Brian Levine
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View article: Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease
Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease Open
INTRODUCTION Currently, our ability to predict cognitive decline in Parkinson's disease is limited. METHODS In 234 dementia‐free PD patients, cognitive profiles at baseline were determined using cluster analysis and longitudinal associatio…
View article: Online Assessment of Individual Differences in Memory and Cognition: Risk and Resilience
Online Assessment of Individual Differences in Memory and Cognition: Risk and Resilience Open
Impaired episodic memory is a hallmark sign of medial temporal lobe damage from Alzheimer's disease. There is systematic variability across individuals in episodic memory capacity, particularly for autobiographical memory—or memory for eve…
View article: Adaptive episodic memory: How multiple memory representations drive behavior in humans and non-humans
Adaptive episodic memory: How multiple memory representations drive behavior in humans and non-humans Open
Episodic memory is a declarative long-term memory of a specific past experience. As such, it is multifaceted, encompassing both the objective and subjective components of that experience. These components can be flexibly represented at dif…
View article: Assessing Episodic and Semantic Autobiographical Recall in Healthy Older APOE ε4 Carriers
Assessing Episodic and Semantic Autobiographical Recall in Healthy Older APOE ε4 Carriers Open
The APOE E4 gene is associated with increased risk of developing sporadic Alzheimer's Disease. Several studies have focused on declarative memory, where episodic memory deficits are reported in E4 carriers, while semantic memory has receiv…
View article: Maximizing Fidelity of Neuropsychology Assessments in Fully Remote Studies (Preprint)
Maximizing Fidelity of Neuropsychology Assessments in Fully Remote Studies (Preprint) Open
BACKGROUND Remote, interdisciplinary, observational clinical studies and clinical trials are increasingly emerging in the scientific literature. Remote videoconference-based neuropsychological assessment offers numerous advantages, includ…
View article: The Curse of Imagery: Trait Object and Spatial Imagery Differentially Relate to Symptoms of Posttraumatic Stress Disorder
The Curse of Imagery: Trait Object and Spatial Imagery Differentially Relate to Symptoms of Posttraumatic Stress Disorder Open
Imagery is integral to autobiographical memory (AM). Past work has highlighted the benefits of high trait imagery on episodic AM, including faster, more detailed, and more vivid retrieval. However, these advantages may come with drawbacks:…
View article: The relation of eye movements to the occurrence of freezing of gait in Parkinson’s disease
The relation of eye movements to the occurrence of freezing of gait in Parkinson’s disease Open
Freezing of gait is a debilitating motor symptom in Parkinson's disease that significantly increases fall risk and impairs quality of life. The poorly understood pathophysiology of freezing of gait presents challenges for early prediction …
View article: White matter tract correlations with spoken language in cerebrovascular disease
White matter tract correlations with spoken language in cerebrovascular disease Open
Assessment of spoken language is a promising marker for cognitive impairment in individuals with cerebrovascular disease. However, the underlying neurological basis for spoken language beyond single words and sentences remains poorly defin…
View article: Investigating the contribution of subcortical salience network structures to a measure of social cognition across neurodegenerative diseases
Investigating the contribution of subcortical salience network structures to a measure of social cognition across neurodegenerative diseases Open
Background Social cognition is impacted early in the disease progression of many neurodegenerative diseases (ND). The Salience network (SN) is an intrinsically connected brain network responsible for social cognitive function. Keys hubs of…
View article: Individual Differences in Visual vs. Semantic Neural Reactivation: Evidence from Severely Deficient Autobiographical Memory (SDAM)
Individual Differences in Visual vs. Semantic Neural Reactivation: Evidence from Severely Deficient Autobiographical Memory (SDAM) Open
Visual memory is intricately linked to the reinstatement of low-level visual features, such as edges and luminosity, within the early visual cortex. However, individuals with Severely Deficient Autobiographical Memory (SDAM) cannot vividly…
View article: Remembrance with gazes passed: Eye movements precede continuous recall of episodic details of real-life events
Remembrance with gazes passed: Eye movements precede continuous recall of episodic details of real-life events Open
Autobiographical memory entails reconstructing the visual features of past events. Eye movements are associated with vivid autobiographical recollection, but this research has yet to capitalize on the high temporal resolution of eye-tracki…
View article: Visual imagery and STEM occupational attainment: Gender matters
Visual imagery and STEM occupational attainment: Gender matters Open
Science, technology, engineering and mathematical (STEM) occupations are crucial for economic growth and individual financial stability, yet there is a STEM labour shortage, particularly among women. We examined how individual differences …
View article: The curse of imagery: Trait object and spatial imagery differentially relate to trauma and stress outcomes
The curse of imagery: Trait object and spatial imagery differentially relate to trauma and stress outcomes Open
Imagery is integral to autobiographical memory (AM). Past work has highlighted that the benefits of high trait imagery on episodic AM include faster, more detailed, and more vivid retrieval. However, these advantages may come with drawback…
View article: The curse of imagery: Trait object and spatial imagery differentially relate to symptoms of posttraumatic stress disorder
The curse of imagery: Trait object and spatial imagery differentially relate to symptoms of posttraumatic stress disorder Open
Imagery is integral to autobiographical memory (AM). Past work has highlighted the benefits of high trait imagery on episodic AM, including faster, more detailed, and more vivid retrieval. However, these advantages may come with drawbacks:…
View article: Remembrance with gazes passed: Eye movements precede continuous recall of episodic details of real-life events
Remembrance with gazes passed: Eye movements precede continuous recall of episodic details of real-life events Open
Autobiographical memory entails reconstructing the visual features of past events. Eye movements are associated with vivid autobiographical recollection, but this research has yet to capitalize on the high temporal resolution of eye-tracki…
View article: Sleep selectively and durably enhances real-world sequence memory
Sleep selectively and durably enhances real-world sequence memory Open
Sleep is thought to play a critical role in the retention of episodic memories. Yet it remains unclear whether and how sleep actively transforms memory for specific experiences. More generally, little is known about sleep’s effects on memo…
View article: Assessing the impact of falls on neuropsychiatric symptoms in patients with neurodegenerative disease
Assessing the impact of falls on neuropsychiatric symptoms in patients with neurodegenerative disease Open
Background Falls are the most common injury faced by older adults and those with neurodegenerative diseases. Falls can result in concussion/mild traumatic brain injury(mTBI). Concussions in older adults or those with neurodegenerative dise…
View article: Neuroinflammatory biomarkers in neurodegenerative disease: Insights from the ONDRI Cohort
Neuroinflammatory biomarkers in neurodegenerative disease: Insights from the ONDRI Cohort Open
Background Neuroinflammation (NI) has been implicated in both the pathogenesis of and neuroprotection against neurodegenerative diseases (NDs)(Psenicka et al., 2021). Plasma glial fibrillary acidic protein (GFAP), and Neurofilament light (…
View article: Neuroinflammatory biomarkers in neurodegenerative disease: Insights from the ONDRI Cohort
Neuroinflammatory biomarkers in neurodegenerative disease: Insights from the ONDRI Cohort Open
Background Neuroinflammation (NI) has been implicated in both the pathogenesis of and neuroprotection against neurodegenerative diseases (NDs)(Psenicka et al., 2021). Plasma glial fibrillary acidic protein (GFAP), and Neurofilament light (…
View article: Effects of Healthy and Neuropathological Aging on Autobiographical Memory: A Meta-Analysis of Studies Using the Autobiographical Interview
Effects of Healthy and Neuropathological Aging on Autobiographical Memory: A Meta-Analysis of Studies Using the Autobiographical Interview Open
Objectives A meta-analytic review was conducted to assess the effects of healthy aging, amnestic mild cognitive impairment (MCI), and Alzheimer’s disease (AD) on naturalistic autobiographical memory using the Autobiographical Interview, a …
View article: Cover Image
Cover Image Open
The cover image is based on the Advanced Review What about “space” is important for episodic memory? by Carina L. Fan et al., https://doi.org/10.1002/wcs.1645 . Image Credit: Sadie Levine. image
View article: Evoking Episodic and Semantic Details with Instructional Manipulation: the Semantic Autobiographical Interview
Evoking Episodic and Semantic Details with Instructional Manipulation: the Semantic Autobiographical Interview Open
Most measures of naturalistic human memory instruct participants to recall personally-experienced episodes in narrative format. These narratives contain non-episodic details, such as general knowledge of the world, or personal knowledge ab…
View article: Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases
Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases Open
Oculomotor tasks generate a potential wealth of behavioural biomarkers for neurodegenerative diseases. Overlap between oculomotor and disease-impaired circuitry reveals the location and severity of disease processes via saccade parameters …
View article: What about “space” is important for episodic memory?
What about “space” is important for episodic memory? Open
Early cognitive neuroscientific research revealed that the hippocampus is crucial for spatial navigation in rodents, and for autobiographical episodic memory in humans. Researchers quickly linked these streams to propose that the human hip…
View article: Visualization of latent components assessed in O*Net occupations (VOLCANO): A robust method for standardized conversion of occupational labels to ratio scale format
Visualization of latent components assessed in O*Net occupations (VOLCANO): A robust method for standardized conversion of occupational labels to ratio scale format Open
Occupations are typically characterized in nominal form, a format that limits options for hypothesis testing and data analysis. We drew upon ratings of knowledge, skills, and abilities for 966 occupations listed in the US Department of Lab…
View article: White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease: results from the Ontario Neurodegenerative Diseases Research Initiative
White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease: results from the Ontario Neurodegenerative Diseases Research Initiative Open
Background and purpose The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, and in the presence of brain white matter hyperintensities (WMHs) cognitive and motor impairments seem to be aggravated. …
View article: Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function
Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function Open
Objective Neuropsychiatric symptoms (NPS) are prevalent in neurodegenerative disorders, however, their frequency and impact on function across different disorders is not well understood. We compared the frequency and severity of NPS across…
View article: Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke
Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke Open
Background Cerebral small vessel disease is associated with higher ratios of soluble‐epoxide hydrolase derived linoleic acid diols (12,13‐dihydroxyoctadecenoic acid [DiHOME] and 9,10‐DiHOME) to their parent epoxides (12(13)‐epoxyoctadeceno…