Brian Fochtman
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View article: Communicating Regulatory High Throughput Sequencing Data Using BioCompute Objects
Communicating Regulatory High Throughput Sequencing Data Using BioCompute Objects Open
For regulatory submissions of next generation sequencing (NGS) data it is vital for the analysis workflow to be robust, reproducible, and understandable. This project demonstrates that the use of the IEEE 2791-2020 Standard, (BioCompute ob…
View article: GlyGen data model and processing workflow
GlyGen data model and processing workflow Open
Summary Glycoinformatics plays a major role in glycobiology research, and the development of a comprehensive glycoinformatics knowledgebase is critical. This application note describes the GlyGen data model, processing workflow and the dat…
View article: GlyGen: Computational and Informatics Resources for Glycoscience
GlyGen: Computational and Informatics Resources for Glycoscience Open
This FAIRsharing record describes: GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data. GlyGen retrieves information from multiple international data sources and integrates and harmonizes…
View article: Baseline human gut microbiota profile in healthy people and standard reporting template
Baseline human gut microbiota profile in healthy people and standard reporting template Open
A comprehensive knowledge of the types and ratios of microbes that inhabit the healthy human gut is necessary before any kind of pre-clinical or clinical study can be performed that attempts to alter the microbiome to treat a condition or …
View article: Baseline human gut microbiota profile in healthy people and standard reporting template
Baseline human gut microbiota profile in healthy people and standard reporting template Open
A comprehensive knowledge of the types and ratios of microbes that inhabit the healthy human gut is necessary before any kind of pre-clinical or clinical study can be performed that attempts to alter the microbiome to treat a condition or …
View article: Customizable <i>de novo</i> design strategies for DOCK: Application to HIVgp41 and other therapeutic targets
Customizable <i>de novo</i> design strategies for DOCK: Application to HIVgp41 and other therapeutic targets Open
De novo design can be used to explore vast areas of chemical space in computational lead discovery. As a complement to virtual screening, from‐scratch construction of molecules is not limited to compounds in pre‐existing vendor catalogs. H…
View article: Inhibition of HIV Entry by Targeting the Envelope Transmembrane Subunit gp41
Inhibition of HIV Entry by Targeting the Envelope Transmembrane Subunit gp41 Open
The fusogenic protein, gp41 has been extensively studied as a promising target to inhibit membrane fusion between the virus and target cells. At the same time, it is a challenging target because the vulnerable conformations of the protein …