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View article: Paracrine iron activates Hopx+ rectal cancer stem cells to display radioresistance
Paracrine iron activates Hopx+ rectal cancer stem cells to display radioresistance Open
Collectively, quiescent cancer stem cells could establish a new dependency on anti-apoptotic programs in their dying neighbors. This study highlights targeting and regulating Hopx+ quiescent stem cells could be a promising therapeutic appr…
View article: Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma
Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma Open
Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer‐related deaths worldwide. Despite advancements in antiviral therapies for hepatitis B (HBV) and hepatitis C (HCV), HCC inci…
View article: Impact of iron deficiency on therapeutic outcomes in colorectal cancer patients: a single-center cohort study
Impact of iron deficiency on therapeutic outcomes in colorectal cancer patients: a single-center cohort study Open
ID is closely associated with aggressive tumor biology, suboptimal response to neoadjuvant therapy, and impaired postoperative recovery. Dysregulation of iron homeostasis and ferroptosis pathways in ID patients may contribute to CRC progre…
View article: Global bone cancer incidence and death rate analysis at 40 years
Global bone cancer incidence and death rate analysis at 40 years Open
Bone cancer incidence and mortality are heavily influenced by healthcare system capacity and socioeconomic factors.
View article: Genetic determinants of micronutrient levels and their causal impact on osteonecrosis of the femoral head: A 2-sample Mendelian randomization study
Genetic determinants of micronutrient levels and their causal impact on osteonecrosis of the femoral head: A 2-sample Mendelian randomization study Open
Osteonecrosis of the femoral head (ONFH) is a debilitating condition with unclear pathophysiology. Micronutrients are implicated in bone health, but their causal relationship with ONFH remains uncertain. This study aims to investigate the …
View article: Gefitinib Facilitates Bone Fracture Healing <i>via</i> Inhibition of the EGFR Pathway and Counteracting SOX9-driven Bone Metabolic Reprogramming
Gefitinib Facilitates Bone Fracture Healing <i>via</i> Inhibition of the EGFR Pathway and Counteracting SOX9-driven Bone Metabolic Reprogramming Open
Gefitinib enhances bone fracture healing by modulating lipid metabolism through SOX9, suggesting its potential as a therapeutic agent for improving fracture outcomes.
View article: A Facile Strategy to Restore the Optic Nerve Functionality Using an Injectable Conducting Hydrogel
A Facile Strategy to Restore the Optic Nerve Functionality Using an Injectable Conducting Hydrogel Open
This study introduces a novel injectable conductive polymer hydrogel from poly(3,4‐ethylenedioxythiophene) (PEDOT). This hydrogel is designed to facilitate the recovery of electrophysiological function in injured optic nerves. The hydrogel…
View article: The impact of the new WHO classification of renal cell carcinoma on the diagnosis of hereditary leiomyomatosis and renal cell carcinoma
The impact of the new WHO classification of renal cell carcinoma on the diagnosis of hereditary leiomyomatosis and renal cell carcinoma Open
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is caused by heterozygous germline variants in the fumarate hydratase (FH) gene. Inheritance follows an autosomal dominant pattern. Loss of FH confers a predisposition for…
View article: The Value of Infrapyloric Lymph Nodes Dissection in Right Hemicolectomy for Hepatic Flexure Colon Cancer: A Multicenter Analysis Based on Propensity Score Matching
The Value of Infrapyloric Lymph Nodes Dissection in Right Hemicolectomy for Hepatic Flexure Colon Cancer: A Multicenter Analysis Based on Propensity Score Matching Open
BACKGROUND: There is a dispute regarding the necessity of infrapyloric lymph node dissection in right hemicolectomy for hepatic flexure colon cancer. OBJECTIVE: To evaluate the risk factors for infrapyloric lymph node metastasis and the pr…
View article: Influence of the ligation sequence of the inferior mesenteric artery and vein on circulating tumor cells in laparoscopic rectal cancer surgery: a prospective pilot study
Influence of the ligation sequence of the inferior mesenteric artery and vein on circulating tumor cells in laparoscopic rectal cancer surgery: a prospective pilot study Open
Both A-first and V-first ligation sequences are viable and safe options in laparoscopic rectal cancer surgery. The V-first approach may be more effective in reducing levels of CTCs in peripheral blood. Further randomized studies are warran…
View article: Regulation of PI3K signaling in cancer metabolism and PI3K-targeting therapy
Regulation of PI3K signaling in cancer metabolism and PI3K-targeting therapy Open
The phosphatidylinositol-3-kinase (PI3K) signaling plays a key role in various cellular functions and is frequently activated in cancer, making it an attractive therapeutic target. The PI3K signaling pathway influencing glucose metabolism,…
View article: Noninvasive multi-cancer detection using blood-based cell-free microRNAs
Noninvasive multi-cancer detection using blood-based cell-free microRNAs Open
Patients diagnosed with early-stage cancers have a substantially higher chance of survival than those with late-stage diseases. However, the option for early cancer screening is limited, with most cancer types lacking an effective screenin…
View article: Pathological response following neoadjuvant immunotherapy and imaging characteristics in dMMR/MSI-H locally advanced colorectal cancer
Pathological response following neoadjuvant immunotherapy and imaging characteristics in dMMR/MSI-H locally advanced colorectal cancer Open
Background In recent years, there has been significant research interest in immunotherapy for colorectal cancer (CRC). Specifically, immunotherapy has emerged as the primary treatment for patients with mismatch repair gene defects (dMMR) o…
View article: Cytokine levels in breast cancer are highly dependent on cytomegalovirus (CMV) status
Cytokine levels in breast cancer are highly dependent on cytomegalovirus (CMV) status Open
Purpose Breast cancer accounts for 30% of all female cancers in the US. Cytomegalovirus (CMV), a herpesvirus that establishes lifelong infection, may play a role in breast cancer. CMV is not oncogenic, yet viral DNA and proteins have been …
View article: Proteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection
Proteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection Open
Background Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women globally. Despite advances, there is considerable variation in clinical outcomes for patients with non-luminal A tumors, …
View article: The BTB-ZF gene Bm-mamo regulates pigmentation in silkworm caterpillars
The BTB-ZF gene Bm-mamo regulates pigmentation in silkworm caterpillars Open
The color pattern of insects is one of the most diverse adaptive evolutionary phenotypes. However, the molecular regulation of this color pattern is not fully understood. In this study, we found that the transcription factor Bm-mamo is res…
View article: Mapping and characterization of structural variation in 17,795 human genomes
Mapping and characterization of structural variation in 17,795 human genomes Open
A key goal of whole-genome sequencing for studies of human genetics is to interrogate all forms of variation, including single-nucleotide variants, small insertion or deletion (indel) variants and structural variants. However, tools and re…
View article: Association of clinicopathologic and molecular factors with the occurrence of positive margins in breast cancer
Association of clinicopathologic and molecular factors with the occurrence of positive margins in breast cancer Open
Purpose To explore the association of clinicopathologic and molecular factors with the occurrence of positive margins after first surgery in breast cancer. Methods The clinical and RNA-Seq data for 951 (75 positive and 876 negative margins…
View article: The Significance of Combined Detection of Ultrasonography, Pediatric Appendicitis Score and C-reactive Protein in the Diagnosis and Pathological type of Acute Appendicitis in Children
The Significance of Combined Detection of Ultrasonography, Pediatric Appendicitis Score and C-reactive Protein in the Diagnosis and Pathological type of Acute Appendicitis in Children Open
Background : As one of the most common diseases of acute abdomen, early diagnosis of acute appendicitis remains a vital issue. This study aims to explore the value of combined ultrasonography, Pediatric Appendicitis Score and C-reactive pr…
View article: Efficacy and safety of anlotinib plus XELOX regimen as first-line therapy for mCRC: a single-arm, multicenter, phase II study (ALTER-C-001)
Efficacy and safety of anlotinib plus XELOX regimen as first-line therapy for mCRC: a single-arm, multicenter, phase II study (ALTER-C-001) Open
Background Anlotinib showed encouraging anti-tumor activity in metastatic colorectal cancer (mCRC). This study was designed to assess the efficacy and safety of anlotinib plus XELOX as first-line therapy in mCRC patients. Materials and Met…
View article: High-efficiency gene editing in<i>Anopheles sinensis</i>using ReMOT control
High-efficiency gene editing in<i>Anopheles sinensis</i>using ReMOT control Open
CRISPR/Cas9-mediated gene editing provides an effective method for deciphering the molecular mechanisms underlying mosquito development and mosquito-borne disease transmission, as well as for exploring genetic control strategies. However, …
View article: Simultaneous Imaging and Photodynamic‐Enhanced Photothermal Inhibition of Cancer Cells Using a Multifunctional System Combining Indocyanine Green and Polydopamine‐Preloaded Upconversion Luminescent Nanoparticles
Simultaneous Imaging and Photodynamic‐Enhanced Photothermal Inhibition of Cancer Cells Using a Multifunctional System Combining Indocyanine Green and Polydopamine‐Preloaded Upconversion Luminescent Nanoparticles Open
This work introduces a novel multifunctional system called UPIPF (upconversion‐polydopamine‐indocyanine‐polyethylene‐folic) for upconversion luminescent (UCL) imaging of cancer cells using near‐infrared (NIR) illumination. The system demon…
View article: High-intensity interval training improves fatty infiltration in the rotator cuff through the β3 adrenergic receptor in mice
High-intensity interval training improves fatty infiltration in the rotator cuff through the β3 adrenergic receptor in mice Open
Aims Rotator cuff muscle atrophy and fatty infiltration affect the clinical outcomes of rotator cuff tear patients. However, there is no effective treatment for fatty infiltration at this time. High-intensity interval training (HIIT) helps…
View article: Selection of optimal quantile protein biomarkers based on cell-level immunohistochemistry data
Selection of optimal quantile protein biomarkers based on cell-level immunohistochemistry data Open
Background Protein biomarkers of cancer progression and response to therapy are increasingly important for improving personalized medicine. Advanced quantitative pathology platforms enable measurement of protein expression in tissues at th…