Brian Shariffi
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View article: Habitual sleep duration is associated with heightened muscle sympathetic nerve activation and blood pressure reactivity in response to the cold pressor test
Habitual sleep duration is associated with heightened muscle sympathetic nerve activation and blood pressure reactivity in response to the cold pressor test Open
Recent evidence has suggested that habitual sleep duration is not strongly associated with resting sympathetic neural activity. However, the present findings suggest that habitual sleep duration is inversely associated with muscle sympathe…
View article: Resveratrol restores indices of neurovascular coupling following acute sleep restriction in young men and women
Resveratrol restores indices of neurovascular coupling following acute sleep restriction in young men and women Open
Herein, we demonstrate that one night of restricted sleep (4 h time in bed) impairs the link between neural activity and cerebral blood flow (i.e., neurovascular coupling, NVC) of both middle and posterior cerebral arteries, and oral resve…
View article: Role of overweight and obesity on vascular responses to the cold pressor test and hypoxia in women
Role of overweight and obesity on vascular responses to the cold pressor test and hypoxia in women Open
Sympathetic-mediated vasoconstriction is attenuated during hypoxia in young women with normal weight, demonstrating the expected hypoxic sympatholysis. Conversely, hypoxic sympatholysis is attenuated in women with increased adiposity, desp…
View article: β-Adrenergic receptors mediate sex differences in vasodilation but not sympathetic-mediated vasoconstriction during hypoxia
β-Adrenergic receptors mediate sex differences in vasodilation but not sympathetic-mediated vasoconstriction during hypoxia Open
β-Adrenergic receptors contribute to hypoxic vasodilation, attenuate sympathetic vasoconstriction at rest, and are more sensitive in females versus males. We hypothesized β-adrenergic receptor blockade would blunt hypoxic vasodilation and …
View article: Impact of acute sleep restriction on cerebrovascular reactivity and neurovascular coupling in young men and women
Impact of acute sleep restriction on cerebrovascular reactivity and neurovascular coupling in young men and women Open
Chronic exposure to shortened sleep is associated with an increased risk of Alzheimer’s disease and dementia. We examined the effect of acute sleep restriction (4-h time in bed) on cerebral blood flow in response to a metabolic (carbon dio…
View article: Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults
Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults Open
Insulin has important vasodilatory effects in the peripheral circulation, but less is known about the role of insulin in cerebrovascular control. Contrary to our hypothesis, there was no effect of systemic (intravenous) nor local (intranas…
View article: Effect of acute intranasal insulin administration on muscle sympathetic nerve activity in healthy young adults
Effect of acute intranasal insulin administration on muscle sympathetic nerve activity in healthy young adults Open
Systemic insulin increases muscle sympathetic nerve activity (MSNA) via central actions within the brainstem and peripheral activation of the arterial baroreflex. In the absence of peripheral insulin action, whether central insulin stimula…
View article: Reproducibility and diurnal variation in middle cerebral artery blood velocity in healthy humans
Reproducibility and diurnal variation in middle cerebral artery blood velocity in healthy humans Open
Transcranial Doppler (TCD) is used to assess cerebral blood velocity (CBV) and cerebrovascular reactivity (CVR). Assessments of TCD reproducibility are limited, and few include multiple within‐day measurements. We sought to establish repro…
View article: Role of the arterial baroreflex in the sympathetic response to hyperinsulinemia in adult humans
Role of the arterial baroreflex in the sympathetic response to hyperinsulinemia in adult humans Open
We hypothesized that elevation in muscle sympathetic nervous system activity (MSNA) during hyperinsulinemia is mediated by its peripheral vasodilator effect on the arterial baroreflex. Using three separate protocols in humans, we observed …
View article: Maybe angiotensin II is getting on our nerves, and the role of exercise
Maybe angiotensin II is getting on our nerves, and the role of exercise Open
The coronavirus disease (COVID-19) is caused by the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its emergence in 2019 has elicited an ongoing pandemic, affecting millions of individuals worldwide. Internalization of…
View article: Hyperinsulinemia blunts sympathetic vasoconstriction: a possible role of β-adrenergic activation
Hyperinsulinemia blunts sympathetic vasoconstriction: a possible role of β-adrenergic activation Open
Herein we report in a sample of healthy young men ( n = 14) and women ( n = 12) that hyperinsulinemia induces time-dependent decreases in total peripheral resistance and its contribution to the maintenance of blood pressure. In the same pa…
View article: Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Normal Body Weight and Obese Males
Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Normal Body Weight and Obese Males Open
Recently, it has been reported that dietary supplementation with grape seed extract (GSE) ameliorates endothelial function and increase nitric oxide (NO) bioavailability. Thus, we investigated if elevated blood pressure and aortic stiffnes…