James B. Mitchell
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View article: Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair
Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair Open
Aims: Pancreatic ductal adenocarcinomas (PDACs) form hypovascular and hypoxic tumors, which are difficult to treat with current chemotherapy regimens. Gemcitabine (GEM) is often used as a first-line treatment for PDACs but has issues with …
View article: Supplementary Figure S4 from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384
Supplementary Figure S4 from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384 Open
Supplementary Figure S4. The effects of PF-05212384 (10μM) on UMSCC46 radiation induced DNA damage repair.
View article: Figure S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Figure S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Immunoblotting of SDHA and SDHB expression in three pancreatic tumors.
View article: Table S2 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Table S2 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Lactate to pyruvate ratio and kpyr-lac of individual PDAC tumors in hyperpolarized 13C MRI study.
View article: Data from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
Data from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer Open
Purpose: Phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway activation is often associated with altered expression or mutations of PIK3CA, TP53/p73, PTEN, and TGF-β receptors (TGFBR) in head and neck squamous cel…
View article: Supplemental Table 1 from SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes <i>FADD</i> and <i>BIRC2</i>
Supplemental Table 1 from SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes <i>FADD</i> and <i>BIRC2</i> Open
HNSCC cell lines
View article: Supplementary Figure 7 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
Supplementary Figure 7 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer Open
PDF file - 820K, Effects on p21 in wt and mtTP53 xenografts.
View article: Supplemental Table 1 from SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes <i>FADD</i> and <i>BIRC2</i>
Supplemental Table 1 from SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes <i>FADD</i> and <i>BIRC2</i> Open
HNSCC cell lines
View article: Supplementary Figure 1 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
Supplementary Figure 1 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer Open
PDF file - 3324K, Effects on PI3K-mTOR, TP53 and p73.
View article: Suplementary Methods from SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes <i>FADD</i> and <i>BIRC2</i>
Suplementary Methods from SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes <i>FADD</i> and <i>BIRC2</i> Open
Supplementary Methods
View article: Data from <i>In vitro</i> and <i>In vivo</i> Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor, AZD7762
Data from <i>In vitro</i> and <i>In vivo</i> Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor, AZD7762 Open
Purpose: Inhibition of checkpoint kinase 1 has been shown to enhance the cytotoxicity of DNA-damaging targeted chemotherapy through cell cycle checkpoint abrogation and impaired DNA damage repair. A novel checkpoint kinase 1/2 inhibitor, A…
View article: Supplementary Figure S2 from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384
Supplementary Figure S2 from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384 Open
Supplementary Figure S2. Flow cytometry profiles of UMSCC1, UMSCC46, 1522, and plateau-phase UMSCC1 cells treated with PF-05212384 (10 μM) for 24 hr with associated 24 hr DMSO (10 μM) controls.
View article: Supplemental Figures from Hyperpolarized [1-<sup>13</sup>C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer <i>In Vivo</i> Predicts Efficacy of Targeting the Warburg Effect
Supplemental Figures from Hyperpolarized [1-<sup>13</sup>C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer <i>In Vivo</i> Predicts Efficacy of Targeting the Warburg Effect Open
Supplemental Figures
View article: Supplementary Figure S3 from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384
Supplementary Figure S3 from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384 Open
Supplementary Figure S3. The effects of PF-05212384 on the phosphorylation of the PI3K/mTOR downstream targets S6 and 4EBP1 as a function of PF-05212384 (10 μM) treatment time following irradiation (7.5 Gy) for exponentially growing A) UMS…
View article: Supplementary Figure 3 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
Supplementary Figure 3 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer Open
PDF file - 107K, Photomicrographs of Effects of PF502 and pifithrin.
View article: Supplementary Table 3 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
Supplementary Table 3 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer Open
PDF file - 184K, TGFBR mutations.
View article: Figure S2 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Figure S2 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Immunostaining of hypoxia marker pimonidazole of three pancreatic tumors. Representative pictures of whole tumor area were shown.
View article: Supplemental Figures from SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes <i>FADD</i> and <i>BIRC2</i>
Supplemental Figures from SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes <i>FADD</i> and <i>BIRC2</i> Open
Supplemental Figures and Legends: Supplemental Figure 1. Effect of Birc2, Birc3, and FADD knockdown in UM-SCC-1 and UM-SCC-11A; Supplemental Figure 2. Summary of DNA cell cycle cytofluorometry in UM-SCC lines; Supplemental Figure 3. Effect…
View article: Supplemental materials and methods from Hyperpolarized [1-<sup>13</sup>C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer <i>In Vivo</i> Predicts Efficacy of Targeting the Warburg Effect
Supplemental materials and methods from Hyperpolarized [1-<sup>13</sup>C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer <i>In Vivo</i> Predicts Efficacy of Targeting the Warburg Effect Open
Supplemental materials and methods
View article: Supplementary Method Legends from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384
Supplementary Method Legends from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384 Open
Supplementary Table S1. Senescence pathway directed RT-PCR genomic expression analysis of UMSCC1 cells treated with 24 hour PF-05212384 (10 �M) or DMSO (10 �M) followed by irradiation (10 Gy) or mock irradiation.
View article: Figure S3 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Figure S3 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Plots of tumor growth delay vs HF10; pO2; lac/pyr
View article: Supplemental Figure Legends from Hyperpolarized [1-<sup>13</sup>C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer <i>In Vivo</i> Predicts Efficacy of Targeting the Warburg Effect
Supplemental Figure Legends from Hyperpolarized [1-<sup>13</sup>C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer <i>In Vivo</i> Predicts Efficacy of Targeting the Warburg Effect Open
Supplemental Figure Legends
View article: Supplemental Figure Legends from Hyperpolarized [1-<sup>13</sup>C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer <i>In Vivo</i> Predicts Efficacy of Targeting the Warburg Effect
Supplemental Figure Legends from Hyperpolarized [1-<sup>13</sup>C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer <i>In Vivo</i> Predicts Efficacy of Targeting the Warburg Effect Open
Supplemental Figure Legends
View article: Supplementary Figure S6 from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384
Supplementary Figure S6 from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384 Open
Supplementary Figure S6. Heat map of individual mRNA absolute Ct obtained from senescence pathway directed RT-PCR of UMSCC1 cells treated with 24 hour PF-05212384 (10 μM) or DMSO (10 μM) followed by irradiation (10 Gy) or mock irradiatio…
View article: Supplementary Figure 5 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
Supplementary Figure 5 from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer Open
PDF file - 1957K, Treatment in UM-SCC xenograft and Tgfbr1/Pten KO mice.
View article: CCR Translation for This Article from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
CCR Translation for This Article from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer Open
CCR Translation for This Article from PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer
View article: Table S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Table S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Median pO2 and HF10 of individual PDAC tumors in EPR oxygen imaging study.
View article: Table S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Table S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Median pO2 and HF10 of individual PDAC tumors in EPR oxygen imaging study.
View article: Supplementary Figure S5 from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384
Supplementary Figure S5 from Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384 Open
Supplementary Figure S5. Representative western blot of two independent experiments characterizing the impact PF-05212384 has on ATM and DNA-PKc autophosphorylation and total protein levels as a function PF-05212384 (10 μM) treatment time …