Brian L. Edlow
YOU?
Author Swipe
View article: A probabilistic histological atlas of the human brain for MRI segmentation
A probabilistic histological atlas of the human brain for MRI segmentation Open
In human neuroimaging, brain atlases are essential for segmenting regions of interest (ROIs) and comparing subjects in a common coordinate frame. State-of-the-art atlases derived from histology1-3 provide exquisite three-dimensi…
View article: Unsupervised semi-automated MRI segmentation detects cortical lesion expansion in chronic traumatic brain injury
Unsupervised semi-automated MRI segmentation detects cortical lesion expansion in chronic traumatic brain injury Open
Traumatic brain injury (TBI) is a risk factor for neurodegeneration and cognitive decline, yet the underlying pathophysiologic mechanisms are incompletely understood. This gap in knowledge is in part related to a lack of reliable and effic…
View article: Automated <scp>MRI</scp> Segmentation of Brainstem Nuclei Critical to Consciousness
Automated <span>MRI</span> Segmentation of Brainstem Nuclei Critical to Consciousness Open
Although substantial progress has been made in mapping the connectivity of cortical networks responsible for conscious awareness, neuroimaging analysis of subcortical networks that modulate arousal (i.e., wakefulness) has been limited by a…
View article: Subcortical Hubs of Brain Networks Sustaining Human Consciousness
Subcortical Hubs of Brain Networks Sustaining Human Consciousness Open
Neuromodulation of subcortical network hubs by pharmacologic, electrical, or ultrasonic stimulation is a promising therapeutic strategy for patients with disorders of consciousness (DoC). However, optimal subcortical targets for therapeuti…
View article: Fast segmentation with the NextBrain histological atlas
Fast segmentation with the NextBrain histological atlas Open
Structural brain analysis at the subregion level offers critical insights into healthy aging and neurodegenerative diseases. The NextBrain histological atlas was recently introduced to support such fine-grained investigations, but its exis…
View article: Covert consciousness: what’s in a name?
Covert consciousness: what’s in a name? Open
Over the past decade, it has become apparent that up to 25% of behaviourally unresponsive patients with acute or chronic disorders of consciousness reveal high spatio-temporal complexity following a direct electrical or magnetic pulse to t…
View article: Neuroanatomical Basis of Coma in Acute Ischemic Stroke
Neuroanatomical Basis of Coma in Acute Ischemic Stroke Open
Background Acute ischemic stroke (AIS) can lead to profound disturbances in consciousness, including coma, which is associated with poor prognosis and increased mortality. Clarifying the lesion patterns that precipitate loss of consciousne…
View article: Emotional Processing After Severe Traumatic Brain Injury: Insights from Functional MRI and Pupillometry
Emotional Processing After Severe Traumatic Brain Injury: Insights from Functional MRI and Pupillometry Open
Objective Emotional dysfunction is a common consequence of severe traumatic brain injury (TBI), yet the mechanisms underlying these symptoms remain poorly understood. This study investigated whether brain network and autonomic mechanisms i…
View article: Publisher Correction: A human brain network linked to restoration of consciousness after deep brain stimulation.
Publisher Correction: A human brain network linked to restoration of consciousness after deep brain stimulation. Open
View article: Angiographic perfusion outperforms large artery vasospasm for predicting the impact of rescue therapy in subarachnoid hemorrhage
Angiographic perfusion outperforms large artery vasospasm for predicting the impact of rescue therapy in subarachnoid hemorrhage Open
Aneurysmal subarachnoid hemorrhage (aSAH) contributes disproportionately to stroke-related disability due to its prevalence in younger patients. Large vessel vasospasm complicates aSAH and is often treated with endovascular rescue therapy …
View article: Structural injuries are associated with better emotional wellbeing after traumatic brain injury
Structural injuries are associated with better emotional wellbeing after traumatic brain injury Open
Background Emotional disturbances are common after traumatic brain injury (TBI), yet the neuroanatomic basis of these sequalae remains unclear. We aimed to determine whether emotional wellbeing is associated with the extent and/or location…
View article: A human brain network linked to restoration of consciousness after deep brain stimulation
A human brain network linked to restoration of consciousness after deep brain stimulation Open
View article: Visualizing effective connectivity in the human brain
Visualizing effective connectivity in the human brain Open
View article: REcovery from DEXmedetomidine-Induced Unresponsiveness (REDEX): A Study Protocol for a Single Center, Parallel Arm, Non-Randomized, Controlled Pilot Trial in Healthy Volunteers
REcovery from DEXmedetomidine-Induced Unresponsiveness (REDEX): A Study Protocol for a Single Center, Parallel Arm, Non-Randomized, Controlled Pilot Trial in Healthy Volunteers Open
This pilot trial will report on the effect of repeated DEX exposure on the recovery period, and the investigation of state transitions will advance our scientific understanding of altered states of consciousness. REDEX will provide valuabl…
View article: Covert Brain Complexity in the Intensive Care Unit
Covert Brain Complexity in the Intensive Care Unit Open
Early detection of consciousness in critically ill patients with severe brain injuries has a profound impact on prognostication and decisions about whether to continue or limit life-sustaining therapy. The current state-of-the-art protocol…
View article: Covert Brain Complexity in the Intensive Care Unit
Covert Brain Complexity in the Intensive Care Unit Open
Early detection of consciousness in critically ill patients with severe brain injuries has a profound impact on prognostication and decisions about whether to continue or limit life-sustaining therapy. The current state-of-the-art protocol…
View article: Exploring the diagnostic and prognostic utility of resting state functional MRI connectivity in acute/sub-acute TBI
Exploring the diagnostic and prognostic utility of resting state functional MRI connectivity in acute/sub-acute TBI Open
Traumatic brain injury (TBI) is a leading cause of disability worldwide. Yet, our understanding of the mechanisms of this condition is limited, especially in the acute setting. Here, we investigated the relationship between functional conn…
View article: Probabilistic Mapping and Automated Segmentation of Human Brainstem White Matter Bundles
Probabilistic Mapping and Automated Segmentation of Human Brainstem White Matter Bundles Open
Brainstem white matter bundles are essential conduits for neural signaling involved in modulation of vital functions ranging from homeostasis to human consciousness. Their architecture forms the anatomic basis for brainstem connectomics, s…
View article: 0280 Subcortical Dynamics During Failures in Maintaining Alertness After Sleep Restriction in the Human Brain
0280 Subcortical Dynamics During Failures in Maintaining Alertness After Sleep Restriction in the Human Brain Open
Introduction Sleep restriction significantly impairs our ability to maintain alertness during tasks, leading to delayed responses, omissions, and even microsleeps. However, the neural mechanisms underlying these periods of extreme drowsine…
View article: Shared subcortical arousal systems across sensory modalities during transient modulation of attention
Shared subcortical arousal systems across sensory modalities during transient modulation of attention Open
View article: Three-dimensional fiber orientation mapping of ex vivo human brain at micrometer resolution
Three-dimensional fiber orientation mapping of ex vivo human brain at micrometer resolution Open
View article: Visualizing Effective Connectivity in the Human Brain
Visualizing Effective Connectivity in the Human Brain Open
To enhance mechanistic understanding of effective connectivity in the human brain, we created a tool that links high-temporal resolution transcranial magnetic stimulation electroencephalography (TMS-EEG) with high-spatial resolution diffus…
View article: Acute biomarkers of consciousness are associated with recovery after severe traumatic brain injury
Acute biomarkers of consciousness are associated with recovery after severe traumatic brain injury Open
Objective Determine whether acute behavioral, electroencephalography (EEG), and functional MRI (fMRI) biomarkers of consciousness are associated with outcome after severe traumatic brain injury (TBI). Methods Patients with acute severe TBI…
View article: Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury
Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury Open
Accumulating evidence of heterogeneous long-term outcomes after traumatic brain injury (TBI) has challenged longstanding approaches to TBI outcome classification that are largely based on global functioning. A lack of studies with clinical…
View article: Accounting for Withdrawal of Life-Sustaining Treatment in the Analysis of Traumatic Brain Injury Studies
Accounting for Withdrawal of Life-Sustaining Treatment in the Analysis of Traumatic Brain Injury Studies Open
Studies that aim to evaluate outcomes after severe traumatic brain injury (TBI) must account for patients who die after withdrawal of life-sustaining treatment (WLST). If we are willing to assume that some of the patients who die of WLST m…
View article: Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury
Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury Open
Accumulating evidence of heterogeneous long-term outcomes after traumatic brain injury (TBI) has challenged longstanding approaches to TBI outcome classification that are largely based on global functioning. A lack of studies with clinical…
View article: Impaired Sphenoparietal Venous Drainage Is Associated With Increased Risk of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
Impaired Sphenoparietal Venous Drainage Is Associated With Increased Risk of Vasospasm in Aneurysmal Subarachnoid Hemorrhage Open
Background Adequate venous drainage of brain parenchyma is essential to maintain cerebral perfusion and clearance of cerebrospinal fluid. The cortical vein opacification score (COVES) is a radiographic metric calculated from a computed tom…
View article: Cortical lesions and focal white matter injury are associated with attentional performance in chronic traumatic brain injury
Cortical lesions and focal white matter injury are associated with attentional performance in chronic traumatic brain injury Open
Cognitive impairment, often due to attentional deficits, is a primary driver of disability after traumatic brain injury. It remains unclear whether attentional deficits are caused by injury to specific brain structures or the total burden …
View article: Neuroinflammation at the Gray–White Matter Interface in Active-Duty U.S. Special Operations Forces
Neuroinflammation at the Gray–White Matter Interface in Active-Duty U.S. Special Operations Forces Open
Emerging evidence from autopsy studies indicates that interface astroglial scarring (IAS) at the gray-white matter junction is a pathological signature of repeated blast brain injury in military personnel. However, there is currently no
View article: Caring for Coma after Severe Brain Injury: Clinical Practices and Challenges to Improve Outcomes: An Initiative by the Curing Coma Campaign
Caring for Coma after Severe Brain Injury: Clinical Practices and Challenges to Improve Outcomes: An Initiative by the Curing Coma Campaign Open