory hair cells detect mechanical stimuli such as sounds, accelerations, and water movements. In each instance a stimulus deflects the hair bundle, a hair cell’s mechanically sen…
View article: The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear
The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear Open
View article: Thermal Excitation of the Mechanotransduction Apparatus of Hair Cells
Thermal Excitation of the Mechanotransduction Apparatus of Hair Cells Open
View article: Stimulation of hair cells with ultraviolet light
Stimulation of hair cells with ultraviolet light Open
Hair bundles are specialized organelles that transduce mechanical inputs into electrical outputs. To activate hair cells, physiologists have resorted to mechanical methods of hair-bundle stimulation. Here we describe a new method of hair-b…
View article: GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus
GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus Open
Gap detection or gap pre-pulse inhibition of the acoustic startle (GPIAS) has been successfully used in rat and guinea pig models of tinnitus, yet this system has been proven to have low efficacy in CBA mice, with low basal GPIAS and subtl…
View article: Direct mechanical stimulation of tip links in hair cells through DNA tethers
Direct mechanical stimulation of tip links in hair cells through DNA tethers Open
Mechanoelectrical transduction by hair cells commences with hair-bundle deflection, which is postulated to tense filamentous tip links connected to transduction channels. Because direct mechanical stimulation of tip links has not been expe…
View article: Author response: Direct mechanical stimulation of tip links in hair cells through DNA tethers
Author response: Direct mechanical stimulation of tip links in hair cells through DNA tethers Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Mechanoelectrical transduction b…
View article: NOVA2-mediated RNA regulation is required for axonal pathfinding during development
NOVA2-mediated RNA regulation is required for axonal pathfinding during development Open
The neuron specific RNA-binding proteins NOVA1 and NOVA2 are highly homologous alternative splicing regulators. NOVA proteins regulate at least 700 alternative splicing events in vivo, yet relatively little is known about the biologic cons…
View article: Author response: NOVA2-mediated RNA regulation is required for axonal pathfinding during development
Author response: NOVA2-mediated RNA regulation is required for axonal pathfinding during development Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Material and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The neuron spec…
View article: Control of a hair bundle’s mechanosensory function by its mechanical load
Control of a hair bundle’s mechanosensory function by its mechanical load Open
Significance Hair bundles are the sensory antennae that detect different types of mechanical signals in diverse sensory systems of vertebrates. Here we design and use a mechanical-load clamp to show that the mechanical properties of hair b…
View article: Manipulation with Magnetic Tweezers of Mechanosensitive Ion Channels and Adaptation Motors in Hair Cells of the Inner Ear
Manipulation with Magnetic Tweezers of Mechanosensitive Ion Channels and Adaptation Motors in Hair Cells of the Inner Ear Open
View article: Characterization of active hair-bundle motility by a mechanical-load clamp
Characterization of active hair-bundle motility by a mechanical-load clamp Open
Active hair-bundle motility endows hair cells with several traits that augment auditory stimuli. The activity of a hair bundle might be controlled by adjusting its mechanical properties. Indeed, the mechanical properties of bundles vary be…