Brian Harsch
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The effects of saturated fatty acid supplements on plasma and milk concentration of fatty acid esters of hydroxy fatty acids in dairy cows Open
Fatty acid esters of hydroxy fatty acids (FAHFA) are a novel class of bioactive lipids with demonstrated antidiabetic and anti-inflammatory properties in rodent models and humans but have not been investigated in cows. The major FAHFA are …
A Cell Autonomous Free fatty acid receptor 4 - ChemR23 Signaling Cascade Protects Cardiac Myocytes from Ischemic Injury Open
Acute myocardial infarction (AMI) causes ischemic damage and cardiac remodeling that ultimately progresses into ischemic cardiomyopathy (ICM). Coronary revascularization reduces morbidity and mortality from an MI, however, reperfusion also…
Ffar4 regulates inflammatory oxylipin balance in the brain Open
Background Oxylipins are oxygenated fatty acid (FA) metabolites that are important mediators of inflammation. Neuroinflammation is a hallmark of Alzheimer’s disease (AD), and brains of AD patients contain more pro‐inflammatory and less ant…
ABCA1 and apoA-I dependent 12-hydroxyeicosatetraenoic acid efflux regulates macrophage inflammatory signaling Open
Aberrant high-density lipoprotein (HDL) function is implicated in inflammation-associated pathologies. While HDL ABCA1-mediated reverse cholesterol and phospholipid transport are well described, the movement of pro-/anti-inflammatory lipid…
Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders Open
Lipoprotein metabolism is critical to inflammation. While the periphery and central nervous system (CNS) have separate yet connected lipoprotein systems, impaired lipoprotein metabolism is implicated in both cardiometabolic and neurologica…
Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease Open
A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyuns…
Free fatty acid receptor 4 (FFAR4) regulates cardiac oxylipin balance to promote inflammation resolution in a model of heart failure preserved ejection fraction secondary to metabolic syndrome Open
Free fatty acid receptor 4 (Ffar4) is a G-protein coupled receptor for long-chain fatty acids that improves metabolism and attenuates inflammation. Heart failure preserved ejection fraction (HFpEF) is a complex clinical syndrome, but a pre…
View article: Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload
Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload Open
Aims Free fatty acid receptor 4 (Ffar4) is a G-protein-coupled receptor for endogenous medium-/long-chain fatty acids that attenuates metabolic disease and inflammation. However, the function of Ffar4 in the heart is unclear. Given its put…
View article: Free fatty acid receptor 4 is a nutrient sensor that resolves inflammation to maintain cardiac homeostasis
Free fatty acid receptor 4 is a nutrient sensor that resolves inflammation to maintain cardiac homeostasis Open
Background Non-resolving activation of immune responses is central to the pathogenesis of heart failure (HF). Free fatty acid receptor 4 (Ffar4) is a G-protein coupled receptor (GPR) for medium-and long-chain fatty acids (FA) that regulat…
Subcellular compartmentalization of proximal Gαq-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes Open
G protein-coupled receptors that signal through Gαq (Gq receptors), such as α1-adrenergic receptors (α1-ARs) or angiotensin receptors, share a common proximal signaling pathway that activates phospholipase Cβ1 (PLCβ1), which cleaves phosph…