Brian L. Hoh
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View article: Patient Follow-up After Endovascular Treatment of Cerebral Aneurysms: Identifiable Barriers and Implications for Treatment Decisions
Patient Follow-up After Endovascular Treatment of Cerebral Aneurysms: Identifiable Barriers and Implications for Treatment Decisions Open
BACKGROUND AND OBJECTIVES: Cerebral aneurysms are the major cause of spontaneous subarachnoid hemorrhage, and a common treatment is endovascular embolization. Aneurysmal recurrence after embolization is frequent, and clinical follow-up to …
View article: Parkinson’s paradox: alpha-synuclein’s selective strike on SNc dopamine neurons over VTA
Parkinson’s paradox: alpha-synuclein’s selective strike on SNc dopamine neurons over VTA Open
A central question in Parkinson’s disease (PD) and related synucleinopathies research is why dopamine neurons in the substantia nigra pars compacta (SNc) are more vulnerable than those in the ventral tegmental area (VTA). We investigated h…
View article: Role of biliverdin reductase, a heme degradation pathway enzyme, in the development of vasospasm after subarachnoid hemorrhage
Role of biliverdin reductase, a heme degradation pathway enzyme, in the development of vasospasm after subarachnoid hemorrhage Open
Background Subarachnoid hemorrhage (SAH) is a life-threatening condition with high mortality and significant neurological morbidity, often complicated by delayed cerebral ischemia (DCI) and vasospasm. Heme metabolites such as biliverdin (B…
View article: Parkinson’s Paradox: Alpha-synuclein’s Selective Strike on SNc Dopamine Neurons over VTA
Parkinson’s Paradox: Alpha-synuclein’s Selective Strike on SNc Dopamine Neurons over VTA Open
In synucleinopathies, including Parkinson’s disease (PD), dopamine neurons in the substantia nigra pars compacta (SNc) exhibit greater vulnerability to degeneration than those in the ventral tegmental area (VTA). While α-synuclein (αSyn) p…
View article: Design and early progress of the Comparison of Anticoagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA) trial
Design and early progress of the Comparison of Anticoagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA) trial Open
Background: The usual antithrombotic treatment for symptomatic intracranial atherosclerotic stenosis (ICAS) consists of dual treatment with clopidogrel and aspirin for 90 days followed by aspirin alone but the risk of recurrent stroke rema…
View article: Role of the Unique Secreted Peptide Adropin in Various Physiological and Disease States
Role of the Unique Secreted Peptide Adropin in Various Physiological and Disease States Open
Adropin, a secreted peptide hormone identified in 2008, plays a significant role in regulating energy homeostasis, glucose metabolism, and lipid metabolism. Its expression is linked to dietary macronutrient intake and is influenced by meta…
View article: PP4.1 – 00179 Distinct Immunity Signatures Uncover Diverse Profiles Among Elite HIV Controllers
PP4.1 – 00179 Distinct Immunity Signatures Uncover Diverse Profiles Among Elite HIV Controllers Open
View article: Rationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design
Rationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design Open
Background Acute post-subarachnoid hemorrhage (SAH) headaches are common and severe. Management strategies for post-SAH headaches are limited, with heavy reliance on opioids, and pain control is overall poor. Pterygopalatine fossa (PPF) ne…
View article: Subarachnoid hemorrhage-associated brain injury and neurobehavioral deficits are reversed with synthetic adropin treatment through sustained Ser1179 phosphorylation of endothelial nitric oxide synthase
Subarachnoid hemorrhage-associated brain injury and neurobehavioral deficits are reversed with synthetic adropin treatment through sustained Ser1179 phosphorylation of endothelial nitric oxide synthase Open
Background Subarachnoid hemorrhage (SAH) is a life-threatening vascular condition without satisfactory treatment options. The secreted peptide adropin is highly expressed in the human brain and has neuroprotective effects in brain injury m…
View article: Corrigendum: Grade 3 Meningioma Survival and Recurrence Outcomes in an International Multicenter Cohort
Corrigendum: Grade 3 Meningioma Survival and Recurrence Outcomes in an International Multicenter Cohort Open
[This corrects the article DOI: 10.1055/s-0044-1779888.].
View article: Assessment of Blood Loss during Neuroendovascular Procedures
Assessment of Blood Loss during Neuroendovascular Procedures Open
(1) Background: Neuroendovascular procedures have generally been considered to have minor or inconsequential blood loss. No study, however, has investigated this question. The purpose of this study is to quantify the blood loss associated …
View article: Focused Update on Intracranial Atherosclerosis: Introduction, Highlights, and Knowledge Gaps
Focused Update on Intracranial Atherosclerosis: Introduction, Highlights, and Knowledge Gaps Open
View article: Neutrophils: Novel Contributors to Estrogen‐Dependent Intracranial Aneurysm Rupture Via Neutrophil Extracellular Traps
Neutrophils: Novel Contributors to Estrogen‐Dependent Intracranial Aneurysm Rupture Via Neutrophil Extracellular Traps Open
Background Intracranial aneurysms (IAs) are more prevalent in women than men, and aneurysmal subarachnoid hemorrhage disproportionately affects postmenopausal women. These sex differences suggest estrogen protects against IA progression th…
View article: How do children fare compared with adults? Comparing relative outcomes after thrombectomy for acute ischemic stroke due to large-vessel occlusion
How do children fare compared with adults? Comparing relative outcomes after thrombectomy for acute ischemic stroke due to large-vessel occlusion Open
View article: Central Retinal Artery Occlusion: A Review of Pathophysiological Features and Management
Central Retinal Artery Occlusion: A Review of Pathophysiological Features and Management Open
Central retinal artery occlusion (CRAO) is a form of acute ischemic stroke that results in painless vision loss attributable to retinal infarction. A keen understanding of clinical presentation and underlying pathophysiological features is…
View article: Grade 3 meningioma survival and recurrence outcomes in an international multicenter cohort
Grade 3 meningioma survival and recurrence outcomes in an international multicenter cohort Open
OBJECTIVE Grade 3 meningioma represents a rare meningioma subtype, for which limited natural history data are available. The objective of this study was to identify demographics and pathologic characteristics, clinical and functional statu…
View article: NLRP3 inflammasome inhibition protects against intracranial aneurysm rupture and alters the phenotype of infiltrating macrophages
NLRP3 inflammasome inhibition protects against intracranial aneurysm rupture and alters the phenotype of infiltrating macrophages Open
Background Aneurysmal subarachnoid hemorrhage is a devastating cerebrovascular disease associated with high morbidity and mortality. Macrophage-mediated mural inflammation is a key pathogenic component contributing to aneurysm rupture. Obj…
View article: O-048 Comparing outcomes after thrombectomy for acute ischemic stroke due to large-vessel occlusion: children vs. adults – a systematic review and meta-analysis
O-048 Comparing outcomes after thrombectomy for acute ischemic stroke due to large-vessel occlusion: children vs. adults – a systematic review and meta-analysis Open
Background Endovascular mechanical thrombectomy (EVT) is a standard treatment for acute ischemic stroke secondary to large-vessel occlusion (LVO) in adults. Although EVT is performed in children, data regarding safety and efficacy is less …
View article: 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association
2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association Open
Aim: The “2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage” replaces the 2012 “Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage.” The 2023 guideline is intended to provide patient-cen…
View article: Intravenous nicardipine for Japanese patients with acute intracerebral hemorrhage: an individual participant data analysis
Intravenous nicardipine for Japanese patients with acute intracerebral hemorrhage: an individual participant data analysis Open
The effects of acute systolic blood pressure levels achieved with continuous intravenous administration of nicardipine for Japanese patients with acute intracerebral hemorrhage on clinical outcomes were determined. A systematic review and …
View article: Investigation and modulation of interleukin-6 following subarachnoid hemorrhage: targeting inflammatory activation for cerebral vasospasm
Investigation and modulation of interleukin-6 following subarachnoid hemorrhage: targeting inflammatory activation for cerebral vasospasm Open
View article: Cost Comparison: Evaluating Transfemoral and Transradial Access for Diagnostic Cerebral Angiography
Cost Comparison: Evaluating Transfemoral and Transradial Access for Diagnostic Cerebral Angiography Open
Background Modern medicine necessitates the delivery of increasingly complex health care while minimizing cost. Transradial access (TRA) for neuroendovascular procedures is becoming more common as accumulating data demonstrate fewer compli…
View article: Investigation and Modulation of Interleukin 6 following Subarachnoid Hemorrhage: Targeting Inflammatory Activation for Cerebral Vasospasm
Investigation and Modulation of Interleukin 6 following Subarachnoid Hemorrhage: Targeting Inflammatory Activation for Cerebral Vasospasm Open
Background: Cerebral vasospasm (CV) can contribute significant morbidity for subarachnoid hemorrhage (SAH) patients. A key unknown is how CV induction is triggered following SAH. Methods: human aneurysmal blood was collected for evaluation…
View article: Combination release of chemokines from coated coils to target aneurysm healing
Combination release of chemokines from coated coils to target aneurysm healing Open
Background Monocyte chemoattractant protein 1 (MCP-1) and osteopontin (OPN) have been identified separately as key mediators of the aneurysm healing process following coil embolization in the rodent model. The ability of protein coated coi…
View article: Sensorineural hearing loss due to delayed cerebral ischemia in bilateral auditory cortices following aneurysmal subarachnoid hemorrhage: illustrative case
Sensorineural hearing loss due to delayed cerebral ischemia in bilateral auditory cortices following aneurysmal subarachnoid hemorrhage: illustrative case Open
BACKGROUND Recognizing rare signs of delayed cerebral ischemia (DCI) is crucial to caring for patients with subarachnoid hemorrhage. The authors presented a case of central hearing loss that occurred during the clinical course of a patient…
View article: Risk of Early Versus Later Rebleeding From Dural Arteriovenous Fistulas With Cortical Venous Drainage
Risk of Early Versus Later Rebleeding From Dural Arteriovenous Fistulas With Cortical Venous Drainage Open
Background: Cranial dural arteriovenous fistulas with cortical venous drainage are rare lesions that can present with hemorrhage. A high rate of rebleeding in the early period following hemorrhage has been reported, but published long-term…
View article: Severe headache trajectory following aneurysmal subarachnoid hemorrhage: the association with lower sodium levels
Severe headache trajectory following aneurysmal subarachnoid hemorrhage: the association with lower sodium levels Open
We identified two distinct post-aSAH headache pain trajectory cohorts and identified an association with age, analgesia, and sodium levels. Future prospective studies considering sodium homeostasis and volume status under standardized anal…
View article: The Evolution of Endovascular Therapy for Intracranial Aneurysms: Historical Perspective and Next Frontiers
The Evolution of Endovascular Therapy for Intracranial Aneurysms: Historical Perspective and Next Frontiers Open
The history of cerebral aneurysm treatment has a rich and storied past with multiple notable luminaries contributing insights. The modern era has transitioned from primarily clip ligation to increasing use of endovascular therapy. Even mor…
View article: Outcomes of Mechanical Thrombectomy for Patients With Stroke Presenting With Low Alberta Stroke Program Early Computed Tomography Score in the Early and Extended Window
Outcomes of Mechanical Thrombectomy for Patients With Stroke Presenting With Low Alberta Stroke Program Early Computed Tomography Score in the Early and Extended Window Open
In this cohort study, more than 1 in 5 patients presenting with an ASPECTS of 2 to 5 achieved 90-day functional independence after MT. A favorable outcome was nearly 5 times more likely for patients with low ASPECTS who had successful reca…
View article: Understanding the genetics of intracranial aneurysms: A primer
Understanding the genetics of intracranial aneurysms: A primer Open