Brian A. Gordon
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View article: Remote assessments of sleep and cognition in cognitively normal older adults at risk for Alzheimer disease
Remote assessments of sleep and cognition in cognitively normal older adults at risk for Alzheimer disease Open
Remote, multi-day assessments of cognition and sleep revealed subtle non-linear associations between nightly sleep and next-day cognition in cognitively unimpaired older adults. Furthermore, the individualized nature of sleep-cognition rel…
View article: Reliability of longitudinal sleep monitoring in amyloid‐negative and amyloid‐positive older adults
Reliability of longitudinal sleep monitoring in amyloid‐negative and amyloid‐positive older adults Open
Background Sleep disturbances have been associated with both Alzheimer disease (AD) pathology and cognitive symptoms but there are few studies with longitudinal measures of sleep, AD biomarkers, and cognitive performance. To design and ade…
View article: Early Detection and Monitoring of Amyloid‐Related Imaging Abnormalities in Monoclonal Antibody Therapy Using Generalized Diffusion Basis Spectrum Imaging (g‐DBSI): A Pilot Study
Early Detection and Monitoring of Amyloid‐Related Imaging Abnormalities in Monoclonal Antibody Therapy Using Generalized Diffusion Basis Spectrum Imaging (g‐DBSI): A Pilot Study Open
Background Amyloid‐Related Imaging Abnormalities (ARIA), characterized by vasogenic edema or sulcal effusions (ARIA‐E) or hemorrhagic lesions (microhemorrhages, superficial siderosis, or, rarely, microhemorrhages) (ARIA‐H), remain a signif…
View article: Clinical application and reporting of neurofilament quantification in neuropsychiatric disorders: an international overview
Clinical application and reporting of neurofilament quantification in neuropsychiatric disorders: an international overview Open
Background The quantification of Neurofilament Light chain (NfL) in blood and cerebrospinal fluid (CSF) has proven valuable for diagnosing and prognosing various neurological disorders, including Alzheimer's disease, frontotemporal dementi…
View article: Impact of sex, age and glymphatic clearance on meningeal tau PET signal
Impact of sex, age and glymphatic clearance on meningeal tau PET signal Open
Background Variability in meningeal signal has been observed with various tau‐PET tracers. Differences have been observed in sex and age. Furthermore, the potential role of glymphatic clearance in this variability remains unclear. Here we …
View article: User‐friendly tools for tau PET harmonization in clinical trials: The Uniτ Ecosystem
User‐friendly tools for tau PET harmonization in clinical trials: The Uniτ Ecosystem Open
Background HEAD is a longitudinal, multi‐site, non‐randomized study aiming to harmonize different tau PET tracers onto a common scale for enrichment and monitoring of anti‐tau clinical trials. To achieve this, the Uniτ scale is being devel…
View article: High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer’s disease phenotypes in a large mixed-dementia cohort
High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer’s disease phenotypes in a large mixed-dementia cohort Open
Novel plasma assays enabled accurate blood-based biomarkers for neurodegenerative diseases with minimally invasive options for clinical use. Large-scale studies encompassing multiple neurodegenerative diseases using novel multiplex platfor…
View article: The Knight Alzheimer Research Imaging (KARI) dataset: a comprehensive multimodal resource for exploring aging, preclinical, and symptomatic Alzheimer disease pathology
The Knight Alzheimer Research Imaging (KARI) dataset: a comprehensive multimodal resource for exploring aging, preclinical, and symptomatic Alzheimer disease pathology Open
Alzheimer disease (AD) remains a significant global public health challenge, requiring robust multimodal datasets to elucidate its prolonged preclinical phase, improve early detection, advance understanding of disease trajectories, and gui…
View article: Quality of Evidence in European Stroke Organisation and American Heart Association Stroke Guidelines
Quality of Evidence in European Stroke Organisation and American Heart Association Stroke Guidelines Open
BACKGROUND: Evidence-based practice relies on clinical guidelines, whose recommendations depend on the quality, relevance, and validity of supporting research. We evaluated the class/strength and level of evidence (LOE) or quality of evide…
View article: Predicting future cognitive impairment in preclinical Alzheimer’s disease using multimodal imaging: a multisite machine learning study
Predicting future cognitive impairment in preclinical Alzheimer’s disease using multimodal imaging: a multisite machine learning study Open
Predicting the likelihood of developing Alzheimer’s disease (AD) dementia in at-risk individuals is important for the design of and optimal recruitment for clinical trials of disease-modifying therapies. Machine learning (ML) has been show…
View article: Reference proteins to improve Core 1 and Core 2 Alzheimer’s disease CSF and plasma biomarkers
Reference proteins to improve Core 1 and Core 2 Alzheimer’s disease CSF and plasma biomarkers Open
Concentration-based fluid biomarkers represent an informative and cost-effective way to detect and monitor Alzheimer’s disease (AD) pathology. However, non-AD-related inter-individual variation in biofluids can also affect biomarker concen…
View article: Remote Digital Cognitive Assessment in a Trial-Ready Alzheimer’s Cohort: A Scalable Approach for Early Intervention Studies
Remote Digital Cognitive Assessment in a Trial-Ready Alzheimer’s Cohort: A Scalable Approach for Early Intervention Studies Open
Background: Early detection of cognitive decline in Alzheimer’s disease (AD), particularly in preclinical stages, is critical for evaluating therapeutic interventions. Traditional cognitive assessments often lack reliability and require le…
View article: Variability of longitudinal sleep monitoring in amyloid‐negative and amyloid‐positive cognitively unimpaired and mildly impaired older adults
Variability of longitudinal sleep monitoring in amyloid‐negative and amyloid‐positive cognitively unimpaired and mildly impaired older adults Open
INTRODUCTION Sleep disturbances are associated with Alzheimer's disease (AD) pathology and cognitive symptoms, but few studies have longitudinally assessed sleep, AD biomarkers, and cognition. Understanding how sleep changes over time in o…
View article: Comparison of amyloid chronicity and EYO in autosomal dominant Alzheimer's disease
Comparison of amyloid chronicity and EYO in autosomal dominant Alzheimer's disease Open
INTRODUCTION Preclinical Alzheimer's disease (AD) can be described relative to biomarker positivity onset time. METHODS We estimated time from amyloid positivity (A+) using sampled iterative local approximation (SILA) in a longitudinal aut…
View article: The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology
The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology Open
BACKGROUND Tau‐derived cerebrospinal fluid (CSF) biomarkers correlate with amyloid‐beta (Aβ) plaques or tau tangles in Alzheimer's disease (AD). This study assessed the effects of long‐term anti‐Aβ antibodies on amyloid plaques, tau tangle…
View article: Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease Open
The link between regional tau load and clinical manifestation of Alzheimer’s disease (AD) highlights the importance of characterizing spatial tau distribution across disease variants. In typical (memory-predominant) AD, the spatial progres…
View article: Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN‐TU‐001 trial
Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN‐TU‐001 trial Open
INTRODUCTION Monoclonal anti‐amyloid therapies are now accessible, but how these treatments influence changes within the brain is still not clear. We investigated overall and regional change in amyloid removal, glucose metabolism, and atro…
View article: Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference
Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference Open
INTRODUCTION The Down syndrome‐associated Alzheimer's disease (DSAD) autosomal dominant Alzheimer's disease (ADAD) 2024 Conference in Barcelona, convened under an Alzheimer's Association International Society to Advance Alzheimer's Researc…
View article: A Failed Relationship or a Great Opportunity: Professional Runners' Experience with Sponsorships
A Failed Relationship or a Great Opportunity: Professional Runners' Experience with Sponsorships Open
The primary purpose of this study was to explore how professional runners form attitudes toward sponsors. The secondary purpose was to understand perceived relationships of professional runners with sponsors. This study was guided by the r…
View article: Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview
Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview Open
INTRODUCTION Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further cha…
View article: Ubiquitin–proteasome system in the different stages of dominantly inherited Alzheimer's disease
Ubiquitin–proteasome system in the different stages of dominantly inherited Alzheimer's disease Open
INTRODUCTION This study investigated the role of the ubiquitin–proteasome system (UPS) in dominantly inherited Alzheimer's disease (DIAD) by examining cerebrospinal fluid (CSF) levels of UPS proteins. METHOD The SOMAscan assay was used to …
View article: Analyzing heterogeneity in Alzheimer disease using multimodal normative modeling on imaging‐based ATN biomarkers
Analyzing heterogeneity in Alzheimer disease using multimodal normative modeling on imaging‐based ATN biomarkers Open
INTRODUCTION Previous studies have applied normative modeling on a single neuroimaging modality to investigate Alzheimer disease (AD) heterogeneity. We employed a deep learning‐based multimodal normative framework to analyze individual‐lev…
View article: Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease
Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease Open
Insoluble tau aggregates within neurofibrillary tangles are a defining neuropathological feature of Alzheimer's disease (AD) and closely correlate with clinical symptoms. Although tau pathology can be assessed using tau positron emission t…
View article: The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset
The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset Open
We present a comprehensive global analysis of genetic variants associated with autosomal-dominant Alzheimer’s disease (ADAD). A total of 550 variants in the APP, PSEN1 and PSEN2 genes were identified, of which 279 were classified as pathog…
View article: Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome
Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome Open
INTRODUCTION Alzheimer's disease (AD) in Down syndrome (DS) is associated with changes in brain structure. It is unknown if thickness and volumetric changes can identify AD stages and if they are similar to other genetic forms of AD. METHO…
View article: Erratum: Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer’s disease
Erratum: Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer’s disease Open
[This corrects the article DOI: 10.1162/netn_a_00395.].