Brian G. Leroux
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View article: Treatment outcomes and short-term stability in adult anterior openbite patients treated with or without extractions: a National Dental Practice-Based Research Network study
Treatment outcomes and short-term stability in adult anterior openbite patients treated with or without extractions: a National Dental Practice-Based Research Network study Open
Objectives To investigate whether extractions in adult anterior openbite (AOB) patients lead to improved treatment outcomes and better short-term stability. Materials and Methods Records of extraction (EXT) and nonextraction (NE) adult pat…
View article: A single-centre, double-blind, randomized, placebo-controlled, 2-arm study to evaluate the safety and efficacy of once-weekly Sirolimus (Rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program.
A single-centre, double-blind, randomized, placebo-controlled, 2-arm study to evaluate the safety and efficacy of once-weekly Sirolimus (Rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program. Open
Background Aging leads to a decline in muscle mass and strength, contributing to frailty and decreased quality of life. Sirolimus (Rapamycin), an mTOR inhibitor, has shown potential in preclinical studies to extend lifespan and improve hea…
View article: Book-Sharing for Toddlers with Clefts (BOOST): Protocol for a randomized controlled trial of a remote intervention to promote language development in children with cleft palate
Book-Sharing for Toddlers with Clefts (BOOST): Protocol for a randomized controlled trial of a remote intervention to promote language development in children with cleft palate Open
Background Children with cleft palate, with or without cleft lip (CP±L), exhibit language delays on average compared to children without clefts. Interventions to address these disparities are scarce. In this multi-center study, Book Sharin…
View article: Bag-Valve-Mask Ventilation and Survival From Out-of-Hospital Cardiac Arrest: A Multicenter Study
Bag-Valve-Mask Ventilation and Survival From Out-of-Hospital Cardiac Arrest: A Multicenter Study Open
BACKGROUND: Few studies have measured ventilation during early cardiopulmonary resuscitation (CPR) before advanced airway placement. Resuscitation guidelines recommend pauses after every 30 chest compressions to deliver ventilations. The e…
View article: Localized microbially induced inflammation influences distant healthy tissues in the human oral cavity
Localized microbially induced inflammation influences distant healthy tissues in the human oral cavity Open
Variation in human immune response to the same bacterial or viral pathogen is well established in the literature. Variation in immune response to microbial challenge has also been observed within the human oral cavity. Our recent study foc…
View article: Observations by Caregivers Using the Infant with Clefts Observation Outcomes Instrument (iCOO): A Comparison of Three Versus Seven-day Daily Diaries
Observations by Caregivers Using the Infant with Clefts Observation Outcomes Instrument (iCOO): A Comparison of Three Versus Seven-day Daily Diaries Open
Objective Our goal was to compare data collected from 3- and 7-day Infant with Clefts Observation Outcomes (iCOO) diaries. Design Secondary data analysis of an observational longitudinal cohort study. Caregivers completed the daily iCOO fo…
View article: Local Anesthetic Efficacy in Marijuana Users and Nonusers: A Pilot Study
Local Anesthetic Efficacy in Marijuana Users and Nonusers: A Pilot Study Open
Objective: Despite the common clinical impression that patients with a history of drug use are challenging to anesthetize with local anesthesia, literature on this clinical phenomenon is sparse. The objective of this pilot study was to ass…
View article: Use of Video Directly Observed Therapy and Characteristics Associated With Use Among Patients Treated With Buprenorphine in an Office-based Setting
Use of Video Directly Observed Therapy and Characteristics Associated With Use Among Patients Treated With Buprenorphine in an Office-based Setting Open
Objectives Video directly observed therapy (video DOT) is a tool for confirming buprenorphine adherence that could complement the use of urine toxicology; research is needed to characterize the patients who are receptive and able to use th…
View article: Caregiver Observations of Infant Well-Being Before and After Cleft Lip Surgery
Caregiver Observations of Infant Well-Being Before and After Cleft Lip Surgery Open
Objective To evaluate the sensitivity to change of daily ratings of the comfort (COMF) and behavioral/emotional health (BEH) domains of the Infants with Clefts Observation Outcomes Instrument (iCOO) at 3 time points, and to assess the asso…
View article: Development and Testing of an Interpretational Bias Measure of Dental Anxiety
Development and Testing of an Interpretational Bias Measure of Dental Anxiety Open
Objectives We hypothesized that individuals with dental care-related anxiety and fear would interpret ambiguous dental situations more negatively than non-anxious individuals. The objectives of these studies were to develop and test a Meas…
View article: Exploration of Caregiver Interrater Agreement and Test-Retest Reliability on the Infant Cleft Observer Outcomes (iCOO)
Exploration of Caregiver Interrater Agreement and Test-Retest Reliability on the Infant Cleft Observer Outcomes (iCOO) Open
Caregiver and observer-reported measures are frequently used as outcomes for research on infants and young children who are unable to report on their own health. Our team developed the Infant with Clefts Observation Outcomes Instrument (iC…
View article: Anterior openbite malocclusion in adults:
Anterior openbite malocclusion in adults: Open
Objectives To investigate stability and satisfaction in adult anterior open bite (AOB) patients at least 9 months post-treatment, as well as patient and practitioner factors that may be associated with stability and satisfaction. Materials…
View article: Infant with Clefts Observation Outcomes Instrument (iCOO): A New Outcome for Infants and Young Children with Orofacial Clefts
Infant with Clefts Observation Outcomes Instrument (iCOO): A New Outcome for Infants and Young Children with Orofacial Clefts Open
Objective We evaluated the measurement properties for item and domain scores of the Infant with Clefts Observation Outcomes Instrument (iCOO). Design Cross-sectional (before lip surgery) and longitudinal study (preoperative baseline and 2 …
View article: Human variation in gingival inflammation
Human variation in gingival inflammation Open
Significance Experimental gingivitis studies where dental hygiene is withheld from select teeth, allowing natural bacterial accumulation, provide a unique opportunity to study the reversible transition from health to inflammatory disease i…
View article: Association of Intra-arrest Transport vs Continued On-Scene Resuscitation With Survival to Hospital Discharge Among Patients With Out-of-Hospital Cardiac Arrest
Association of Intra-arrest Transport vs Continued On-Scene Resuscitation With Survival to Hospital Discharge Among Patients With Out-of-Hospital Cardiac Arrest Open
Among patients experiencing out-of-hospital cardiac arrest, intra-arrest transport to hospital compared with continued on-scene resuscitation was associated with lower probability of survival to hospital discharge. Study findings are limit…
View article: A Prospective Cohort Study of Bisphenol A Exposure from Dental Treatment
A Prospective Cohort Study of Bisphenol A Exposure from Dental Treatment Open
Laboratory studies show that bisphenol A (BPA) leaches from bisphenol A-glycidyl methacrylate (bisGMA)-based dental materials. We aimed to quantify the extent to which children are exposed to BPA from dental treatment with bisGMA materials…
View article: Prediction of school-age IQ, academic achievement, and motor skills in children with positional plagiocephaly
Prediction of school-age IQ, academic achievement, and motor skills in children with positional plagiocephaly Open
Introduction Children with positional plagiocephaly and/or brachycephaly (PPB) are at risk of early developmental delay, but little is known about early life factors associated with school-age neurodevelopment. This study examined associat…
View article: Survival After Intravenous Versus Intraosseous Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Shock-Refractory Cardiac Arrest
Survival After Intravenous Versus Intraosseous Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Shock-Refractory Cardiac Arrest Open
Background: Antiarrhythmic drugs have not proven to significantly improve overall survival after out-of-hospital cardiac arrest from shock-refractory ventricular fibrillation/pulseless ventricular tachycardia. How this might be influenced …
View article: DS_10.1177_0022034520934725 – Supplemental material for A Prospective Cohort Study of Bisphenol A Exposure from Dental Treatment
DS_10.1177_0022034520934725 – Supplemental material for A Prospective Cohort Study of Bisphenol A Exposure from Dental Treatment Open
Supplemental material, DS_10.1177_0022034520934725 for A Prospective Cohort Study of Bisphenol A Exposure from Dental Treatment by C.M. McKinney, B.G. Leroux, A.L. Seminario, A. Kim, Z. Liu, S. Samy and S. Sathyanarayana in Journal of Dent…
View article: Oral health and plaque microbial profile in juvenile idiopathic arthritis
Oral health and plaque microbial profile in juvenile idiopathic arthritis Open
Background The oral microbiota has been implicated in the pathogenesis of rheumatoid arthritis through activation of mucosal immunity. This study tested for associations between oral health, microbial communities and juvenile idiopathic ar…