Explanipedia

Depression, Obstructive Sleep Apnea and Cognitive Impairment (DOC) Screen Completion Time Reflects Executive Function, Speed of Processing and Fluency Open

Sajeevan Sujanthan, Alisia Southwell, Tera Armel, Elaine Xing, Arunima Kapoor , et al. · 2024

Background: The depression, obstructive sleep apnea and cognitive impairment (DOC) screen assesses three post-stroke comorbidities, but additional information may be gained from the time to complete the screen. Cognitive screening completi…

The relationship between the morningness-eveningness questionnaire and incident cancer: A historical clinical cohort study Open

Tetyana Kendzerska, Brian J. Murray, David R. Colelli, Gio R. Dela Cruz, Andrea S. Gershon , et al. · 2024

The U-shaped curve may reflect deviations from a standard circadian tendency, which may stress biological systems and influence malignancy risk.

Cannabinoid Use and Obstructive Sleep Apnea: A Retrospective Cohort Study Open

Matthew Veitch, Sean Jairam, Patrick Gurges, Elliott Cohen, Tetyana Kendzerska , et al. · 2024

Background: Obstructive sleep apnea (OSA) is a sleep disorder with no widely accepted pharmacological therapy. Cannabinoids have been suggested to reduce OSA severity in small human studies. The purpose of this retrospective cohort study w…

Obstructive sleep apnea in those with idiopathic intracranial hypertension undergoing diagnostic in-laboratory polysomnography Open

Mark Youssef, Arun Sundaram, Matthew Veitch, Arpsima Aziz, Patrick Gurges , et al. · 2024

IIH treated with acetazolamide was not an independent risk factor for OSA presence or severity. The presence of IIH treated with acetazolamide likely does not warrant routine screening for OSA, but related risk factors may identify appropr…

Sleep selectively and durably enhances real-world sequence memory Open

Nicholas B. Diamond, Sharon Simpson, Daniel Pérez, Brian J. Murray, Stuart Fogel , et al. · 2024

Sleep is thought to play a critical role in the retention of episodic memories. Yet it remains unclear whether and how sleep actively transforms memory for specific experiences. More generally, little is known about sleep’s effects on memo…

Machine-learning assisted swallowing assessment: a deep learning-based quality improvement tool to screen for post-stroke dysphagia Open

Rami Saab, Arjun Balachandar, Hamza Mahdi, Eptehal Nashnoush, Lucas X. Perri , et al. · 2023

Introduction Post-stroke dysphagia is common and associated with significant morbidity and mortality, rendering bedside screening of significant clinical importance. Using voice as a biomarker coupled with deep learning has the potential t…

Strengthening oropharyngeal muscles as an approach to treat post‐stroke obstructive sleep apnea: A feasibility randomised controlled trial Open

Reeman Marzouqah, Laavanya Dharmakulaseelan, David R. Colelli, C. J. Lindo, Yakdehikandage S. Costa , et al. · 2023

Summary This study aimed to determine the feasibility of a randomised controlled trial (RCT) evaluating oropharyngeal exercise (OPE) intervention as an alternative therapy for obstructive sleep apnea (OSA) in patients with stroke or transi…

Sex Differences in Obstructive Sleep Apnea after Stroke Open

Laavanya Dharmakulaseelan, Sandra E. Black, Richard H. Swartz, Brian J. Murray, Mark I. Boulos · 2023

Background and Objectives: Obstructive sleep apnea (OSA) is prevalent after stroke and associated with recurrent stroke, prolonged hospitalization, and decreased functional recovery. Sex differences in post-stroke OSA remain underexplored.…

The Importance of Sleep for Successful Neurorehabilitation after Stroke Open

Cristina Frange, Brian J. Murray, Fernando Morgadinho Santos Coelho · 2023

Sleep has important clinical implications for neurorehabilitation after stroke. We aimed to systematically explore sleep (including naps) as an essential factor in the neurorehabilitation of patients after stroke. After titles and abstract…

Incidental Detection of Anti-IgLON5: A Diagnostic and Therapeutic Dilemma Open

Samir Alkabie, Brian J. Murray, Adrian Budhram · 2023

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Impact of sleep chronotype on in‐laboratory polysomnography parameters Open

David R. Colelli, Gio R. Dela Cruz, Tetyana Kendzerska, Brian J. Murray, Mark I. Boulos · 2023

Summary Morningness–eveningness preference, also known as chronotype, is the tendency for a person to sleep during certain hours of the day and is broadly categorised into morning and evening types. In‐laboratory polysomnography (iPSG) is …

Polysomnographic Assessment of Sleep Disturbances in Cancer Development Open

Tetyana Kendzerska, Brian J. Murray, Andrea S. Gershon, Marcus Povitz, Daniel I. McIsaac , et al. · 2023

DOC screen completion time reflects executive function, speed of processing and fluency in an observational cohort study Open

Alisia Southwell, Sajeevan Sujanthan, Tera Armel, Elaine Xing, Arunima Kapoor , et al. · 2023

Background The DOC screen was developed to identify Depression, Obstructive sleep apnea, and Cognitive impairment (“DOC” comorbidities) after stroke. Each component has its own score, but additional information may be gained from the time …

Language discordance as a marker of disparities in cerebrovascular risk and stroke outcomes: A multi-center Canadian study Open

Ryan T. Muir, Arunima Kapoor, Megan L. Cayley, Michelle N. Sicard, Karen Lien , et al. · 2023

Factors Associated With Sleep Disturbance Amongst Youth With Bipolar Disorder. Open

Jessica Barton, Megan Mio, Vanessa Timmins, Rachel Mitchell, Brian J. Murray , et al. · 2022

Converging with data from adults, present findings indicate greater sleep disturbance among youth with BD versus HC. Also convergent with adults with BD, mood disturbance, whether depression severity or emotional lability, comprised the pr…

Relationship between gastroesophageal reflux disease and objective sleep quality Open

Patrick Gurges, Brian J. Murray, Mark I. Boulos · 2022

Gurges P, Murray BJ, Boulos MI. Relationship between gastroesophageal reflux disease and objective sleep quality. J Clin Sleep Med. 2022;18(12):2731-2738.

Incidental Findings Among Youth Participating in Multimodal Imaging Research: Characteristics of Findings and Description of a Management Approach Open

Jessica Roane, Megan Mio, Jacqueline Viner, Ariel Bettridge, Chris Heyn , et al. · 2022

Research imaging in healthy and clinical youth populations yields incidental findings that require a management strategy. Our primary objective was to document the frequency and nature of incidental findings within a research group integra…

Laxatives are Associated with Poorer Polysomnography-derived Sleep Quality Open

Yakdehikandage S. Costa, Brian J. Murray, Mark I. Boulos · 2022

Objective: To characterize 1) the relationship between laxative use and objective sleep metrics, and 2) the relationship between laxative use and self-reported insomnia symptoms in a convenience sample of middle-aged/elderly patients who c…

Language Discordance as a Marker of Disparities in Cerebrovascular Risk and Stroke Outcomes: A Multi-Center Prospective Canadian Study Open

Ryan T. Muir, Arunima Kapoor, Megan L. Cayley, Michelle N. Sicard, Karen Lien , et al. · 2022

Polysomnographic Markers of Obstructive Sleep Apnea Severity and Cancer-related Mortality: A Large Retrospective Multicenter Clinical Cohort Study Open

Tetyana Kendzerska, Andrea S. Gershon, Marcus Povitz, Mark I. Boulos, Brian J. Murray , et al. · 2021

Rationale: The evidence for an association between cancer survival and obstructive sleep apnea (OSA) remains underexplored. Objectives: To evaluate an association between markers of OSA severity (respiratory disturbances, hyp…

Sleep Quality in Neuromyelitis Optica Spectrum Disorder: A Systematic Review Open

Arshia Eshtiaghi, David Eapen-John, Kirill Zaslavsky, Reza Vosoughi, Brian J. Murray , et al. · 2021

BACKGROUND: This review summarizes the literature on sleep quality in neuromyelitis optica spectrum disorder (NMOSD) and discusses these findings in the context of current knowledge of sleep physiology. METHODS: A literature search was per…

Ethnic and Immigrant Variations in the Time Trends of Dementia and Parkinsonism Open

Jessica J. Wong, Jeffrey C. Kwong, Karen Tu, Debra A. Butt, Andrew S. Wilton , et al. · 2021

Objective: We assessed long-term incidence and prevalence trends of dementia and parkinsonism across major ethnic and immigrant groups in Ontario. Methods: Linking administrative databases, we established two cohorts (dementia 2001–2014 an…

Obstructive Sleep Apnea and Incident Cancer: A Large Retrospective Multicenter Clinical Cohort Study Open

Tetyana Kendzerska, Marcus Povitz, Richard Leung, Mark I. Boulos, Daniel I. McIsaac , et al. · 2020

Background: To examine the association between the severity of obstructive sleep apnea (OSA) and nocturnal hypoxemia with incident cancer. Methods: This was a multicenter retrospective clinical cohort study using linked clinical and provin…

ePS3.05 A neutrophilic inflammation-derived marker of disease Open

Brian J. Murray, Matthew S. Twigg, Simon Brockbank, Philip Lowry, Pat Fitzgerald , et al. · 2020

Obstructive Sleep Apnea and Incident Cancer: A Large Historical Multicenter Clinical Cohort Study Open

Tetyana Kendzerska, Marcus Povitz, Richard Leung, Mark I. Boulos, Daniel I. McIsaac , et al. · 2020

Embolic Stroke of Undetermined Source and Sleep Disorders Open

Laavanya Dharmakulaseelan, Nathan Chan-Smyth, Sandra E. Black, Richard H. Swartz, Brian J. Murray , et al. · 2020

Background and Purpose— Compared with other causes of ischemic stroke, the mechanism of action of embolic stroke of undetermined source (ESUS) remains unclear, with previous literature suggesting that ESUS may be due to an undetected cardi…

Actigraphic detection of periodic limb movements: development and validation of a potential device-independent algorithm. A proof of concept study Open

Yashodhan Athavale, Sridhar Krishnan, Afsaneh Raissi, Nardin Kirolos, Trevor Jairam , et al. · 2019

Study Objectives We propose a unique device-independent approach to analyze long-term actigraphy signals that can accurately quantify the severity of periodic limb movements in sleep (PLMS). Methods We analyzed 6–8 hr of bilateral ankle ac…

Depressive symptoms, sleep patterns, and physical activity in adolescents with narcolepsy Open

Arpita Parmar, E. Ann Yeh, Daphne J. Korczak, Shelly K. Weiss, Zihang Lu , et al. · 2019

Study Objectives To evaluate the association between depressive symptoms, sleep patterns (duration and quality), excessive daytime sleepiness (EDS), and physical activity (PA) in adolescents with narcolepsy. Methods This cross-sectional st…

Time Trends of the Incidence, Prevalence, and Mortality of Parkinsonism Open

Jessica J. Wong, Jeffrey C. Kwong, Karen Tu, Debra A. Butt, Ray Copes , et al. · 2019

Objectives: We assessed trends in the incidence, prevalence, and post-diagnosis mortality of parkinsonism in Ontario, Canada over 18 years. We also explored the influence of a range of risk factors for brain health on the trend of incident…

Family functioning among adolescents with narcolepsy Open

Arpita Parmar, Eluen Ann Yeh, Daphne J. Korczak, Shelly K. Weiss, Zihang Lu , et al. · 2019

Background Narcolepsy is a sleep disorder with no cure with onset typically during adolescence. Caring for an adolescent with a lifelong medical condition can negatively impact family structure, cohesion, relationships, and overall functio…

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