Brian J. Leyshon
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View article: Glycerophosphocholine and Betaine Improve Markers of Neuronal Development
Glycerophosphocholine and Betaine Improve Markers of Neuronal Development Open
View article: Effects of new lipid ingredients during pregnancy and lactation on rat offspring brain gene expression
Effects of new lipid ingredients during pregnancy and lactation on rat offspring brain gene expression Open
Maternal dietary fat intake during pregnancy and lactation may influence the bioavailability of essential lipophilic nutrients, such as docosahexaenoic acid (DHA), that are important for both the mother and her child's development.
View article: A hydrolyzed lipid blend diet promotes myelination in neonatal piglets in a region and concentration‐dependent manner
A hydrolyzed lipid blend diet promotes myelination in neonatal piglets in a region and concentration‐dependent manner Open
The impact of early life nutrition on myelin development is of interest given that cognitive and behavioral function depends on proper myelination. Evidence shows that myelination can be altered by dietary lipid, but most of these studies …
View article: P07-034-23 A Novel Mono- and Diglyceride Emulsion Improves DHA Absorption
P07-034-23 A Novel Mono- and Diglyceride Emulsion Improves DHA Absorption Open
View article: P27-009-23 Impact of Cardiovascular Biomarkers on Dementia
P27-009-23 Impact of Cardiovascular Biomarkers on Dementia Open
elderly overweight participants with cardiovascular risk factors and self-reported memory complaints.Methods: We conducted a 12-week, randomized, controlled study to explore the effects of eating 42-56 g/d of peanuts (PG) in comparison to …
View article: Automated identification of piglet brain tissue from MRI images using Region-based Convolutional Neural Networks
Automated identification of piglet brain tissue from MRI images using Region-based Convolutional Neural Networks Open
Magnetic resonance imaging is an important tool for characterizing volumetric changes of the piglet brain during development. Typically, an early step of an imaging analysis pipeline is brain extraction, or skull stripping. Brain extractio…
View article: A Role for Data Science in Precision Nutrition and Early Brain Development
A Role for Data Science in Precision Nutrition and Early Brain Development Open
Multimodal brain magnetic resonance imaging (MRI) can provide biomarkers of early influences on neurodevelopment such as nutrition, environmental and genetic factors. As the exposure to early influences can be separated from neurodevelopme…
View article: Automated identification of piglet brain tissue from MRI images using Region-based Convolutional Neural Networks
Automated identification of piglet brain tissue from MRI images using Region-based Convolutional Neural Networks Open
Magnetic Resonance Imaging is an important tool for characterizing volumetric changes of the piglet brain during development. Typically, an early step of an imaging analysis pipeline is brain extraction, or skull stripping. Brain extractio…
View article: Hydrolyzed Fat Formula Increases Brain White Matter in Small for Gestational Age and Appropriate for Gestational Age Neonatal Piglets
Hydrolyzed Fat Formula Increases Brain White Matter in Small for Gestational Age and Appropriate for Gestational Age Neonatal Piglets Open
Background: Intrauterine growth restriction is a common cause of small for gestational age (SGA) infants worldwide. SGA infants are deficient in digestive enzymes required for fat digestion and absorption compared to appropriate for…
View article: Maternal viral infection causes global alterations in porcine fetal microglia
Maternal viral infection causes global alterations in porcine fetal microglia Open
Significance Mental health disorders account for approximately 14% of the worldwide burden of disease and affect people of all age groups and socioeconomic statuses. Prenatal exposure to maternal infection increases the risk of developing …
View article: Herring roe oil supplementation alters microglial cell gene expression and reduces peripheral inflammation after immune activation in a neonatal piglet model
Herring roe oil supplementation alters microglial cell gene expression and reduces peripheral inflammation after immune activation in a neonatal piglet model Open
View article: Dietary Iron Deficiency Impaired Peripheral Immunity but Did Not Alter Brain Microglia in PRRSV-Infected Neonatal Piglets
Dietary Iron Deficiency Impaired Peripheral Immunity but Did Not Alter Brain Microglia in PRRSV-Infected Neonatal Piglets Open
During the postnatal period the developing brain is vulnerable to insults including nutrient insufficiency and infection that may lead to disrupted development and cognitive dysfunction. Since iron deficiency (ID) often presents with immun…
View article: Effect of imidacloprid ingestion on immune responses to porcine reproductive and respiratory syndrome virus
Effect of imidacloprid ingestion on immune responses to porcine reproductive and respiratory syndrome virus Open
View article: Effects of iron deficiency upon neurodevelopment, metabolism, and inflammation
Effects of iron deficiency upon neurodevelopment, metabolism, and inflammation Open
The first few years of life are a critical period in neurodevelopment. During this time, multiple developmental processes occur in tandem, rendering the brain especially vulnerable to environmental insults. The coordination of complex neur…
View article: Postnatal Iron Deficiency Alters Brain Development in Piglets
Postnatal Iron Deficiency Alters Brain Development in Piglets Open