Brian G. Czito
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View article: Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology
Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology Open
Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, the intraduodenal portion of the bile duct, and the intraduodenal portion of the pancreatic duct), while periampullary cancers may arise from locations e…
View article: Data from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma
Data from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma Open
Purpose:In this prospective trial, we sought to assess the feasibility of concurrent administration of ipilimumab and radiation as adjuvant, neoadjuvant, or definitive therapy in patients with regionally advanced melanoma.Patients and Meth…
View article: Related Article from Epigenetic Markers in Rectal Cancer
Related Article from Epigenetic Markers in Rectal Cancer Open
Related Article from Epigenetic Markers in Rectal Cancer
View article: Figure S1 from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma
Figure S1 from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma Open
Trial Schema
View article: Data from Epigenetic Markers in Rectal Cancer
Data from Epigenetic Markers in Rectal Cancer Open
DNA methylation changes in rectal cancer may serve as a new screening marker and a tool for monitoring recurrence. Importantly, these changes may also function as a predictive marker to allow appropriate exclusion of (neo)adjuvant therapie…
View article: Figure S1 from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma
Figure S1 from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma Open
Trial Schema
View article: Related Article from Epigenetic Markers in Rectal Cancer
Related Article from Epigenetic Markers in Rectal Cancer Open
Related Article from Epigenetic Markers in Rectal Cancer
View article: Figure S2 from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma
Figure S2 from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma Open
Analyses of additional immune subsets
View article: Data from Epigenetic Markers in Rectal Cancer
Data from Epigenetic Markers in Rectal Cancer Open
DNA methylation changes in rectal cancer may serve as a new screening marker and a tool for monitoring recurrence. Importantly, these changes may also function as a predictive marker to allow appropriate exclusion of (neo)adjuvant therapie…
View article: Data from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma
Data from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma Open
Purpose:In this prospective trial, we sought to assess the feasibility of concurrent administration of ipilimumab and radiation as adjuvant, neoadjuvant, or definitive therapy in patients with regionally advanced melanoma.Patients and Meth…
View article: Figure S2 from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma
Figure S2 from Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma Open
Analyses of additional immune subsets
View article: Comparing Outcomes of Oligometastases Treated with Hypofractionated Image-Guided Radiotherapy (HIGRT) with a Simultaneous Integrated Boost (SIB) Technique versus Metastasis Alone: A Multi-Institutional Analysis
Comparing Outcomes of Oligometastases Treated with Hypofractionated Image-Guided Radiotherapy (HIGRT) with a Simultaneous Integrated Boost (SIB) Technique versus Metastasis Alone: A Multi-Institutional Analysis Open
Purpose: We previously reported on the clinical outcomes of treating oligometastases with radiation using an elective simultaneous integrated boost technique (SIB), delivering higher doses to known metastases and reduced doses to adjacent …
View article: Corrigendum: Brain Metastases from Esophageal Squamous Cell Carcinoma: Clinical Characteristics and Prognosis
Corrigendum: Brain Metastases from Esophageal Squamous Cell Carcinoma: Clinical Characteristics and Prognosis Open
[This corrects the article DOI: 10.3389/fonc.2021.652509.].
View article: Transfer learning for fluence map prediction in adrenal stereotactic body radiation therapy
Transfer learning for fluence map prediction in adrenal stereotactic body radiation therapy Open
Objective: To design a deep transfer learning framework for modeling fluence map predictions for stereotactic body radiation therapy (SBRT) of adrenal cancer and similar sites that usually have a small number of cases. Approach: We develop…
View article: Brain Metastases from Esophageal Squamous Cell Carcinoma: Clinical Characteristics and Prognosis
Brain Metastases from Esophageal Squamous Cell Carcinoma: Clinical Characteristics and Prognosis Open
Purpose Due to the low incidence of intracranial disease among patients with esophageal cancer (EC), optimal management for these patients has not been established. The aim of this real-world study is to describe the clinical characteristi…
View article: Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology
Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology Open
Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients’ advanced disease at diagnosis. The NCCN Guidelines for Pancreatic Adenocarcino…
View article: Deep Learning–Based Fluence Map Prediction for Pancreas Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost
Deep Learning–Based Fluence Map Prediction for Pancreas Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost Open
The DL framework can effectively plan pancreas SBRT cases within 2 minutes. The predicted plans are clinically deliverable, with plan quality approaching that of manual planning.
View article: Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma
Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma Open
Purpose: In this prospective trial, we sought to assess the feasibility of concurrent administration of ipilimumab and radiation as adjuvant, neoadjuvant, or definitive therapy in patients with regionally advanced melanoma. Patients and Me…
View article: An interpretable planning bot for pancreas stereotactic body radiation therapy
An interpretable planning bot for pancreas stereotactic body radiation therapy Open
Pancreas stereotactic body radiotherapy treatment planning requires planners to make sequential, time consuming interactions with the treatment planning system (TPS) to reach the optimal dose distribution. We seek to develop a reinforcemen…
View article: Fluence Map Prediction Using Deep Learning Models – Direct Plan Generation for Pancreas Stereotactic Body Radiation Therapy
Fluence Map Prediction Using Deep Learning Models – Direct Plan Generation for Pancreas Stereotactic Body Radiation Therapy Open
Purpose: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a difficult and time-consuming task. In this study, we aim to develop a novel deep learning framework to generate clinical-quality plans by direct predi…
View article: Evaluating treatment protocols for rectal squamous cell carcinomas: the Duke experience and literature
Evaluating treatment protocols for rectal squamous cell carcinomas: the Duke experience and literature Open
Although the review of our institutional experience is limited by small numbers, our analysis suggests that definitive chemoradiation therapy is the preferred treatment approach to rectal SCC based on improved disease-related outcomes, sph…
View article: Multi-Institutional Analysis of Synchronous Prostate and Rectosigmoid Cancers
Multi-Institutional Analysis of Synchronous Prostate and Rectosigmoid Cancers Open
Purpose: To perform a multi-institutional analysis of patients with synchronous prostate and rectosigmoid cancers. Materials and Methods: A retrospective review of Duke University and Durham Veterans Affairs Medical Center records was perf…
View article: Do Higher Radiation Doses with Concurrent Chemotherapy in the Definitive Treatment of Esophageal Cancer Improve Outcomes? A Meta-Analysis and Systematic Review
Do Higher Radiation Doses with Concurrent Chemotherapy in the Definitive Treatment of Esophageal Cancer Improve Outcomes? A Meta-Analysis and Systematic Review Open
Background: To investigate the effects and safety profile of radiation dose escalation utilizing computerized tomography (CT) based radiotherapy techniques (including 3-Dimensional conformal radiotherapy, intensity-modulated radiotherapy a…