Brian N. Mathur
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The Human Claustrum Activates Across Multiple Cognitive Control Tasks Open
Cognitive control, the ability to manage information during purposeful actions, is crucial for everyday functioning and can become impaired in a variety of neuropsychiatric disorders. The claustrum, a subcortical brain structure with wides…
Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum Open
Through its widespread reciprocal connections with the cerebral cortex, the claustrum is implicated in sleep and waking cortical network states. Yet, basic knowledge of neuromodulation in this structure is lacking. The claustrum is richly …
View article: Dopamine Receptor 1 Specific CRISPRa Mice Exhibit Disrupted Behaviors and Striatal Baseline Cellular Activity
Dopamine Receptor 1 Specific CRISPRa Mice Exhibit Disrupted Behaviors and Striatal Baseline Cellular Activity Open
The two main cell types in the striatum, dopamine receptor 1 and adenosine receptor 2a spiny projection neurons (D1-SPNs and A2A-SPNs), have distinct roles in regulating motor- and reward-related behaviors. Cre-selective CRISPR-dCas9 syste…
Perineuronal Net and Inhibitory Synapse Remodeling on Striatal Fast-spiking Interneurons by Chronic Alcohol Exposure Open
Alcohol use disorder is characterized by persistent drinking in the face of negative consequences. Such inflexible drinking requires dorsolateral striatum fast-spiking interneurons, which comprise roughly 1% of all striatal neurons. How ch…
The human claustrum initiates networks for externally and internally driven task demands Open
Cognitive control is believed to arise from interactions among multiple brain networks depending on task demands. Although several debilitating neuropsychiatric disorders are characterized by cognitive network dysfunction, the neural circu…
View article: Dopamine receptor 1 specific CRISPRa mice exhibit disrupted behaviors and striatal baseline cellular activity
Dopamine receptor 1 specific CRISPRa mice exhibit disrupted behaviors and striatal baseline cellular activity Open
The two main cell types in the striatum, dopamine receptor 1 and adenosine receptor 2a spiny projection neurons (D1-SPNs and A2A-SPNs), have distinct roles in regulating motor- and reward-related behaviors. Cre-selective CRISPR-dCas9 syste…
The human claustrum activates across multiple cognitive tasks Open
Cognitive control, the ability to manage information during purposeful actions, is crucial for everyday functioning and can become impaired in a variety of neuropsychiatric disorders. The claustrum, a subcortical brain structure, has recen…
Rapid modeling of an ultra-rare epilepsy variant in wild-type mice by in utero prime editing Open
Generating animal models for individual patients within clinically-useful timeframes holds great potential toward enabling personalized medicine approaches for genetic epilepsies. The ability to rapidly incorporate patient-specific genomic…
Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain Open
Summary Aberrant cognitive network activity and cognitive deficits are established features of chronic pain. However, the nature of cognitive network alterations associated with chronic pain and their underlying mechanisms require elucidat…
The rostral intralaminar nuclear complex of the thalamus supports striatally mediated action reinforcement Open
The dorsal striatum (DS) mediates the selection of actions for reward acquisition necessary for survival. Striatal pathology contributes to several neuropsychiatric conditions, including aberrant selection of actions for specific rewards i…
Author response: The rostral intralaminar nuclear complex of the thalamus supports striatally mediated action reinforcement Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The dorsal striatum (D…
The mouse claustrum synaptically connects cortical network motifs Open
Spatially distant areas of the cerebral cortex coordinate their activity into networks that are integral to cognitive processing. A common structural motif of cortical networks is co-activation of frontal and posterior cortical regions. Th…
The rostral intralaminar nuclear complex of the thalamus supports striatally-mediated action reinforcement Open
The dorsal striatum (DS) mediates the selection of actions for reward acquisition necessary for survival. Striatal pathology contributes to several neuropsychiatric conditions, including aberrant selection of actions for specific rewards i…
The mouse claustrum synaptically connects cortical network motifs Open
Summary Spatially distant areas of cerebral cortex coordinate their activity into networks that are integral to cognitive processing. A common structural motif of cortical networks is co-activated frontal and posterior cortical regions. Kn…
View article: A role for the claustrum in cognitive control
A role for the claustrum in cognitive control Open
Early hypotheses of claustrum function were fueled by neuroanatomical data and suggested that the claustrum is involved in processes ranging from salience detection to multisensory integration for perceptual binding. While these hypotheses…
View article: Estradiol mediates stress-susceptibility in the male brain
Estradiol mediates stress-susceptibility in the male brain Open
In susceptible populations, stress is a major risk factor for the development of mental disorders, including depression. Estradiol, often considered a female hormone, is distributed in the male brain via aromatization of testosterone. The …
Models of psychedelic drug action: modulation of cortical-subcortical circuits Open
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have recaptured the imagination of both science and popular culture, and may have efficacy in treating a wide range of psychiatric disorders. Human and anima…
Psychedelics and Consciousness: Distinctions, Demarcations, and Opportunities Open
Psychedelic substances produce unusual and compelling changes in conscious experience that have prompted some to propose that psychedelics may provide unique insights explaining the nature of consciousness. At present, psychedelics, like o…
Rostral Intralaminar Thalamus Engagement in Cognition and Behavior Open
The thalamic rostral intralaminar nuclei (rILN) are a contiguous band of neurons that include the central medial, paracentral, and central lateral nuclei. The rILN differ from both thalamic relay nuclei, such as the lateral geniculate nucl…
Axo‐axonic synapses: Diversity in neural circuit function Open
The chemical synapse is the principal form of contact between neurons of the central nervous system. These synapses are typically configured as presynaptic axon terminations onto postsynaptic dendrites or somata, giving rise to axo‐dendrit…