Brian Sweeney
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View article: Cognitive outcomes and performance of patients diagnosed and treated for N-Methyl-D-Aspartate receptor antibody-mediated (NMDAR) encephalitis compared with patients with schizophrenia and healthy controls
Cognitive outcomes and performance of patients diagnosed and treated for N-Methyl-D-Aspartate receptor antibody-mediated (NMDAR) encephalitis compared with patients with schizophrenia and healthy controls Open
Study findings suggest cognitive performance in patients treated for NMDAR encephalitis approaches normal over time. Prompt treatment with immunotherapy is associated with improved cognitive outcomes. Psychiatric services should be aware o…
View article: Mapping Emergency Medicine Data to the Observational Medical Outcomes Partnership Common Data Model: A Gap Analysis of the American College of Emergency Physicians Clinical Emergency Data Registry
Mapping Emergency Medicine Data to the Observational Medical Outcomes Partnership Common Data Model: A Gap Analysis of the American College of Emergency Physicians Clinical Emergency Data Registry Open
The OMOP-CDM presents a promising framework for standardizing emergency medicine data, thereby enhancing future query automation, analytics, and cross-institutional collaboration. Despite the potential challenges in capturing unique CEDR f…
View article: AB023. SOH24AB_276. Negative appendectomy rates (NAR) in paediatric pubertal females—is there room for improvement?
AB023. SOH24AB_276. Negative appendectomy rates (NAR) in paediatric pubertal females—is there room for improvement? Open
Background: Negative appendectomy is a diagnostic error and exposes patients to potential surgical complications. Negative appendectomy rate (NAR) varies widely (15–39%). Paediatric females of child bearing age (CBA) have a higher NAR (as …
View article: Germline mosaicism in a family with<i>MBD5</i>haploinsufficiency
Germline mosaicism in a family with<i>MBD5</i>haploinsufficiency Open
Haploinsufficiency of the methyl-CpG-binding domain protein 5 ( MBD5 ) gene causes a neurodevelopmental disorder that includes intellectual disability, developmental delay, speech impairment, seizures, sleep disturbances, and behavioral di…
View article: AB077. SOH22ABS122. A review of appendicitis-related acute referrals to Children’s Health Ireland from non-specialist paediatric surgical centres
AB077. SOH22ABS122. A review of appendicitis-related acute referrals to Children’s Health Ireland from non-specialist paediatric surgical centres Open
Background: Acute appendicitis is the commonest surgical emergency in children. Eighty percent of the 3,197 paediatric appendicectomies are performed in Ireland annually are performed by adult general surgeons; the remaining 20% are perfor…
View article: Asymptomatic idiopathic intracranial hypertension post female to male gender transition
Asymptomatic idiopathic intracranial hypertension post female to male gender transition Open
A 23- year-man post female to male (FTM) gender transition was found to have bilateral papilloedema at a routine optician visit. The patient was referred on for formal ophthalmological and neurological assessments. Optical coherence tomogr…
View article: Vocal cord paralysis as a presenting sign of autosomal recessive spinocerebellar atrophy type 10
Vocal cord paralysis as a presenting sign of autosomal recessive spinocerebellar atrophy type 10 Open
Acquired vocal cord paralysis (VCP) is caused by dysfunction or injury of one or both recurrent laryngeal nerves. Here we report a 41-year-old man with spinocerebellar atrophy, autosomal recessive type 10 (SCAR10) due to an autosomal reces…
View article: Change in urban and non-urban pattern of ED use during the COVID-19 pandemic in 28 Michigan hospitals: an observational study
Change in urban and non-urban pattern of ED use during the COVID-19 pandemic in 28 Michigan hospitals: an observational study Open
Objective To assess the trends in visits, overall and by age, to urban and non-urban emergency departments (EDs), and visits resulting in admission to hospital before and during the COVID-19 pandemic using a large regional database. Settin…
View article: The future of genomics in Ireland – focus on genomics for health
The future of genomics in Ireland – focus on genomics for health Open
Genomics is revolutionizing biomedical research, medicine and healthcare globally in academic, public and industry sectors alike. Concrete examples around the world show that huge benefits for patients, society and economy can be accrued t…
View article: ‘Should have gone to …’: bilateral papilloedema with normal CSF pressure due to vestibular schwannoma
‘Should have gone to …’: bilateral papilloedema with normal CSF pressure due to vestibular schwannoma Open
A 24-year-old woman presented with bilateral blurring of her distance vision and ‘dizzy spells’. She had no other neurological symptoms or medical history. She consulted an optometrist, and optical coherence tomography (OCT) was performed,…
View article: Late‐Onset Tay‐Sachs Disease in an Irish Family
Late‐Onset Tay‐Sachs Disease in an Irish Family Open
Background Late‐onset Tay‐Sachs disease (LOTS) is an autosomal‐recessive lysosomal storage disease caused by deficient β‐hexosaminidase A activity. LOTS is rare in the Ashkenazi Jews, but even rarer in the non‐Jewish population. Cases We r…
View article: A Rare Presentation of Paraneoplastic Striatal Encephalitis Associated with Nonsmall Cell Lung Cancer
A Rare Presentation of Paraneoplastic Striatal Encephalitis Associated with Nonsmall Cell Lung Cancer Open
Paraneoplastic striatal encephalitis (PSE) is relatively unusual, accounting for only 1% of all paraneoplastic neurological syndromes.1 PSE is usually found in association with the presence of onconeural anti-CV2/collapsin response mediato…
View article: 196 A Structured Literature Review of Diagnostic Processes and Pathways for People Living with Younger Onset Dementia
196 A Structured Literature Review of Diagnostic Processes and Pathways for People Living with Younger Onset Dementia Open
Background Currently, 1 in 10 people diagnosed with dementia in Ireland are aged under 65, this is termed “Younger Onset Dementia” (YOD). Though small in numbers these figures (4000 people) are increasing, and important differences exist b…
View article: P636 An unusual cause of gluteal swelling.....congenital rectal duplication cyst
P636 An unusual cause of gluteal swelling.....congenital rectal duplication cyst Open
Rectal Duplication (RD) is a very rare phenomenon with only around 100 cases reported.They make up a merely 5% of all intestinal duplication's. Most of the rectal duplication's are located in the retro rectal space. Presenting symptoms inc…
View article: Teaching Video Neuro <i>Images</i> : Primary writing tremor
Teaching Video Neuro <i>Images</i> : Primary writing tremor Open
A 30-year-old woman with recurring optic neuritis presented with tremor affecting her right hand when writing only (video at [Neurology.org][1]). An MRI brain (figure) revealed lesions in the left midbrain, right middle cerebellar peduncle…
View article: Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology
Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology Open
Multiple Sclerosis (MS), an idiopathic progressive immune-mediated neurological disorder of the central nervous system (CNS), is characterized by recurrent episodes of inflammatory demyelination and consequent axonal deterioration. It acco…