Brian Rayner
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View article: NOS3 rs3918188C>A is associated with susceptibility to resistant hypertension while CES1 genetic variation was not associated with resistant hypertension among South Africans
NOS3 rs3918188C>A is associated with susceptibility to resistant hypertension while CES1 genetic variation was not associated with resistant hypertension among South Africans Open
Introduction Genetic variation in genes coding for enzymes metabolising antihypertensive drugs, may affect the efficacy of angiotensin converting enzyme (ACE) inhibitors such as enalapril, potentially leading to resistant hypertension (RHT…
View article: Cardiometabolic protein expression levels and pathways associated with kidney function decline in older European adults with advanced kidney disease
Cardiometabolic protein expression levels and pathways associated with kidney function decline in older European adults with advanced kidney disease Open
Background Cardiovascular disease and chronic kidney disease (CKD) progression pathophysiology are similar. We investigated associations of cardiometabolic protein expression and pathways with kidney function decline in older adults with a…
View article: Efficacy and safety of daprodustat in patients on peritoneal dialysis in the ASCEND-D trial
Efficacy and safety of daprodustat in patients on peritoneal dialysis in the ASCEND-D trial Open
Background and hypothesis Daprodustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, is approved for treatment of anemia in dialysis patients with CKD in some parts of the world. This subgroup analysis examined the efficac…
View article: Consistency of alerts generated by, and implementation of, the NHS England acute kidney injury detection algorithm in English laboratories
Consistency of alerts generated by, and implementation of, the NHS England acute kidney injury detection algorithm in English laboratories Open
Background National Health Services (NHS) England mandates that an acute kidney injury (AKI) detection algorithm be embedded in laboratories. We evaluated the implementation of the algorithm and the consistency of alerts submitted to the U…
View article: Genetic Variation in ABCB1, ADRB1, CYP3A4, CYP3A5, NEDD4L and NR3C2 Confers Differential Susceptibility to Resistant Hypertension among South Africans
Genetic Variation in ABCB1, ADRB1, CYP3A4, CYP3A5, NEDD4L and NR3C2 Confers Differential Susceptibility to Resistant Hypertension among South Africans Open
Resistant hypertension (RHTN) prevalence ranges from 4 to 19% in Africa. There is a paucity of data on the role of genetic variation on RHTN among Africans. We set out to investigate the role of polymorphisms in ABCB1, ADRB1, CYP3A4, CYP3A…
View article: WCN24-736 INCIDENCE AND CHARACTERISTICS OF HEALTHCARE CLIENTS WITH ACUTE-ON-CHRONIC KIDNEY DISEASE IN THE CITY OF CAPE TOWN, SOUTH AFRICA
WCN24-736 INCIDENCE AND CHARACTERISTICS OF HEALTHCARE CLIENTS WITH ACUTE-ON-CHRONIC KIDNEY DISEASE IN THE CITY OF CAPE TOWN, SOUTH AFRICA Open
Acute kidney injury (AKI) in people with chronic kidney disease (CKD) is an important driver of CKD progression and is associated with higher mortality and the need for kidney replacement therapy initiation. We investigated the incidence a…
View article: Genetic Factors Contributing to the Pathogenesis of Essential Hypertension in Two African Populations
Genetic Factors Contributing to the Pathogenesis of Essential Hypertension in Two African Populations Open
The African continent has the highest prevalence of hypertension globally, with South Africa reporting the highest prevalence in Southern Africa. While the influence of genetic variability in the pathogenesis of hypertension is well descri…
View article: Genetic Factors Contributing to the Pathogenesis of Essential Hypertension in Two African Populations
Genetic Factors Contributing to the Pathogenesis of Essential Hypertension in Two African Populations Open
The African continent has the highest prevalence of hypertension globally, with South Africa reporting the highest prevalence in Southern Africa. While the influence of genetic variability in the pathogenesis of hypertension is well descri…
View article: Cardiorenal effects of SGLT2 inhibitors: who might benefit?
Cardiorenal effects of SGLT2 inhibitors: who might benefit? Open
Sodium glucose co-transporter-2 inhibitors have been shown to have multiple cardiovascular and renal benefits in patients with type 2 diabetes. In large randomised controlled trials they reduced major cardiovascular outcomes, hospitalisati…
View article: Major Genetic Drivers of Statin Treatment Response in African Populations and Pharmacogenetics of Dyslipidemia Through a One Health Lens
Major Genetic Drivers of Statin Treatment Response in African Populations and Pharmacogenetics of Dyslipidemia Through a One Health Lens Open
A One Health lens is increasingly significant to address the intertwined challenges in planetary health concerned with the health of humans, nonhuman animals, plants, and ecosystems. A One Health approach can benefit the public health syst…
View article: Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases Open
Pharmacogenomics may improve patient care by guiding drug selection and dosing; however, this requires prior knowledge of the pharmacogenomics of drugs commonly used in a specific setting. The aim of this study was to identify a preliminar…
View article: Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases Open
Pharmacogenomics may improve patient care by guiding drug selection and dosing, however this requires prior knowledge of the pharmacogenomics of drugs commonly used in a specific setting. The aim of this study was to identify a preliminary…
View article: #2697 ASSOCIATION OF CARDIOMETABOLIC PROTEINS WITH EGFR DECLINE IN OLDER ADULTS WITH ADVANCED CHRONIC KIDNEY DISEASE
#2697 ASSOCIATION OF CARDIOMETABOLIC PROTEINS WITH EGFR DECLINE IN OLDER ADULTS WITH ADVANCED CHRONIC KIDNEY DISEASE Open
Background and Aims Cardiovascular disease and advanced chronic kidney disease often coexist and share risk factors in older individuals. We investigated the association of cardiometabolic and cardiovascular proteins and pathways with decl…
View article: Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans
Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans Open
In Africa, the burden of hypertension has been rising at an alarming rate for the last two decades and is a major cause for cardiovascular disease (CVD) mortality and morbidity. Hypertension is characterised by elevated blood pressure (BP)…
View article: Advances in Chronic Kidney Disease in Africa
Advances in Chronic Kidney Disease in Africa Open
Africa, particularly sub-Sharan Africa (SSA), faces major challenges in respect to chronic kidney disease (CKD). There is a rising prevalence due to the combined effects of hypertension, diabetes, and human immunodeficiency virus (HIV) (an…
View article: The Evolving Spectrum of Kidney Histology in HIV-Positive Patients in South Africa
The Evolving Spectrum of Kidney Histology in HIV-Positive Patients in South Africa Open
As ART programs intensified and increasingly used TDF, the spectrum of kidney histology in PWH evolved from a predominance of HIVAN in the early ART era to TID in recent times. The increase in TID is likely due to multiple exposures that i…
View article: Primary Sjögren’s syndrome with renal tubular acidosis and central pontine myelinolysis: An unusual triad
Primary Sjögren’s syndrome with renal tubular acidosis and central pontine myelinolysis: An unusual triad Open
Primary Sjögren's syndrome (pSS) is a complex, multisystem autoimmune disorder. It is characterized by lymphocytic infiltration of the exocrine glands. In the setting of pSS, the presence of systemic disease is an important prognostic dete…
View article: Disseminated Mycobacterium Tuberculosis and IgA Nephropathy
Disseminated Mycobacterium Tuberculosis and IgA Nephropathy Open
Mycobacterium tuberculosis (MTB) is an under-recognised cause of genitourinary disease. IgA nephropathy (IgAN), a leading cause of glomerulonephritis worldwide, has been described as a rare consequence of disseminated MTB infection. In thi…
View article: Effect of 3, 2-Drug Combinations of Antihypertensive Therapies on Blood Pressure Variability in Black African Patients: Secondary Analyses of the CREOLE Trial
Effect of 3, 2-Drug Combinations of Antihypertensive Therapies on Blood Pressure Variability in Black African Patients: Secondary Analyses of the CREOLE Trial Open
Background: The effect of 3 commonly recommended combinations of anti-hypertensive agents—amlodipine plus hydrochlorothiazide (calcium channel blocker [CCB]+thiazide), amlodipine plus perindopril (CCB+ACE [angiotensin-converting enzyme]-in…
View article: Prophylaxis is the new standard of care in patients with haemophilia
Prophylaxis is the new standard of care in patients with haemophilia Open
Randomised controlled clinical trial evidence on prophylaxis as optimal care for patients with haemophilia was generated more than a decade ago. However, this knowledge has not translated into clinical practice in South Africa (SA) owing t…
View article: Challenges of Conducting Clinical Trials during the SARS-CoV-2 Pandemic: The ASCEND Global Program Experience
Challenges of Conducting Clinical Trials during the SARS-CoV-2 Pandemic: The ASCEND Global Program Experience Open
The coronavirus disease 2019 pandemic has had an unprecedented effect on health and health care and posed challenges to the conduct of clinical trials.Targeted mitigating strategies, on the basis of early and continued data collection from…
View article: A Differential Response to Antihypertensive Therapy in African Men and Women: Insights From the CREOLE Trial
A Differential Response to Antihypertensive Therapy in African Men and Women: Insights From the CREOLE Trial Open
Background We sought to address the paucity of data to support the evidence-based management of hypertension to achieve optimal blood pressure (BP) control on a sex-specific basis in Africa. Methods We undertook a post hoc analysis of the …
View article: Hypertension in the South African public healthcare system: a cost-of-illness and burden of disease study
Hypertension in the South African public healthcare system: a cost-of-illness and burden of disease study Open
Objectives To quantify the health and economic burden of hypertension in the South African public healthcare system. Setting All inpatient, outpatient and rehabilitative care received in the national public healthcare system. Participants …
View article: COVID-19 complications in a small-town hospital in South Africa
COVID-19 complications in a small-town hospital in South Africa Open
South Africa has experienced three deadly waves of the COVID-19 pandemic with devastating consequences, but little is known about the experiences in small-town hospitals in the country. Between May 2020 and June 2021, author GC treated ~10…
View article: PASCAR commentary on the International Society of Hypertension global guidelines 2020: relevance to sub-Saharan Africa
PASCAR commentary on the International Society of Hypertension global guidelines 2020: relevance to sub-Saharan Africa Open
Hypertension guidelines have been based on country-specific data until the publication of the International Society of Hypertension (ISH) global guidelines. The major differences between the ISH global guidelines and other international gu…
View article: A multicentre cross-sectional descriptive study evaluating the cardiovascular risk profile of preoperatively identified patients with hypertension
A multicentre cross-sectional descriptive study evaluating the cardiovascular risk profile of preoperatively identified patients with hypertension Open
The perioperative period is a critical time during which surgeons, nurses and anaesthetists can influence patients' CV risk of adverse events. This involves appropriate screening, education and treatment. In this study population, nearly 9…