Brian M. Davis
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View article: Integration of Multiomic and Multi-phenotypic Data Identifies Biological Pathways Associated with Physical Fitness
Integration of Multiomic and Multi-phenotypic Data Identifies Biological Pathways Associated with Physical Fitness Open
Unraveling the complex associations between human phenotypes and molecular pathways can pave the way to improved health and performance, but faces a fundamental challenge: the measurable genes, proteins, and metabolites vastly outnumber th…
View article: Large Language Models for Detecting Bias in Job Descriptions
Large Language Models for Detecting Bias in Job Descriptions Open
This study explores the application of large language (LLM) models for detecting implicit bias in job descriptions, an important concern in human resources that shapes applicant pools and influences employer perception. We compare differen…
View article: Neural Activity And The Immune Response In The Colon
Neural Activity And The Immune Response In The Colon Open
View article: Visceral Nociception Developed As A Consequence Of The Chemotherapeutic Treatment In An Ovarian Rodent Model
Visceral Nociception Developed As A Consequence Of The Chemotherapeutic Treatment In An Ovarian Rodent Model Open
View article: Data from Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma
Data from Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma Open
Perineural tumor invasion of intrapancreatic nerves, neurogenic inflammation, and tumor metastases along extrapancreatic nerves are key features of pancreatic malignancies. Animal studies show that chronic pancreatic inflammation produces …
View article: Supplementary Tables 1 - 4 and Figures 1 - 2 from Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma
Supplementary Tables 1 - 4 and Figures 1 - 2 from Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma Open
PDF file - 457KB, Supplementary Table 1. qRT-PCR murine primer sequences used in this study. Supplementary Table 2. qRT-PCR human primer sequences used in this study. Supplementary Table 3. Comparison of changes in house keeping genes duri…
View article: Supplementary Tables 1 - 4 and Figures 1 - 2 from Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma
Supplementary Tables 1 - 4 and Figures 1 - 2 from Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma Open
PDF file - 457KB, Supplementary Table 1. qRT-PCR murine primer sequences used in this study. Supplementary Table 2. qRT-PCR human primer sequences used in this study. Supplementary Table 3. Comparison of changes in house keeping genes duri…
View article: Data from Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma
Data from Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma Open
Perineural tumor invasion of intrapancreatic nerves, neurogenic inflammation, and tumor metastases along extrapancreatic nerves are key features of pancreatic malignancies. Animal studies show that chronic pancreatic inflammation produces …
View article: Abnormal enteric nervous system and motor activity in the ganglionic proximal bowel of Hirschsprung’s disease
Abnormal enteric nervous system and motor activity in the ganglionic proximal bowel of Hirschsprung’s disease Open
Hirschsprung’s disease (HSCR) is a congenital defect in which the enteric nervous system (ENS) does not develop in the distal bowel, requiring surgical removal of the portions of bowel without ENS ganglia (‘aganglionic’) and reattachment o…
View article: Retrospective Analysis of Healthcare Resource Use, Treatment Patterns, and Treatment-related Events in Patients with Huntington’s Disease–associated Chorea Initiated on Tetrabenazine
Retrospective Analysis of Healthcare Resource Use, Treatment Patterns, and Treatment-related Events in Patients with Huntington’s Disease–associated Chorea Initiated on Tetrabenazine Open
Background: Huntington’s disease (HD) is a multifaceted neurodegenerative disorder characterized by involuntary movements, specifically chorea, as well as behavioral and psychiatric disturbance, and cognitive dysfunction. Tetrabenazine was…
View article: Comparative Assessment of Pulsed and Continuous LED UV-A Lighting for Disinfection of Contaminated Surfaces
Comparative Assessment of Pulsed and Continuous LED UV-A Lighting for Disinfection of Contaminated Surfaces Open
The germicidal efficacy of LED UV-A lighting has scarcely been compared in continuous and pulsed modes for contaminated surfaces. Herein, we compare the disinfection properties of pulsed versus continuous lighting at equal irradiances usin…
View article: Neuronally expressed PDL1, not PD1, suppresses acute nociception
Neuronally expressed PDL1, not PD1, suppresses acute nociception Open
View article: High resolution DLP stereolithography to fabricate biocompatible hydroxyapatite structures that support osteogenesis
High resolution DLP stereolithography to fabricate biocompatible hydroxyapatite structures that support osteogenesis Open
Lithography based additive manufacturing techniques, specifically digital light processing (DLP), are considered innovative manufacturing techniques for orthopaedic implants because of their potential for construction of complex geometries…
View article: A morganucodontan (Mammaliaformes) from the Upper Jurassic Morrison Formation, Utah, USA
A morganucodontan (Mammaliaformes) from the Upper Jurassic Morrison Formation, Utah, USA Open
Davis, Brian M., Jäger, Kai R.K., Rougier, Guillermo W., Trujillo, Kelli, Chamberlain, Kevin (2022): A morganucodontan mammaliaform from the Upper Jurassic Morrison Formation, Utah, USA. Acta Palaeontologica Polonica 67 (1): 77-93, DOI: 10…
View article: A student of everything: Richard L. Cifelli’s broad influence on mammalian paleontology and beyond
A student of everything: Richard L. Cifelli’s broad influence on mammalian paleontology and beyond Open
Davis, Brian M., Haiar, Brooke K., Wedel, Mathew J. (2022): A student of everything: Richard L. Cifelli's broad influence on mammalian paleontology and beyond. Acta Palaeontologica Polonica 67 (1): 3-4, DOI: 10.4202/app.00988.2022, URL: ht…
View article: 638: Demonstration of pharmacologic N1303 K CFTR rescue in heterologous and human tissue-based model systems
638: Demonstration of pharmacologic N1303 K CFTR rescue in heterologous and human tissue-based model systems Open
View article: Unique Neural Circuit Connectivity of Mouse Proximal, Middle, and Distal Colon Defines Regional Colonic Motor Patterns
Unique Neural Circuit Connectivity of Mouse Proximal, Middle, and Distal Colon Defines Regional Colonic Motor Patterns Open
View article: Optogenetic activation of the distal colon epithelium engages enteric nervous system circuits to initiate motility patterns
Optogenetic activation of the distal colon epithelium engages enteric nervous system circuits to initiate motility patterns Open
Using an all-optical approach to measure real-time cell-to-cell communication responsible for colon functions, we show that selective optogenetic stimulation of distal colon epithelium produced activity in myenteric neurons, as measured wi…
View article: Synaptic Components, Function and Modulation Characterized by GCaMP6f Ca2+ Imaging in Mouse Cholinergic Myenteric Ganglion Neurons
Synaptic Components, Function and Modulation Characterized by GCaMP6f Ca2+ Imaging in Mouse Cholinergic Myenteric Ganglion Neurons Open
The peristaltic contraction and relaxation of intestinal circular and longitudinal smooth muscles is controlled by synaptic circuit elements that impinge upon phenotypically diverse neurons in the myenteric plexus. While electrophysiologic…
View article: Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis
Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis Open
View article: scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3
scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3 Open
Single cell analyses defined genes differentially expressed in myenteric neuron subtypes and new roles for TBX3, GDNF and NRTN. These data facilitate molecular diagnostic studies and novel therapeutics for bowel motility disorders.
View article: <i>Scalaridelphys</i> nom. nov., a new replacement name for <i>Scalaria</i> Cohen et al., 2020 (Marsupialiformes, Aquiladelphidae)
<i>Scalaridelphys</i> nom. nov., a new replacement name for <i>Scalaria</i> Cohen et al., 2020 (Marsupialiformes, Aquiladelphidae) Open
This article refers to:Geologically Oldest Pediomyoidea (Mammalia, Marsupialiformes) from the Late Cretaceous of North America, with Implications for Taxonomy and Diet of Earliest Late Cretaceous Mammals
View article: Future directions in preclinical and translational cancer neuroscience research
Future directions in preclinical and translational cancer neuroscience research Open
View article: Optogenetic inhibition of the colon epithelium reduces hypersensitivity in a mouse model of inflammatory bowel disease
Optogenetic inhibition of the colon epithelium reduces hypersensitivity in a mouse model of inflammatory bowel disease Open
Visceral pain is a prevalent symptom of inflammatory bowel disease that can be difficult to treat. Pain and hypersensitivity are mediated by extrinsic primary afferent neurons (ExPANs) that innervate the colon. Recent studies indicate that…
View article: Sympathetic Input to Multiple Cell Types in Mouse and Human Colon Produces Region-Specific Responses
Sympathetic Input to Multiple Cell Types in Mouse and Human Colon Produces Region-Specific Responses Open
View article: Unique Molecular Characteristics of Visceral Afferents Arising from Different Levels of the Neuraxis: Location of Afferent Somata Predicts Function and Stimulus Detection Modalities
Unique Molecular Characteristics of Visceral Afferents Arising from Different Levels of the Neuraxis: Location of Afferent Somata Predicts Function and Stimulus Detection Modalities Open
Viscera receive innervation from sensory ganglia located adjacent to multiple levels of the brainstem and spinal cord. Here we examined whether molecular profiling could be used to identify functional clusters of colon afferents from thora…
View article: Clinically Actionable Strategies for Studying Neural Influences in Cancer
Clinically Actionable Strategies for Studying Neural Influences in Cancer Open
View article: Unique molecular characteristics of visceral afferents arising from different levels of the neuraxis: location of afferent somata predicts function and stimulus detection modalities
Unique molecular characteristics of visceral afferents arising from different levels of the neuraxis: location of afferent somata predicts function and stimulus detection modalities Open
Visceral organs receive neural innervation from sensory ganglia located adjacent to multiple levels of the brainstem and spinal cord. Here we examined whether molecular profiling could be used to identify functional clusters of colon affer…
View article: Optogenetic inhibition of colon epithelium reduces hypersensitivity in a mouse model of inflammatory bowel disease
Optogenetic inhibition of colon epithelium reduces hypersensitivity in a mouse model of inflammatory bowel disease Open
Visceral pain is a prevalent symptom of inflammatory bowel disease (IBD) that can be difficult to treat. Pain and hypersensitivity are mediated by extrinsic primary afferent neurons (ExPANs) that innervate the colon. Recent studies indicat…
View article: Machine learning and ligand binding predictions: A review of data, methods, and obstacles
Machine learning and ligand binding predictions: A review of data, methods, and obstacles Open