Sacha B. Nelson
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View article: Spatio-temporal dynamics of lateral Na<sup>+</sup> diffusion in apical dendrites of mouse CA1 pyramidal neurons
Spatio-temporal dynamics of lateral Na<sup>+</sup> diffusion in apical dendrites of mouse CA1 pyramidal neurons Open
Sodium ions (Na + ) are major charge carriers mediating neuronal excitation and play a fundamental role in brain physiology. Glutamatergic synaptic activity is accompanied by large transient Na + increases, but the spatio-temporal dynamics…
View article: Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration
Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration Open
INTRODUCTION Neighborhood deprivation is associated with shorter survival, cognitive impairment and neurodegeneration in aging and Alzheimer’s disease. However, the association of neighborhood deprivation with disease progression in behavi…
View article: Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex
Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex Open
A critical phase of mammalian brain development takes place after birth. Neurons of the mouse neocortex undergo dramatic changes in their morphology, physiology, and synaptic connections during the first postnatal month, while properties o…
View article: Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex
Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex Open
A critical phase of mammalian brain development takes place after birth. Neurons of the mouse neocortex undergo dramatic changes in their morphology, physiology, and synaptic connections during the first postnatal month, while properties o…
View article: Theoretical Analysis of Multi-coding with Arbitrary Correlations Among the Codes
Theoretical Analysis of Multi-coding with Arbitrary Correlations Among the Codes Open
The use of non-orthogonal signals has several benefits over orthogonal signals in multi-coded communications. We provide a novel, theoretical study of non-orthogonal signaling to expand the applicability of these schemes. Motivated by a cl…
View article: Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex
Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex Open
A critical phase of mammalian brain development takes place after birth. Neurons of the mouse neocortex undergo dramatic changes in their morphology, physiology, and synaptic connections during the first postnatal month, while properties o…
View article: eLife Assessment: Rab10 inactivation promotes AMPAR insertion and spine enlargement during long-term potentiation
eLife Assessment: Rab10 inactivation promotes AMPAR insertion and spine enlargement during long-term potentiation Open
Rab-dependent membrane trafficking is critical for changing the structure and function of dendritic spines during synaptic plasticity. Here, we developed highly sensitive sensors to monitor Rab protein activity in single dendritic spines u…
View article: Greater neighborhood deprivation is related to shorter survival in behavioral‐variant frontotemporal degeneration
Greater neighborhood deprivation is related to shorter survival in behavioral‐variant frontotemporal degeneration Open
Background Emerging evidence relates neighborhood deprivation to cognitive decline and neurodegeneration but this is understudied in frontotemporal degeneration (FTD). We assessed the association of neighborhood deprivation with survival i…
View article: Ultra-Wideband Communications: Interference Challenges and Solutions
Ultra-Wideband Communications: Interference Challenges and Solutions Open
The idea of ultra-wideband (UWB) communications for short ranges (up to a few tens of meters) has been around for nearly three decades. However, despite significant efforts by the industry, UWB deployment has not yet reached its predicted …
View article: Filter-Banks for Ultra-Wideband for Communications, Sensing, and Localization
Filter-Banks for Ultra-Wideband for Communications, Sensing, and Localization Open
Recently, filter-bank multicarrier spread spectrum (FBMC-SS) has been proposed as a candidate waveform for ultra-wideband (UWB) communications, sensing, and localization. It has been noted that FBMC-SS is a perfect match to this applicatio…
View article: eLife Assessment: Epigenetic insights into GABAergic development in Dravet Syndrome iPSC and therapeutic implications
eLife Assessment: Epigenetic insights into GABAergic development in Dravet Syndrome iPSC and therapeutic implications Open
Dravet syndrome (DS) is a devastating early onset refractory epilepsy syndrome caused by variants in the SCN1A gene. A disturbed GABAergic interneuron function is implicated in the progression to DS but the underlying developmental and pat…
View article: Prolonged Activity Deprivation Causes Pre- and Postsynaptic Compensatory Plasticity at Neocortical Excitatory Synapses
Prolonged Activity Deprivation Causes Pre- and Postsynaptic Compensatory Plasticity at Neocortical Excitatory Synapses Open
Homeostatic plasticity stabilizes firing rates of neurons, but the pressure to restore low activity rates can significantly alter synaptic and cellular properties. Most previous studies of homeostatic readjustment to complete activity sile…
View article: Progressive Circuit Hyperexcitability in Mouse Neocortical Slice Cultures with Increasing Duration of Activity Silencing
Progressive Circuit Hyperexcitability in Mouse Neocortical Slice Cultures with Increasing Duration of Activity Silencing Open
Forebrain neurons deprived of activity become hyperactive when activity is restored. Rebound activity has been linked to spontaneous seizures in vivo following prolonged activity blockade. Here, we measured the time course of rebound activ…
View article: eLife Assessment: Deciphering the Genetic Code of Neuronal Type Connectivity: A Bilinear Modeling Approach
eLife Assessment: Deciphering the Genetic Code of Neuronal Type Connectivity: A Bilinear Modeling Approach Open
Understanding how different neuronal types connect and communicate is critical to interpreting brain function and behavior. However, it has remained a formidable challenge to decipher the genetic underpinnings that dictate the specific con…
View article: eLife Assessment: Temporal transcriptomic dynamics in developing macaque neocortex
eLife Assessment: Temporal transcriptomic dynamics in developing macaque neocortex Open
Despite intense research on mice, the transcriptional regulation of neocortical neurogenesis remains limited in humans and non-human primates. Cortical development in rhesus macaque is known to recapitulate multiple facets of cortical deve…
View article: eLife assessment: Deciphering the Genetic Code of Neuronal Type Connectivity: A Bilinear Modeling Approach
eLife assessment: Deciphering the Genetic Code of Neuronal Type Connectivity: A Bilinear Modeling Approach Open
Understanding how different neuronal types connect and communicate is critical to interpreting brain function and behavior. However, it has remained a formidable challenge to decipher the genetic underpinnings that dictate the specific con…
View article: Progressive circuit hyperexcitability in mouse neocortical slice cultures with increasing duration of activity silencing
Progressive circuit hyperexcitability in mouse neocortical slice cultures with increasing duration of activity silencing Open
Forebrain neurons deprived of activity become hyperactive when activity is restored. Rebound activity has been linked to spontaneous seizures in vivo following prolonged activity blockade. Here we measured the time course of rebound activi…
View article: Prolonged activity-deprivation causes pre- and postsynaptic compensatory plasticity at neocortical excitatory synapses
Prolonged activity-deprivation causes pre- and postsynaptic compensatory plasticity at neocortical excitatory synapses Open
Homeostatic plasticity stabilizes firing rates of neurons, but the pressure to restore low activity rates can significantly alter synaptic and cellular properties. Most previous studies of homeostatic readjustment to complete activity sile…
View article: Editor's evaluation: Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs
Editor's evaluation: Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Abstract Purkinje cell (PC) synapses o…
View article: Decision letter: Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells
Decision letter: Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Cortica…