Explanipedia

Benchmarking large language models for personalized, biomarker-based health intervention recommendations Open

Hans Jarchow, Christoph Bobrowski, Steffi Falk, Andreas Hermann, Anton Kulaga , et al. · 2025

The Metabolic Transition Between Fasting and Feeding Alters Aging‐Associated Metabolites, Lowers BCAAs, and Stimulates FGF21 Production in Humans Open

María Lastra Cagigas, Nancy T. Santiappillai, Serena Commissati, Giovanni Fiorito, Andrius Masedunskas , et al. · 2025

Fasting‐based interventions are gaining momentum as strategies to modulate longevity. Conversely, the same metabolic adaptations that once ensured survival during starvation now contribute to the global obesity epidemic. While previous stu…

Alpha‐Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP / PS1 Mice Model of Alzheimer's Disease Open

Sheeja Navakkode, Brian K. Kennedy · 2025

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders, characterized by a progressive decline in cognitive function. Increasing evidence indicates that alpha‐ketoglutarate (AKG), a key metabolite in the tricarbo…

Spermidine for cognitive ageing: insights into observational and interventional studies Open

Luxin Yu, Bin Li, Na Li, Kaisy Xinhong Ye, Kyoungmi Lim , et al. · 2025

Bridging Physics and Aging Biology: Insights from the First Physics in Aging Biology Workshop Open

Maximilian Unfried, Morten Scheibye‐Knudsen, Uri Alon, Jan Gruber, Mogens H. Jensen , et al. · 2025

Recruitment evaluation of a gerotherapeutic randomized controlled trial testing alpha-ketoglutarate in biologically older, middle-aged adults (ABLE) Open

Zhi Meng Lim, Yi Ern Chew, Lihuan Guan, Weilan Wang, Muhammad Daniel Azlan Mahadzir , et al. · 2025

Promorphinan and bisaporphine alkaloids from Alseodaphne peduncularis Open

Sayed Mohammadhossein Modaresi, Premanand Krishnan, Wei‐Meng Lim, Ling‐Wei Hii, Kooi Yeong Khaw , et al. · 2025

Five previously undescribed benzylisoquinoline alkaloids were isolated from the leaves and stem-bark of Alseodaphne peduncularis. Among these, alseodaphnine (1) was characterized as a tetracyclic rearranged promorphinan alkaloid. Alseodaph…

The SG90 cohort of the oldest-old in Singapore Open

Lihuan Guan, Lei Feng, Anderson Li Yang Khoo, Kaisy Xinhong Ye, Roger Ho , et al. · 2025

Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery Open

Ming Ann Sim, Jorming Goh, Jasinda H. Lee, Jian Hua Tay, Francis Chee Kuan Tan , et al. · 2025

DoliClock: a lipid-based aging clock reveals accelerated aging in neurological disorders Open

Djakim Latumalea, Maximilian Unfried, Diogo Barardo, Jan Gruber, Brian K. Kennedy · 2025

Aging is a multifaceted process influenced by intrinsic and extrinsic factors, with lipid alterations playing a critical role in brain aging and neurological disorders. This study introduces DoliClock, a lipid-based biological aging clock …

How Can I Stay Healthy? – Benchmarking Large Language Models for Personalized and Biomarker-Based Intervention Recommendations Open

Hans Jarchow, Christoph Bobrowski, Steffi Falk, Andreas Hermann, Anton Kulaga , et al. · 2025

Background The integration of large language models (LLMs) into clinical workflows for diagnostics and intervention recommendations has gained interest due to their strong performance on various medical benchmarks. However, we lack benchma…

DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples Open

Jian Hua Tay, Yi Ern Chew, Weilan Wang, Zhi Meng Lim, Lihuan Guan , et al. · 2025

This study aims to evaluate differences between Infinium MethylationEPIC (EPICv1) and Infinium MethylationEPICv2 (EPICv2) arrays in estimating DNAm age with eleven DNAm clocks using buffy coat, peripheral blood mononuclear cell (PBMC), and…

LinAge2: providing actionable insights and benchmarking with epigenetic clocks Open

Sheng Fong, Kirill A. Denisov, Anastasiia A Nefedova, Brian K. Kennedy, Jan Gruber · 2025

Biological aging is marked by a decline in resilience at the cellular and systemic levels, driving an exponential increase in mortality risk. Here, we evaluate several clinical and epigenetic clocks for their ability to predict mortality, …

Prolonged fasting promotes systemic inflammation and platelet activation in humans: A medically supervised, water-only fasting and refeeding study Open

Serena Commissati, María Lastra Cagigas, Andrius Masedunskas, Giovanna Petrucci, Valeria Tosti , et al. · 2025

Perspectives on the essence and drivers of aging Open

Haim Cohen, Vera Gorbunova, Steve Horvath, Brian K. Kennedy, Wei Li , et al. · 2025

The Association of Physical Function and Physical Performance With DNA Methylation Clocks in Oldest-Old Living in Singapore—The SG90 Cohort Open

J.S.H. Tay, Weilan Wang, Lihuan Guan, Rajkumar Dorajoo, Lei Feng , et al. · 2025

Deoxyribonucleic acid (DNA) methylation (DNAm) clocks estimate biological age according to DNA methylation. This study investigated the associations between measures of physical function and physical performance and 10 DNAm clocks in the o…

Characterizing biomarkers of ageing in Singaporeans: the ABIOS observational study protocol Open

Jessica K. Lu, Weilan Wang, Janjira Soh, Elena Sandalova, Zhi Meng Lim , et al. · 2025

Benstolizidines A–E: Indolizidine- and piperidine-type alkaloids from Benstonea parva Open

Jin-Ning Chu, Premanand Krishnan, Shou-Ping Guan, Brian K. Kennedy, Jan Gruber , et al. · 2025

Promorphinan and Bisaporphine Alkaloids from Alseodaphne Peduncularis Open

Sayed Mohammadhossein Modaresi, Premanand Krishnan, Wei‐Meng Lim, Ling‐Wei Hii, Kooi Yeong Khaw , et al. · 2025

LinAge2: Providing actionable insights and benchmarking with epigenetic clocks Open

Sheng Fong, Kirill A. Denisov, Brian K. Kennedy, Jan Gruber · 2024

Biological aging is marked by a decline in resilience at the cellular and systemic levels, driving an exponential increase in mortality risk. Here, we evaluate several clinical and epigenetic clocks for their ability to predict mortality, …

Validation requirements for AI-based intervention-evaluation in aging and longevity research and practice Open

Georg Fuellen, Anton Kulaga, Sebastian Lobentanzer, Maximilian Unfried, Roberto A. Avelar , et al. · 2024

The field of aging and longevity research is overwhelmed by vast amounts of data, calling for the use of Artificial Intelligence (AI), including Large Language Models (LLMs), for the evaluation of geroprotective interventions. Such evaluat…

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity Open

Yihua Lyu, Qiang Fu, Dominika Wilczok, Kejun Ying, Aaron A. King , et al. · 2024

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at th…

The impact of short-lived controls on the interpretation of lifespan experiments and progress in geroscience – Through the lens of the “900-day rule” Open

Kamil Pabis, Diogo Barardo, Jan Gruber, Olga Sirbu, Marco Malavolta , et al. · 2024

Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes Open

Aarthi Ravikrishnan, Indrik Wijaya, Eileen Png, Kern Rei Chng, Eliza Xin Pei Ho , et al. · 2024

Validation Requirements for AI-based Intervention-Evaluation in Aging and Longevity Research and Practice Open

Georg Fuellen, Anton Kulaga, Sebastian Lobentanzer, Maximilian Unfried, Roberto A. Avelar , et al. · 2024

The field of aging and longevity research is overwhelmed by vast amounts of data, calling for the use of Artificial Intelligence (AI), including Large Language Models (LLMs), for the evaluation of geroprotective interventions. Such evaluat…

Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity Open

Sheeja Navakkode, Brian K. Kennedy · 2024

Ageing is characterized by a gradual decline in the efficiency of physiological functions and increased vulnerability to diseases. Ageing affects the entire body, including physical, mental, and social well-being, but its impact on the bra…

Late-life dietary folate restriction reduces biosynthesis without compromising healthspan in mice Open

Heidi M. Blank, Staci E. Hammer, Laurel Boatright, Courtney Roberts, Katarina E. Heyden , et al. · 2024

Folate is a vitamin required for cell growth and is present in fortified foods in the form of folic acid to prevent congenital abnormalities. The impact of low-folate status on life-long health is poorly understood. We found that limiting …

Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention Open

Sheng Fong, Kamil Pabis, Djakim Latumalea, Nomuundari Dugersuren, Maximilian Unfried , et al. · 2024

Clocks that measure biological age should predict all-cause mortality and give rise to actionable insights to promote healthy aging. Here we applied dimensionality reduction by principal component analysis to clinical data to generate a cl…

Therapy-induced senescence through the redox lens Open

Matius Robert, Brian K. Kennedy, Karen Crasta · 2024

A metabolic atlas of mouse aging Open

Steven E. Pilley, Dominik Awad, Djakim Latumalea, Edgar Esparza, Li Zhang , et al. · 2024

Humans are living longer, but this is accompanied by an increased incidence of age-related chronic diseases. Many of these diseases are influenced by age-associated metabolic dysregulation, but how metabolism changes in multiple organs dur…

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