Brian R. Raux
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View article: Current Evidence and Gaps for Outpatient Respiratory Tract Infection Diagnostics: A Call to Action
Current Evidence and Gaps for Outpatient Respiratory Tract Infection Diagnostics: A Call to Action Open
Antimicrobial stewardship programs (ASPs) are underrepresented in outpatient settings, where antibiotic use and overprescribing are common. Upper respiratory tract infections (URIs) account for 30% of outpatient antibiotic prescriptions, h…
View article: Real-World Applications of Imipenem-Cilastatin-Relebactam: Insights From a Multicenter Observational Cohort Study
Real-World Applications of Imipenem-Cilastatin-Relebactam: Insights From a Multicenter Observational Cohort Study Open
Background Multidrug-resistant (MDR) gram-negative infections are a substantial threat to patients and public health. Imipenem-cilastatin-relebactam (IMI/REL) is a β-lactam/β-lactamase inhibitor with expanded activity against MDR Pseudomon…
View article: P-1500. Evaluation of Imipenem-cilastatin-relebactam for the Treatment of Infections Caused by <i>Pseudomonas aeruginosa</i>
P-1500. Evaluation of Imipenem-cilastatin-relebactam for the Treatment of Infections Caused by <i>Pseudomonas aeruginosa</i> Open
Background The escalating prevalence of multidrug-resistant (MDR) Pseudomonas aeruginosa presents a serious threat to patient care due to its limited treatment options. However, imipenem-cilastatin-relebactam (IMI/REL) is a promising beta-…
View article: Navigating the network: a narrative overview of AMR surveillance and data flow in the United States
Navigating the network: a narrative overview of AMR surveillance and data flow in the United States Open
The antimicrobial resistance (AMR) surveillance landscape in the United States consists of a data flow that starts in the clinical setting and is maintained by a network of national and state public health laboratories. These organizations…
View article: Risk factors for predicting extended-spectrum β-lactamase-producing Enterobacterales (ESBLE) infections in non-urinary isolates
Risk factors for predicting extended-spectrum β-lactamase-producing Enterobacterales (ESBLE) infections in non-urinary isolates Open
Background: With increases in antimicrobial resistance, it is crucial that patients receive appropriate antimicrobial therapy in a timely manner. Advancements in rapid diagnostics offer the ability to identify resistant organisms quickly. …
View article: Evaluation of the impact of nasal colonization with methicillin-resistant <i>Staphylococcus aureus</i> on left ventricular assist device infections
Evaluation of the impact of nasal colonization with methicillin-resistant <i>Staphylococcus aureus</i> on left ventricular assist device infections Open
In this retrospective cohort study, we evaluated the predictive value of methicillin-resistant Staphylococcus aureus (MRSA) nasal swabs for the development of MRSA infections in patients with left ventricular assist devices. In 106 patient…
View article: Opportunities for antibiotic stewardship in emergency department or hospitalized patients with asymptomatic bacteriuria: identifying risk factors for antibiotic treatment
Opportunities for antibiotic stewardship in emergency department or hospitalized patients with asymptomatic bacteriuria: identifying risk factors for antibiotic treatment Open
Antibiotic treatment of asymptomatic bacteriuria (ASB) is considered inappropriate and may lead to adverse events. This 2-center, retrospective cohort study including emergency department or inpatient adults identified pyuria (odds ratio, …
View article: Association between duration of antipseudomonal beta-lactam therapy and <i>Clostridioides difficile</i> infections in monomicrobial <i>Enterobacterales</i> bloodstream infections at an academic medical center
Association between duration of antipseudomonal beta-lactam therapy and <i>Clostridioides difficile</i> infections in monomicrobial <i>Enterobacterales</i> bloodstream infections at an academic medical center Open
Objective: To evaluate the effects early de-escalation of antipseudomonal β-lactam (APBL) on 90-day CDI risk in Enterobacterales bloodstream infections (BSIs). Design: Retrospective cohort analysis. Setting: An academic medical center in S…
View article: Early Multicenter Experience With Imipenem-Cilastatin-Relebactam for Multidrug-Resistant Gram-Negative Infections
Early Multicenter Experience With Imipenem-Cilastatin-Relebactam for Multidrug-Resistant Gram-Negative Infections Open
A multicenter case series of 21 patients were treated with imipenem-cilastatin-relebactam. There were mixed infection sources, with pulmonary infections (11/21,52%) composing the majority. The primary pathogen was Pseudomonas aeruginosa (1…
View article: 219. Characteristics Associated with Inappropriate Antibiotic Prescribing in Patients with Asymptomatic Bacteriuria (ASB)
219. Characteristics Associated with Inappropriate Antibiotic Prescribing in Patients with Asymptomatic Bacteriuria (ASB) Open
Background Antibiotic treatment of asymptomatic bacteriuria (ASB) is considered inappropriate, does not improve patient outcomes, and may lead to adverse events such as antibiotic resistance and Clostridioides difficile infection. Previous…
View article: 1065. Keeping Score: Utilizing a Prioritization Tool to Create Multidisciplinary Antimicrobial Stewardship Documentation
1065. Keeping Score: Utilizing a Prioritization Tool to Create Multidisciplinary Antimicrobial Stewardship Documentation Open
Background A multidisciplinary approach using pre-authorization and/or prospective audit and feedback combined with institutional guidelines, personnel education, and intervention monitoring is essential for successful antimicrobial stewar…
View article: 1438. Escherichia coli (EC) ST131-H30 Clonal Group is Associated with Antimicrobial Resistance, Illness Severity, Host Compromise, and Non-Cure among Patients with Bacteriuria
1438. Escherichia coli (EC) ST131-H30 Clonal Group is Associated with Antimicrobial Resistance, Illness Severity, Host Compromise, and Non-Cure among Patients with Bacteriuria Open
Background EC sequence type ST131 is the leading cause of extraintestinal EC infections, and accounts for most fluoroquinolone (FQ)-resistant and extended-spectrum β-lactamase (ESBL)-producing EC clinical isolates. The ST131-H30 subclone (…
View article: 1883. Acute Kidney Injury in Patients With Pneumonia on Concomitant Anti-Methicillin-Resistant <i>Staphylococcus aureus</i> and Anti-Pseudomonal β-Lactam Therapy
1883. Acute Kidney Injury in Patients With Pneumonia on Concomitant Anti-Methicillin-Resistant <i>Staphylococcus aureus</i> and Anti-Pseudomonal β-Lactam Therapy Open
BACKGROUND: Empiric antibiotic treatment of serious and healthcare-associated pneumonia (PNA) often includes coverage of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PSA). Recent publications suggest that …
View article: Contents Vol. 62, 2017
Contents Vol. 62, 2017 Open
and/or infrequently employed drug.
View article: Utilization of FilmArray Gastrointestinal Panel (GIP) Results on Altering Empiric Antibiotic (ABX) Use in Patients with Acute Diarrhea
Utilization of FilmArray Gastrointestinal Panel (GIP) Results on Altering Empiric Antibiotic (ABX) Use in Patients with Acute Diarrhea Open
Acute infectious diarrhea is a leading cause of hospitalizations, outpatient visits, and lost quality of life in the United States. Rapid diagnostic technology may provide an opportunity to quickly optimize ABX therapy for acute infectious…
View article: Susceptibility of Multidrug-Resistant Gram-Negative Urine Isolates to Oral Antibiotics
Susceptibility of Multidrug-Resistant Gram-Negative Urine Isolates to Oral Antibiotics Open
Increasing resistance among Gram-negative uropathogens limits treatment options, and susceptibility data for multidrug-resistant isolates are limited. We assessed the activity of five oral agents against 91 multidrug-resistant Gram-negativ…
View article: Appropriateness of Treatment of Gram-Negative Bacteriuria in a Large Academic Hospital
Appropriateness of Treatment of Gram-Negative Bacteriuria in a Large Academic Hospital Open