Brian Marples
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View article: Wide-Angle Lung Experiment Segmentation (WALES): Effective quantitative assessment of lung pathology in model systems
Wide-Angle Lung Experiment Segmentation (WALES): Effective quantitative assessment of lung pathology in model systems Open
For preclinical studies, the standard practice for evaluating lung injury usually involves an assessment of pulmonary histopathology by a certified pathologist. This is typically accomplished by light microscopy using a semiquantitative fo…
View article: Extracellular vesicle proteomics identify neutrophils as potential mediators of bladder radiotoxicity in prostate cancer
Extracellular vesicle proteomics identify neutrophils as potential mediators of bladder radiotoxicity in prostate cancer Open
View article: Cryoablation and Intratumoral Immunotherapy for Breast Cancer: A Future Path to Cost-Effective De-Escalation for Larger Tumors, Lymph Nodes and Metastatic Disease
Cryoablation and Intratumoral Immunotherapy for Breast Cancer: A Future Path to Cost-Effective De-Escalation for Larger Tumors, Lymph Nodes and Metastatic Disease Open
Cryoablation is a promising, cost-effective option to de-escalate surgical breast cancer morbidity, but presently is only suggested for breast cancers < 1.5 cm, in select candidates. Breast cancer cryoablation is not a reliably covered pro…
View article: Supplementary Table S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S3 shows bivariate associations of patient, cancer, and treatment factors with hematuria
View article: Supplementary Table S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S1 lists the SNVs included in the PRS
View article: Supplementary Figure S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Figure S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Figure S1 shows principal components analysis of participants from the RGC and REQUITE+URWCI cohorts.
View article: Supplementary Figure S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Figure S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Figure S3 shows a Manhattan plot from the GWAS
View article: Supplementary Table S4 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S4 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S4 shows a multivariable model of hematuria including the PRS, rare variants, and clinical factors
View article: Supplementary Figure S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Figure S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Figure S2 shows a quantile-quantile plot from the GWAS
View article: Data from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Data from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Background:Late bladder toxicity is a concern for patients receiving prostate cancer radiotherapy and negatively affects survivors. Few risk factors are known beyond the radiation dose and volume of bladder exposed. A polygenic risk score …
View article: Supplementary Table S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer
Supplementary Table S2 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer Open
Table S2 shows the association of known prognostic factors with time to biochemical recurrence
View article: Mathematical modeling in radiotherapy for cancer: a comprehensive narrative review
Mathematical modeling in radiotherapy for cancer: a comprehensive narrative review Open
View article: Kdm3b Regulates Post Radiation Fibrotic Responses in Prostate Stroma Via M6a Modification of Lox
Kdm3b Regulates Post Radiation Fibrotic Responses in Prostate Stroma Via M6a Modification of Lox Open
View article: Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice
Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice Open
Patients receiving cranial radiation therapy experience tissue damage and cognitive deficits that severely decrease their quality of life. Experiments in rodent models show that these adverse neurological effects are in part due to functio…
View article: Ultralow-dose irradiation enables engraftment and intravital tracking of disease initiating niches in clonal hematopoiesis
Ultralow-dose irradiation enables engraftment and intravital tracking of disease initiating niches in clonal hematopoiesis Open
Recent advances in imaging suggested that spatial organization of hematopoietic cells in their bone marrow microenvironment (niche) regulates cell expansion, governing progression, and leukemic transformation of hematological clonal disord…
View article: Generating and monitoring mild hyperthermia using a ring array ultrasound transducer
Generating and monitoring mild hyperthermia using a ring array ultrasound transducer Open
A ring array US transducer can noninvasively generate and monitor MHTh, overcoming many limitations of current clinical systems. The closed geometry of the transducer is optimal for acoustic focusing and UST-guidance allows for improved ab…
View article: Ultralow-dose irradiation enables engraftment and intravital tracking of disease initiating niches in clonal hematopoiesis
Ultralow-dose irradiation enables engraftment and intravital tracking of disease initiating niches in clonal hematopoiesis Open
Recent advances in imaging suggested that spatial organization of hematopoietic cells in their bone marrow microenvironment (niche) regulates cell expansion, governing progression, and leukemic transformation of hematological clonal disord…
View article: Cranial irradiation disrupts homeostatic microglial dynamic behavior
Cranial irradiation disrupts homeostatic microglial dynamic behavior Open
Cranial irradiation causes cognitive deficits that are in part mediated by microglia, the resident immune cells of the brain. Microglia are highly reactive, exhibiting changes in shape and morphology depending on the function they are perf…
View article: A new strategy for Alzheimer’s disease: low‐dose combination of radiotherapy and pharmacological epigenetic perturbation
A new strategy for Alzheimer’s disease: low‐dose combination of radiotherapy and pharmacological epigenetic perturbation Open
Background Most Alzheimer’s disease (AD) drug discovery studies focus exclusively on one specific target. This approach has to date shown limited success in AD, mainly because this complex disease is multifactorial and involves numerous pa…
View article: KDM3B Single-Nucleotide Polymorphisms Impact Radiation Therapy Toxicity Through Circular RNA-Mediated KDM3B Expression and Inflammatory Responses
KDM3B Single-Nucleotide Polymorphisms Impact Radiation Therapy Toxicity Through Circular RNA-Mediated KDM3B Expression and Inflammatory Responses Open
View article: Effects of photobiomodulation and caffeine treatment on acute kidney injury in a hypoxic ischemic neonatal rat model
Effects of photobiomodulation and caffeine treatment on acute kidney injury in a hypoxic ischemic neonatal rat model Open
Hypoxic ischemic encephalopathy (HIE) occurs in 2–5/1000 births, with acute kidney injury (AKI) occurring in 40%. AKI increases morbidity and mortality. Caffeine, an adenosine receptor antagonist, and photobiomodulation (PBM), working on c…
View article: Radiation nephropathy: Mechanisms of injury and recovery in a murine model
Radiation nephropathy: Mechanisms of injury and recovery in a murine model Open
View article: Investigating the Synergistic Potential of Low-Dose HDAC3 Inhibition and Radiotherapy in Alzheimer’s Disease Models
Investigating the Synergistic Potential of Low-Dose HDAC3 Inhibition and Radiotherapy in Alzheimer’s Disease Models Open
We have previously shown that histone deacetylase (HDAC) inhibition and cranial radiotherapy (RT) independently improve molecular and behavioral Alzheimer’s disease (AD)-like phenotypes. In the present study, we investigate the synergistic…
View article: Supplementary Figure Legends from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses
Supplementary Figure Legends from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses Open
S1. VSV-hIFNβ treatment followed by RT caused S-phase cell cycle arrest of prostate cancer cells. S2. VSV treatment in combination with radiation therapy increases the GFP or Luciferase expression in vitro and in vivo. S3. C57BL/6 CD8 Re-c…
View article: Data from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses
Data from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses Open
Vesicular stomatitis virus (VSV) expressing IFNβ induces apoptosis in multiple tumor models while maintaining an excellent safety profile. VSV-IFNβ is oncoselective due to permissive replication in cells with an altered IFN pathway. The hu…
View article: Supplementary Figures from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses
Supplementary Figures from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses Open
Supplementary Figures 1-3
View article: Supplementary Figures from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses
Supplementary Figures from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses Open
Supplementary Figures 1-3
View article: Data from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses
Data from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses Open
Vesicular stomatitis virus (VSV) expressing IFNβ induces apoptosis in multiple tumor models while maintaining an excellent safety profile. VSV-IFNβ is oncoselective due to permissive replication in cells with an altered IFN pathway. The hu…
View article: Supplementary Figure Legends from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses
Supplementary Figure Legends from Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing IFNβ, Resulting in Pronounced Antitumor Systemic Immune Responses Open
S1. VSV-hIFNβ treatment followed by RT caused S-phase cell cycle arrest of prostate cancer cells. S2. VSV treatment in combination with radiation therapy increases the GFP or Luciferase expression in vitro and in vivo. S3. C57BL/6 CD8 Re-c…
View article: Modeling normal bladder injury after radiation therapy
Modeling normal bladder injury after radiation therapy Open
Despite the differences in functional endpoints, recent findings indicate a commonality between bladder late effects and the work in kidney pioneered by Dr. John Moulder. We offer evidence that targeting the RAS pathway may provide a targe…