Brian J. Caldwell
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View article: The Work Environment of the School Leader in Australia: The Case for Sustained Change in Role and Practice
The Work Environment of the School Leader in Australia: The Case for Sustained Change in Role and Practice Open
The questions addressed in this essay are (1) how has the work environment of school leaders changed in the early years of the 21st century, (2) how have these changes affected the role of the school leader, (3) what is the association bet…
View article: Parent-Reported Experience With Pediatric Urology Telemedicine Visits During the COVID-19 Pandemic
Parent-Reported Experience With Pediatric Urology Telemedicine Visits During the COVID-19 Pandemic Open
Introduction Telemedicine has had a slow integration into surgical subspecialties like urology. Little data exists on its effect on urologic patient-provider rapport nor long term clinical outcomes. The purpose of this study was to assess …
View article: Structure of a Rad52 homolog from bacteriophage in complex with a novel duplex intermediate of DNA annealing
Structure of a Rad52 homolog from bacteriophage in complex with a novel duplex intermediate of DNA annealing Open
Human Rad52 protein binds to ssDNA and promotes the annealing of complementary strands. This activity is central to multiple DNA repair pathways and Rad52 is a target for cancer therapeutics. Previous crystal structures of the DNA binding …
View article: Mutational Analysis of Redβ Single Strand Annealing Protein: Roles of the 14 Lysine Residues in DNA Binding and Recombination In Vivo
Mutational Analysis of Redβ Single Strand Annealing Protein: Roles of the 14 Lysine Residues in DNA Binding and Recombination In Vivo Open
Redβ is a 261 amino acid protein from bacteriophage λ that promotes a single-strand annealing (SSA) reaction for repair of double-stranded DNA (dsDNA) breaks. While there is currently no high-resolution structure available for Redβ, models…
View article: Oligomeric complexes formed by Redβ single strand annealing protein in its different DNA bound states
Oligomeric complexes formed by Redβ single strand annealing protein in its different DNA bound states Open
Redβ is a single strand annealing protein from bacteriophage λ that binds loosely to ssDNA, not at all to pre-formed dsDNA, but tightly to a duplex intermediate of annealing. As viewed by electron microscopy, Redβ forms oligomeric rings on…
View article: Crystal structure of the Redβ C-terminal domain in complex with λ Exonuclease reveals an unexpected homology with λ Orf and an interaction with Escherichia coli single stranded DNA binding protein.
Crystal structure of the Redβ C-terminal domain in complex with λ Exonuclease reveals an unexpected homology with λ Orf and an interaction with Escherichia coli single stranded DNA binding protein. Open
Bacteriophage λ encodes a DNA recombination system that includes a 5'-3' exonuclease (λ Exo) and a single strand annealing protein (Redβ). The two proteins form a complex that is thought to mediate loading of Redβ directly onto the single-…
View article: Crystal structure of the Redβ C-terminal domain in complex with λ Exonuclease reveals an unexpected homology with λ Orf and an interaction with<i>Escherichia coli</i>single stranded DNA binding protein
Crystal structure of the Redβ C-terminal domain in complex with λ Exonuclease reveals an unexpected homology with λ Orf and an interaction with<i>Escherichia coli</i>single stranded DNA binding protein Open
Bacteriophage λ encodes a DNA recombination system that includes a 5'-3' exonuclease (λ Exo) and a single strand annealing protein (Redβ). The two proteins form a complex that is thought to mediate loading of Redβ directly onto the single-…
View article: School Leadership and Professional Autonomy
School Leadership and Professional Autonomy Open
School autonomy remains an elusive term in research, policy and practice as does the role of the leader under its various manifestations. The purpose of this article is to illuminate the issues and describe new perspectives and important b…
View article: Leadership that transforms schools and school systems
Leadership that transforms schools and school systems Open
This paper will report on the findings of four international research projects on leadership in high-performing school systems around the world. The paper will focus on building the capacity of school leaders to exercise professional auton…