Explanipedia

Corrigendum to “Level of consciousness at discharge and associations with outcome after ischemic stroke” [Journal of the Neurological Sciences, Volume 390 (2018): 102–107] Open

Michael Reznik, Brian Mac Grory, Shawna M Cutting, Bradford Thompson, Karen L. Furie · 2025

Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection Open

Ahmad Nehme, Liqi Shu, Marion Boulanger, Junpeng Ma, Salter Arms , et al. · 2025

Importance Fibromuscular dysplasia (FMD) is found in 6 to 14% of patients with spontaneous cervical artery dissection (SCEAD) and may be associated with recurrent SCEAD. Objective To evaluate the correlates of FMD in patients with SCEAD an…

Corrigendum to “Mobile stroke units: Beyond thrombolysis” [Journal of the Neurological Sciences, Volume 463 (2024): 123123] Open

Neeharika Krothapalli, David Hasan, Jay B. Lusk, Sven Poli, Shazam Hussain , et al. · 2025

Cardiovascular Multimorbidity in Older Adults in the United States by Race and Sex Open

Michael D. Green, Robert J. Mentz, Stephen J. Greene, Bradley G. Hammill, Utibe R. Essien , et al. · 2025

Harnessing Routinely Collected Health Data for Global Monitoring of Stroke: Roadmap and Vision for INSPIRE-STROKE Open

Lachlan L. Dalli, Muideen T. Olaiya, Amy Yu, Mathew J. Reeves, Dominique A. Cadilhac , et al. · 2025

Introduction: Sustainable and low-cost data systems for national and global surveillance of stroke are urgently needed to address the growing burden of stroke. Routinely collected health data (including registries and administrative data) …

Intravenous Thrombolysis for Acute Central Retinal Artery Occlusion: Protocol For a Systematic Review and Individual Participant Data Meta-Analysis of Randomized Controlled Trials Open

Brian Mac Grory, Cécile Preterre, Pierre Lebranchu, Stephen James Ryan, Øystein Kalsnes Jørstad , et al. · 2025

Importance Central retinal artery occlusion (CRAO) is a disabling subtype of acute ischemic stroke. It is not known whether intravenous (IV) thrombolysis delivered within 4.5 hours of time last known well (LKW) improves visual outcomes. St…

Photon-Counting Computed Tomography for Evaluation of Coiled Intracranial Aneurysms Open

Brian Mac Grory, Amanda Randles, David Urick, Fides R. Schwartz, David Hasan , et al. · 2025

Virtual monoenergetic images combined with metal artifact reduction algorithms created from PCCT scans conferred excellent visualization of previously-treated intracranial aneurysms and adjacent vasculature. It was feasible to extend these…

Uptake and Safety Profile of Anti-Amyloid Immunotherapies in Routine Clinical Practice Open

Jay B. Lusk, Kate Vinita Fitch, Kim G. Johnson, Andy Liu, Jennifer L. Lund , et al. · 2025

Introduction Anti - amyloid immunotherapies are approved by the United States Food and Drug Administration (FDA) for the treatment of Alzheimer’s disease. The adoption and safety profile of these medications in routine clinical practice ha…

Endovascular management of tandem occlusions: current evidence and future directions Open

Neeharika Krothapalli, Jeremy J. Heit, Adam de Havenon, Aneesh B. Singhal, Eric S. Sussman , et al. · 2025

Tandem occlusions (TOs)—concurrent extracranial large artery steno-occlusion and intracranial artery occlusion—represent a challenging clinical predicament. Stroke due to TOs is associated with high mortality and morbidity. Because of incr…

Prehospital notification in acute stroke: a retrospective cohort study Open

Joshua Kimbrell, Aditya C. Shekhar, Jacob Stebel, Dana Poke, Jacob Geldner , et al. · 2025

Prehospital notification is associated with reduced door-to-CT and door-to-IVT times. Prehospital notification in nationwide quality improvement efforts may improve stroke care.

Incidence and prevalence of dementia among US Medicare beneficiaries, 2015-21: population based study Open

Beau Blass, Cassie B. Ford, Samir Soneji, Lindsay Zepel, Talita D’Aguiar Rosa , et al. · 2025

Objective To determine the incidence and prevalence of dementia in a nationally representative cohort of US Medicare beneficiaries, stratified by important subgroups. Design Population based study. Setting Nationwide study between 2015 and…

Antithrombotic Trends Before and After Publication of Randomized Clinical Trials in Cervical Artery Dissection: A Secondary Analysis of the STOP‐CAD Study Open

Mary Penckofer, Liqi Shu, Lukas Strelecky, Shadi Yaghi, Nils Henninger , et al. · 2025

Background Two randomized clinical trials have failed to demonstrate the superiority of anticoagulation over antiplatelet therapy in acute cervical artery dissection, with many patients still receiving anticoagulation despite bleeding risk…

Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke Open

Justin F. Rousseau, Jeremy M. Weber, Brooke Alhanti, Jeffrey L. Saver, Steven R. Messé , et al. · 2025

Importance Tenecteplase is an alternative to alteplase for emergency treatment of acute ischemic stroke. However, limited data are available comparing their clinical effectiveness in routine clinical practice. Objective To compare short-te…

Atrial Fibrillation and Retinal Stroke Open

Jay B. Lusk, Vinit Nalawade, Lauren E. Wilson, Ailin Song, Matthew Schrag , et al. · 2025

Importance Atrial fibrillation (AF) is the most common, chronic, cardiac arrythmia in older US adults. It is not known whether AF is independently associated with increased risk of retinal stroke (central retinal artery occlusion), a subty…

Statin therapy in ischemic stroke patients with atrial fibrillation: Efficacy and safety outcomes Open

Michele Marvardi, Maurizio Paciaroni, Valeria Caso, Michele Marvardi, Mario Ferrante , et al. · 2025

Introduction: The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as a risk factor for both …

Considerations Regarding Association of Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy Open

Jay B. Lusk, Brian Mac Grory, Li Fan · 2024

To the Editor We read with interest the article by Hathaway et al and applaud the effort to investigate safety signals of semaglutide. We were, however, concerned that the methods used may suffer from bias.

Interdisciplinary Engagement In Neurocardiology: A Key Opportunity Open

Jay B. Lusk, Brian Mac Grory, Kevin N. Sheth, Deepak L. Bhatt · 2024

Predictors of Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection Open

Daniel Mandel, Liqi Shu, Christopher Chang, N JACK, Christopher R. Leon Guerrero , et al. · 2024

Objective Patients with cervical artery dissection (CAD) are at increased ischemic stroke risk. We aimed to identify characteristics that are associated with increased risk of ischemic stroke following initial presentation of CAD and to ev…

Statin Therapy in Ischemic Stroke Patients with Atrial Fibrillation: Efficacy and Safety Outcomes Open

Michele Marvardi, Mario Ferrante, Maurizio Paciaroni, Azmil H. Abdul‐Rahim, Georgios Tsivgoulis , et al. · 2024

Background The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as a risk factor for both isc…

Early REperfusion therapy with intravenous alteplase for recovery of VISION in acute central retinal artery occlusion (REVISION): Study protocol of a phase III trial Open

Sven Poli, Carsten Grohmann, D. Wénzel, Khouloud Poli, Johannes Tünnerhoff , et al. · 2024

Rationale: Meta-analyses of case series of non-arteritic central retinal artery occlusion (CRAO) indicate beneficial effects of intravenous thrombolysis when initiated early after symptom onset. Randomized data are lacking to address this …

Time to Anticoagulation Reversal and Outcomes After Intracerebral Hemorrhage Open

Kevin N. Sheth, Nicole Solomon, Brooke Alhanti, Steven R. Messé, Ying Xian , et al. · 2024

Importance Intracerebral hemorrhage (ICH) is the deadliest stroke subtype, and mortality rates are especially high in anticoagulation-associated ICH. Recently, specific anticoagulation reversal strategies have been developed, but it is not…

Trends in Stroke Thrombolysis Care Metrics and Outcomes by Race and Ethnicity, 2003-2021 Open

Shumei Man, Nicole Solomon, Brian Mac Grory, Brooke Alhanti, Jeffrey L. Saver , et al. · 2024

Importance Understanding is needed of racial and ethnic–specific trends in care quality and outcomes associated with the US nationwide quality initiative Target: Stroke (TS) in targeting thrombolysis treatment for acute ischemic stroke. Ob…

Algorithm for Rapid Exclusion of Clinically Relevant Plasma Levels of Direct Oral Anticoagulants in Patients Using the DOAC Dipstick: An Expert Consensus Paper Open

Job Harenberg, Robert C. Gosselin, Adam Cuker, Cecilia Becattini, Ingrid Pabinger , et al. · 2024

With the widespread use of direct oral anticoagulants (DOACs), there is an urgent need for a rapid assay to exclude clinically relevant plasma levels. Accurate and rapid determination of DOAC levels would guide medical decision-making to (…

Management of Incomplete Microcirculatory Reperfusion After Endovascular Thrombectomy: Focus on Inhibition of the Glycoprotein IIb/IIIa Receptor Pathway Open

Neeharika Krothapalli, Thomas L. Ortel, Devin W. McBride, Adam de Havenon, Lauren Sansing , et al. · 2024

Endovascular thrombectomy (EVT) is one of the most effective therapies for acute ischemic stroke attributable to large‐vessel occlusion but, despite successful treatment, there remains a significant number of patients with disability. The …

COVID‐19 Infection Is Associated With Poor Outcomes in Patients With Intracerebral Hemorrhage Open

Daniela Renedo, Audrey C. Leasure, Rebecca Young, Cyprien Rivier, Brooke Alhanti , et al. · 2024

Background Patients with ischemic stroke and concomitant COVID‐19 infection have worse outcomes than those without this infection, but the impact of COVID‐19 on hemorrhagic stroke remains unclear. We aimed to assess if COVID‐19 worsens out…

The Impact of Atherosclerotic Burden on Vascular Outcomes in Patients with Stroke and Atrial Fibrillation: The ATHENA study Open

Andrea Galeazzo Rigutini, Andrea Galeazzo Rigutini, Maurizio Paciaroni, Virginia Cancelloni, Gregory Y.H. Lip , et al. · 2024

Introduction: Patients with ischemic stroke (IS) and atrial fibrillation (AF) face a higher risk of recurrent vascular events. This study evaluates the impact of atherosclerotic vascular disease burden across different vascular territories…

Atrial fibrillation as a novel risk factor for retinal stroke: A protocol for a population-based retrospective cohort study Open

Jay B. Lusk, Lauren E. Wilson, Vinit Nalwade, Ailin Song, Matthew Schrag , et al. · 2023

Central retinal artery occlusion (CRAO; retinal stroke or eye stroke) is an under-recognized, disabling form of acute ischemic stroke which causes severe visual loss in one eye. The classical risk factor for CRAO is ipsilateral carotid ste…

Apixaban versus Aspirin for Embolic Stroke of Undetermined Source Open

Tobias Geisler, Timea Keller, Peter Martus, Khouloud Poli, Lina María Serna‐Higuita , et al. · 2023

BACKGROUND: Rivaroxaban and dabigatran were not superior to aspirin in trials of patients with embolic stroke of undetermined source (ESUS). It is unknown whether apixaban is superior to aspirin in patients with ESUS and known risk factors…

National- and State-Level Trends in Medicare Hospice Beneficiaries for Stroke During 2013 to 2019 in the United States Open

Adam de Havenon, Lesli E. Skolarus, Brian Mac Grory, Aaron Bangad, Kevin N. Sheth , et al. · 2023

BACKGROUND: Stroke is the fifth leading cause of death in the United States, one of the leading contributors to Medicare cost, including through Medicare hospice benefits, and the rate of stroke mortality has been increasing since 2013. We…

Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial Open

Sven Poli, Joshua Mbroh, Jean‐Claude Baron, Aneesh B. Singhal, Daniel Strbian , et al. · 2023

Rationale: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs. Aims: P…

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