Brian R. Boettcher
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View article: Cevoglitazar, a Novel Peroxisome Proliferator-Activated Receptor-α/γ Dual Agonist, Potently Reduces Food Intake and Body Weight in Obese Mice and Cynomolgus Monkeys
Cevoglitazar, a Novel Peroxisome Proliferator-Activated Receptor-α/γ Dual Agonist, Potently Reduces Food Intake and Body Weight in Obese Mice and Cynomolgus Monkeys Open
Cevoglitazar is a dual agonist for the peroxisome proliferator-activated receptor (PPAR)-α and -γ subtypes. Dual activation of PPARα and -γ is a therapeutic approach in development for the treatment of type 2 diabetes mellitus and diabetic…
View article: The mechanisms underlying the unique pharmacodynamics of nateglinide
The mechanisms underlying the unique pharmacodynamics of nateglinide Open
View article: Phenotypic Correction of Diabetic Mice by Adenovirus-Mediated Glucokinase Expression
Phenotypic Correction of Diabetic Mice by Adenovirus-Mediated Glucokinase Expression Open
Hyperglycemia of diabetes is caused in part by perturbation of hepatic glucose metabolism. Hepatic glucokinase (GK) is an important regulator of glucose storage and disposal in the liver. GK levels are lowered in patients with maturity-ons…
View article: Treatment of Type 2 Diabetes by Adenoviral-Mediated Overexpression of the Glucokinase Regulatory Protein
Treatment of Type 2 Diabetes by Adenoviral-Mediated Overexpression of the Glucokinase Regulatory Protein Open
The enzyme glucokinase (GK) plays a central role in glucose homeostasis. Hepatic GK activity is acutely controlled by the action of the GK regulatory protein (GKRP). In vitro evidence suggests that GKRP reversibly binds to GK and inhibits …
View article: Cloning, expression, and characterization of human apolipoprotein(a) kringle IV37.
Cloning, expression, and characterization of human apolipoprotein(a) kringle IV37. Open
A portion of kringle IV37 (KIV37) of apolipoprotein (a), (apo(a)), was polymerase chain reaction-cloned from human liver cDNA. The protein product of this clone was expressed in Escherichia coli as a poly histidine fusion protein. Based on…
View article: Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase.
Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase. Open
Rat hepatic microsomal squalene synthetase (EC 2.5.1.21) was induced 25-fold by feeding rats with diet containing the hydroxymethylglutaryl-coenzyme A reductase inhibitor, fluvastatin, and cholestyramine, a bile acid sequestrant. A soluble…
View article: Regulation of Escherichia coli carbamyl phosphate synthetase. Evidence for overlap of the allosteric nucleotide binding sites.
Regulation of Escherichia coli carbamyl phosphate synthetase. Evidence for overlap of the allosteric nucleotide binding sites. Open
Regulation of Escherichia coli carbamyl phosphate synthetase by UMP and IMP was examined in studies with various analogs of these nucleotides. Whereas UMP inhibits enzyme activity, the arabinose analog of UMP was found to be an activator. …
View article: Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis.
Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis. Open
Depletion of glutathione by inhibition of its synthesis by buthionine sulfoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, leads to increased sensitivity to (i) irradiation and (ii) oxidative stress. In the present …
View article: Conversion of UMP, an allosteric inhibitor of carbamyl phosphate synthetase, to an activator by modification of the UMP ribose moiety.
Conversion of UMP, an allosteric inhibitor of carbamyl phosphate synthetase, to an activator by modification of the UMP ribose moiety. Open
UMP is known to be an allosteric inhibitor of carbamyl phosphate synthetase, whereas IMP activates the enzyme. Surprisingly, dialdehyde UMP (prepared by periodate oxidation of UMP) was found to be a potent activator of the enzyme. Dialdehy…
View article: Covalent modification of the active site of carbamyl phosphate synthetase by 5'-p-fluorosulfonylbenzoyladenosine. Direct evidence for two functionally different ATP-binding sites.
Covalent modification of the active site of carbamyl phosphate synthetase by 5'-p-fluorosulfonylbenzoyladenosine. Direct evidence for two functionally different ATP-binding sites. Open
View article: Isolation of human lactate dehydrogenase isoenzyme X by affinity chromatography
Isolation of human lactate dehydrogenase isoenzyme X by affinity chromatography Open
Human isoenzyme LDH-X (lactate dehydrogenase isoenzyme X) was isolated from seminal fluid of frozen semen samples by affinity chromatography by using oxamate-Sepharose and AMP-Sepharose. In the presence of 1.6 mM-NAD+, isoenzyme LDH-X does…
View article: Oxygen Binding of Monotrene Haemoglobins II. Fixation of Functionally Non-equivalent Haemoglobins in the Echidna Population
Oxygen Binding of Monotrene Haemoglobins II. Fixation of Functionally Non-equivalent Haemoglobins in the Echidna Population Open
The echidna, Tachyglossus aculeatus, has two haemoglobins and polymorphic variants of both have been described. Haemoglobins Hb-IA, Hb-IB and Hb-IIA have been separated and their oxygen binding parameters studied. Hb-IIA has a markedly hig…
View article: Magnetic resonance relaxation rates in the study of complexes of ligands with spin-labeled aspartate transaminase
Magnetic resonance relaxation rates in the study of complexes of ligands with spin-labeled aspartate transaminase Open
View article: Fluorine-19 as a covalent active site-directed magnetic resonance probe in aspartate transaminase.
Fluorine-19 as a covalent active site-directed magnetic resonance probe in aspartate transaminase. Open
copyright UK Data Service and data collection copyright owner.These data were collected as part of a research project run by Dr Leigh Shaw-Taylor and Professor E.A. Wrigley and funded by the Economic and Social Research Council: Male occup…