Brian J. Curtis
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View article: Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A
Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A Open
Diversification of structurally complex natural products remains a key challenge in the discovery of next-generation therapeutics. Premarineosin A, a potent and selective antimalarial natural product, is a promising yet underexplored scaff…
View article: Structural Diversification of 14-Membered Macrolides by Chemoenzymatic Synthesis
Structural Diversification of 14-Membered Macrolides by Chemoenzymatic Synthesis Open
The pikromycin polyketide synthase (PKS) catalyzes formation of 12-membered macrolactone 10-deoxymethynolide, and 14-membered macrolactone narbonolide. Herein, we show the efficient diversification of novel 14-membered macrolactones from a…
View article: Structural Diversification of 14-Membered Macrolides by Chemoenzymatic Synthesis
Structural Diversification of 14-Membered Macrolides by Chemoenzymatic Synthesis Open
The pikromycin polyketide synthase (PKS) catalyzes formation of 12-membered macrolactone 10-deoxymethynolide, and 14-membered macrolactone narbonolide. Herein, we show the efficient diversification of novel 14-membered macrolactones from a…
View article: Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A
Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A Open
Diversification of structurally complex natural products remains a key challenge in the discovery of next-generation therapeutics. Premarineosin A, a potent and selective antimalarial natural product, is a promising yet underexplored scaff…
View article: Engineering a Biosynthetic Pathway for the Production of (+)-Brevianamides A and B in Escherichia coli
Engineering a Biosynthetic Pathway for the Production of (+)-Brevianamides A and B in Escherichia coli Open
The privileged fused-ring system comprising the bicyclo[2.2.2]diazaoctane (BDO) core is prevalent in diketopiperazine (DKP) natural products with potent and diverse biological activities, with some being explored as drug candidates. Typica…
View article: Publisher Correction: Host–microbe interactions rewire metabolism in a C. elegans model of leucine breakdown deficiency
Publisher Correction: Host–microbe interactions rewire metabolism in a C. elegans model of leucine breakdown deficiency Open
View article: Host–microbe interactions rewire metabolism in a C. elegans model of leucine breakdown deficiency
Host–microbe interactions rewire metabolism in a C. elegans model of leucine breakdown deficiency Open
View article: Author Correction: Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans
Author Correction: Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans Open
View article: <i>N</i>-to-<i>S</i> Acyl Transfer as an Enabling Strategy in Asymmetric and Chemoenzymatic Synthesis
<i>N</i>-to-<i>S</i> Acyl Transfer as an Enabling Strategy in Asymmetric and Chemoenzymatic Synthesis Open
The observation of thioester-mediated acyl transfer processes in nature has inspired the development of novel protein synthesis and functionalization methodologies. The chemoselective transfer of an acyl group from S-to-N is …
View article: Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans
Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans Open
Fatty acid desaturation is central to metazoan lipid metabolism and provides building blocks of membrane lipids and precursors of diverse signaling molecules. Nutritional conditions and associated microbiota regulate desaturase expression,…
View article: Evolutionarily related host and microbial pathways regulate fat desaturation
Evolutionarily related host and microbial pathways regulate fat desaturation Open
Fatty acid desaturation is central to metazoan lipid metabolism and provides building blocks of membrane lipids and precursors of diverse signaling molecules. Nutritional conditions and associated microbiota regulate desaturase expression …
View article: Oligonucleotide Catabolism-Derived Gluconucleosides in <i>Caenorhabditis elegans</i>
Oligonucleotide Catabolism-Derived Gluconucleosides in <i>Caenorhabditis elegans</i> Open
Nucleosides are essential cornerstones of life, and nucleoside derivatives and synthetic analogues have important biomedical applications. Correspondingly, production of non-canonical nucleoside derivatives in animal model systems is of pa…
View article: Sex-specificity of the C. elegans metabolome
Sex-specificity of the C. elegans metabolome Open
View article: Publisher Correction: Parallel pathways for serotonin biosynthesis and metabolism in C. elegans
Publisher Correction: Parallel pathways for serotonin biosynthesis and metabolism in C. elegans Open
View article: Parallel pathways for serotonin biosynthesis and metabolism in C. elegans
Parallel pathways for serotonin biosynthesis and metabolism in C. elegans Open
View article: Sex-specificity of the <i>C. elegans</i> metabolome
Sex-specificity of the <i>C. elegans</i> metabolome Open
Recent studies of animal metabolism have revealed large numbers of novel metabolites that are involved in all aspects of organismal biology, but it is unclear to what extent metabolomes differ between sexes. Here, using untargeted comparat…
View article: C. elegans as a model for inter-individual variation in metabolism
C. elegans as a model for inter-individual variation in metabolism Open
View article: Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates <i>C. elegans</i> Starvation Survival
Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates <i>C. elegans</i> Starvation Survival Open
The recently discovered modular glucosides (MOGLs) form a large metabolite library derived from combinatorial assembly of moieties from amino acid, neurotransmitter, and lipid metabolism in the model organism C. elegans
View article: Syntheses of Amorfrutins and Derivatives via Tandem Diels–Alder and Anionic Cascade Approaches
Syntheses of Amorfrutins and Derivatives via Tandem Diels–Alder and Anionic Cascade Approaches Open
We describe two complementary approaches based on a convergent [4+2] logic toward the synthesis of amorfrutins, cannabinoids, and related plant metabolites. An anionic cascade cyclization employing β-methoxycrotonates and β-chloro-α,β-unsa…
View article: An Untargeted Approach for Revealing Electrophilic Metabolites
An Untargeted Approach for Revealing Electrophilic Metabolites Open
Reactive electrophilic intermediates such as coenzyme A esters play central roles in metabolism but are difficult to detect with conventional strategies. Here, we introduce hydroxylamine-based stable isotope labeling to convert reactive el…
View article: Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles
Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles Open
Signaling molecules derived from attachment of diverse metabolic building blocks to ascarosides play a central role in the life history of C. elegans and other nematodes; however, many aspects of their biogenesis remain unclear. Using comp…
View article: Author response: Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles
Author response: Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Signaling molecules derived fro…
View article: CCDC 2020283: Experimental Crystal Structure Determination
CCDC 2020283: Experimental Crystal Structure Determination Open
View article: Identification of Uric Acid Gluconucleoside–Ascaroside Conjugates in <i>Caenorhabditis elegans</i> by Combining Synthesis and MicroED
Identification of Uric Acid Gluconucleoside–Ascaroside Conjugates in <i>Caenorhabditis elegans</i> by Combining Synthesis and MicroED Open
Few nucleoside-derived natural products have been identified from animals, despite the ubiquity of nucleosides in living organisms. Here, we use a combination of synthesis and the emerging electron microscopy technique microcrystal electro…