Brian Plotkin
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Estimating Prevalence of Human Traits Among Populations From Polygenic Risk Scores Open
The genetic basis of phenotypic variation across populations has not been well explained for most traits. Several factors may cause disparities, from variation in environments to divergent population genetic structure. We hypothesized that…
Additional file 15 of Estimating prevalence of human traits among populations from polygenic risk scores Open
Additional file 15: Table S1. Lactase persistence full data set. SNP rs number and minor allele are included, as well as the r2 values from the sensitivity analysis. The columns headed with the 1000 Genomes population codes are the allele …
Additional file 14 of Estimating prevalence of human traits among populations from polygenic risk scores Open
Additional file 14: Script used for SNP pruning method.
Differential asthma odds following respiratory infection in children from three minority populations Open
We observed population-specific associations between early-life respiratory illnesses and asthma, which were especially significant and stronger in Puerto Ricans. Taken together with the known high burden of RSV in Puerto Rico, our results…
Differential asthma risk following respiratory infection in children from three minority populations Open
Rationale Severe early-life respiratory illnesses, particularly those caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV), are strongly associated with the development of asthma in children. Puerto Rican children in part…