Brian N. Finck
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View article: A Western Diet High in Phosphate Primes the Development of the CKD-Mineral Bone Disorder in an Alport Syndrome Model
A Western Diet High in Phosphate Primes the Development of the CKD-Mineral Bone Disorder in an Alport Syndrome Model Open
Background: Chronic kidney disease – mineral bone disorder (CKD-MBD) is a syndrome that contributes to cardiovascular mortality. We have shown that CKD decreases cardiac mitochondrial function independent of vascular disease and prior to c…
View article: Inhibition of Adipocyte Lipolysis Reduces Liver Injury in a Mouse Model of Ischemia Reperfusion Injury
Inhibition of Adipocyte Lipolysis Reduces Liver Injury in a Mouse Model of Ischemia Reperfusion Injury Open
These data suggest that targeting adipocyte lipolysis may represent a novel therapeutic approach in the prevention of hepatic IRI, which could improve patient and graft outcomes following liver transplantation.
View article: Myocardial lipin1 protects the heart against ischemic injury by preserving lipid homeostasis
Myocardial lipin1 protects the heart against ischemic injury by preserving lipid homeostasis Open
Impaired cardiac lipid metabolism has been reported to cause heart failure. Lipin1, a multifunctional protein, is a phosphatidate phosphatase that generates diacylglycerol from phosphatidic acid and a transcriptional cofactor that regulate…
View article: Whole body MondoA deletion protects against diet-induced obesity through uncontrolled multi-organ substrate utilization and futile cycling
Whole body MondoA deletion protects against diet-induced obesity through uncontrolled multi-organ substrate utilization and futile cycling Open
Objective Delineating the nodal control points that maintain whole-body energy homeostasis is critical for understanding potential treatments of obesity and cardiometabolic diseases. The nutrient-sensing transcription factor MondoA is a re…
View article: Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice
Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice Open
Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme and a central factor in energy metabolism. Nicotinamide phosphoribosyltransferase (NAMPT) maintains the cellular NAD+ pool by synthesizing the NAD+ precursor, nicotinamide mononu…
View article: Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice
Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice Open
Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were …
View article: Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer
Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer Open
Liver cancer is a leading cause of cancer-related death world-wide in part due to the shortage of effective therapies, and MYC overexpression defines an aggressive and especially difficult to treat subset of patients. Given MYC’s ability t…
View article: At last: the mitochondrial pyruvate carrier structure revealed!
At last: the mitochondrial pyruvate carrier structure revealed! Open
Mitochondrial pyruvate carrier (MPC) inhibitors have shown promise as therapeutics for treating several chronic diseases. However, the structure of MPC and the molecular mechanisms by which it interacts with inhibitors have remained unclea…
View article: Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation and inflammation in MASLD
Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation and inflammation in MASLD Open
Kupffer cells (KCs) are the tissue-resident macrophage of the liver where they serve a critical role in maintaining liver tissue homeostasis and as a filter for circulation. The composition of liver macrophages changes during metabolic dys…
View article: Assays to enhance metabolic phenotyping in the kidney
Assays to enhance metabolic phenotyping in the kidney Open
We show significant metabolic differences between both primary and immortalized cells, and among primary cells with different durations in cell culture. In addition, 3 H-palmitate oxidation in tissue ex vivo is described as a method novel …
View article: A Critical Role for the Mitochondrial Pyruvate Carrier in Hepatic Stellate Cell Activation
A Critical Role for the Mitochondrial Pyruvate Carrier in Hepatic Stellate Cell Activation Open
These data suggest that MPC inhibition modulates HSC metabolism to attenuate activation and illuminate mechanisms by which MPC inhibitors could prove therapeutically beneficial for treating MASH.
View article: Lipin-1 restrains macrophage lipid synthesis to promote inflammation resolution
Lipin-1 restrains macrophage lipid synthesis to promote inflammation resolution Open
Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. The lipid metabolic state of macrophages influences their function and polarization, which is crucial to the resolution of inflammation. The cont…
View article: Beyond ketosis: the search for the mechanism underlying SGLT2-inhibitor benefit continues
Beyond ketosis: the search for the mechanism underlying SGLT2-inhibitor benefit continues Open
Despite the impressive clinical benefits and widespread adoption of sodium glucose cotransporter 2 inhibitors (SGLT2i) to treat all classes of heart failure, their cardiovascular mechanisms of action are poorly understood. Proposed mechani…
View article: Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier
Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier Open
Inhibition of mitochondrial pyruvate transport via the mitochondrial pyruvate carrier (MPC) has shown beneficial effects in treating metabolic diseases, certain cancers, various forms of neurodegeneration, and hair loss. These benefits ari…
View article: Lipin1 as a therapeutic target for respiratory insufficiency of duchenne muscular dystrophy
Lipin1 as a therapeutic target for respiratory insufficiency of duchenne muscular dystrophy Open
In Duchenne muscular dystrophy (DMD), diaphragm muscle dysfunction results in respiratory insufficiency which is a leading cause of death in patients. Mutations to the dystrophin gene result in myocyte membrane instability, contributing to…
View article: Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice
Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice Open
Dysfunctional adipose tissue is believed to promote the development of hepatic steatosis and systemic insulin resistance, but many of the mechanisms involved are still unclear. Lipin 1 catalyzes the conversion of phosphatidic acid to diacy…
View article: Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock
Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock Open
Organisms integrate circadian and metabolic signals to optimize substrate selection to survive starvation, yet precisely how this occurs is unclear. Here, we show that hepatocyte Period 1 (Per1) is selectively induced during fasting, and m…
View article: Obese mice have decreased uterine contractility and altered energy metabolism in the uterus at term gestation
Obese mice have decreased uterine contractility and altered energy metabolism in the uterus at term gestation Open
Over 35% of reproductive-age women in the USA have obesity, putting them at increased risk for numerous obstetric complications due to abnormal labor. While the association between maternal obesity and abnormal labor has been well document…
View article: Adipocyte-specific inactivation of NAMPT, a key NAD<sup>+</sup> biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging
Adipocyte-specific inactivation of NAMPT, a key NAD<sup>+</sup> biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging Open
Defective NAD + metabolism is associated with aging and age-associated metabolic diseases. In the present study, we provided in-depth metabolic assessments in female mice with adipocyte-specific inactivation of a key NAD + biosynthetic enz…
View article: Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model
Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model Open
Sarcopenia burdens the older population through loss of muscle energy and mass, yet treatments to functionally rescue both parameters are lacking. The glucocorticoid prednisone remodels muscle metabolism on the basis of frequency of intake…
View article: In chronic kidney disease altered cardiac metabolism precedes cardiac hypertrophy
In chronic kidney disease altered cardiac metabolism precedes cardiac hypertrophy Open
Heart disease is an important morbidity of chronic kidney disease (CKD). Hypertension, vascular stiffness, and vascular calcification all contribute to cardiac pathophysiology. However, cardiac function in CKD devoid of vascular disease ha…
View article: Disruption of hepatic mitochondrial pyruvate and amino acid metabolism impairs gluconeogenesis and endurance exercise capacity in mice
Disruption of hepatic mitochondrial pyruvate and amino acid metabolism impairs gluconeogenesis and endurance exercise capacity in mice Open
Martino and colleagues examined the effects of inhibiting hepatic gluconeogenesis on exercise performance and systemic metabolism during treadmill exercise in mice. Combined inhibition of gluconeogenesis from lactate/pyruvate and alanine i…