Brian Panicucci
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View article: Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation
Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation Open
The long slender bloodstream form Trypanosoma brucei maintains its essential mitochondrial membrane potential (ΔΨm) through the proton-pumping activity of the F o F 1 -ATP synthase operating in the reverse mode. The ATP that drives this hy…
View article: <b>The mitochondrion from the dividing Trypanosoma brucei bloodstream form is capable of ATP production by substrate phosphorylation</b>
<b>The mitochondrion from the dividing Trypanosoma brucei bloodstream form is capable of ATP production by substrate phosphorylation</b> Open
The bloodstream form Trypanosoma brucei maintains its essential mitochondrial membrane potential (ΔΨm) through the proton-pumping activity of the FoF1-ATP synthase operating in the reverse mode. The ATP that drives this hydrolytic reaction…
View article: An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases
An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases Open
View article: Erratum for Cadena et al., “Mitochondrial Contact Site and Cristae Organization System and F <sub>1</sub> F <sub>O</sub> -ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae”
Erratum for Cadena et al., “Mitochondrial Contact Site and Cristae Organization System and F <sub>1</sub> F <sub>O</sub> -ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae” Open
View article: Method for Isolation of Myxozoan Proliferative Stages from Fish at High Yield and Purity: An Essential Prerequisite for In Vitro, In Vivo and Genomics-Based Research Developments
Method for Isolation of Myxozoan Proliferative Stages from Fish at High Yield and Purity: An Essential Prerequisite for In Vitro, In Vivo and Genomics-Based Research Developments Open
Myxozoans are a diverse group of microscopic cnidarian parasites and some representatives are associated with important diseases in fish, in both marine and freshwater aquaculture systems. Research on myxozoans has been largely hampered by…
View article: An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases
An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases Open
Mitochondrial ATP synthase forms stable dimers arranged into oligomeric assemblies that generate the inner-membrane curvature essential for efficient energy conversion. Here, we report cryo-EM structures of the intact ATP synthase dimer fr…
View article: An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases
An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases Open
Mitochondrial ATP synthase forms stable dimers arranged into oligomeric assemblies that generate the inner-membrane curvature essential for efficient energy conversion. Here, we report cryo-EM structures of the intact ATP synthase dimer fr…
View article: Mitochondrial Contact Site and Cristae Organization System and F <sub>1</sub> F <sub>O</sub> -ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae
Mitochondrial Contact Site and Cristae Organization System and F <sub>1</sub> F <sub>O</sub> -ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae Open
Mitochondria have undergone profound diversification in separate lineages that have radiated since the last common ancestor of eukaryotes some eons ago. Most eukaryotes are unicellular protists, including etiological agents of infectious d…
View article: MICOS and F<sub>1</sub>F<sub>O</sub>-ATP synthase crosstalk is a fundamental property of mitochondrial cristae
MICOS and F<sub>1</sub>F<sub>O</sub>-ATP synthase crosstalk is a fundamental property of mitochondrial cristae Open
Mitochondrial cristae are polymorphic invaginations of the inner membrane that are the fabric of cellular respiration. Both the Mitochondrial Contact Site and Cristae Organization System (MICOS) and the F O F 1 -ATP synthase are vital for …
View article: Bioenergetic consequences of FoF1–ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei
Bioenergetic consequences of FoF1–ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei Open
View article: Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei
Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei Open
Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle because the insect stage utilizes a cost-effective oxidative phosphorylation (OxPhos) to generate ATP, while bloodstream cells switch to aerobi…
View article: Inhibition of F<sub>1</sub>‐<scp>ATP</scp>ase from <i>Trypanosoma brucei</i> by its regulatory protein inhibitor Tb<scp>IF</scp><sub>1</sub>
Inhibition of F<sub>1</sub>‐<span>ATP</span>ase from <i>Trypanosoma brucei</i> by its regulatory protein inhibitor Tb<span>IF</span><sub>1</sub> Open
Hydrolysis of ATP by the mitochondrial F‐ ATP ase is inhibited by a protein called IF 1 . In the parasitic flagellate, Trypanosoma brucei , this protein, known as Tb IF 1 , is expressed exclusively in the procyclic stage, where the F‐ ATP …
View article: Cultured bloodstream Trypanosoma brucei adapt to life without mitochondrial translation release factor 1
Cultured bloodstream Trypanosoma brucei adapt to life without mitochondrial translation release factor 1 Open
Trypanosoma brucei is an extracellular parasite that alternates between an insect vector (procyclic form) and the bloodstream of a mammalian host (bloodstream form). While it was previously reported that mitochondrial release factor 1 (TbM…
View article: The F<sub>1</sub>‐<scp>ATP</scp>ase from <i>Trypanosoma brucei</i> is elaborated by three copies of an additional p18‐subunit
The F<sub>1</sub>‐<span>ATP</span>ase from <i>Trypanosoma brucei</i> is elaborated by three copies of an additional p18‐subunit Open
The F‐ ATP ases (also called the F 1 F o ‐ ATP ases or ATP synthases) are multi‐subunit membrane‐bound molecular machines that produce ATP in bacteria and in eukaryotic mitochondria and chloroplasts. The structures and enzymic mechanisms o…
View article: Trypanosoma brucei TbIF1 inhibits the essential F1-ATPase in the infectious form of the parasite
Trypanosoma brucei TbIF1 inhibits the essential F1-ATPase in the infectious form of the parasite Open
The mitochondrial (mt) FoF1-ATP synthase of the digenetic parasite, Trypanosoma brucei, generates ATP during the insect procyclic form (PF), but becomes a perpetual consumer of ATP in the mammalian bloodstream form (BF), which lacks a cano…
View article: Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei
Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei Open
Lipophilic bisphosphonium salts are among the most promising antiprotozoal leads currently under investigation. As part of their preclinical evaluation we here report on their mode of action against African trypanosomes, the etiological ag…
View article: ATPaseTb2, a Unique Membrane-bound FoF1-ATPase Component, Is Essential in Bloodstream and Dyskinetoplastic Trypanosomes
ATPaseTb2, a Unique Membrane-bound FoF1-ATPase Component, Is Essential in Bloodstream and Dyskinetoplastic Trypanosomes Open
In the infectious stage of Trypanosoma brucei, an important parasite of humans and livestock, the mitochondrial (mt) membrane potential (Δψm) is uniquely maintained by the ATP hydrolytic activity and subsequent proton pumping of the essent…
View article: The ADP/ATP Carrier and Its Relationship to Oxidative Phosphorylation in Ancestral Protist Trypanosoma brucei
The ADP/ATP Carrier and Its Relationship to Oxidative Phosphorylation in Ancestral Protist Trypanosoma brucei Open
The highly conserved ADP/ATP carrier (AAC) is a key energetic link between the mitochondrial (mt) and cytosolic compartments of all aerobic eukaryotic cells, as it exchanges the ATP generated inside the organelle for the cytosolic ADP. Try…